Separating poroviscoelastic deformation mechanisms in hydrogels

Strange, Daniel G. T.; Fletcher, Timothy L.; Tonsomboon, Khaow; Brawn, Helen; Zhao, Xuanhe; Oyen, Michelle L.

doi:10.1063/1.4789368

Cited by 87 publications

(62 citation statements)

References 23 publications

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“…The fitting parameters, B k , identified by eqn (13) can be converted to material parameters, C k , as described elsewhere, 14 however this requires the assumption that the load-relaxation is primarily viscoelastic in nature. For gels with concurrent viscoelastic and poroelastic dynamics, convenient conversion to material properties is not well defined as the overall load-relaxation behavior is the product of the viscoelastic and poroelastic responses 17 . Because of this, logarithmic contour plots for varying characteristic loads, R 2 M , were generated using eqn (11) and b 1 = 0.7, and the experimental data overlaid in order to provide bounds on the indention modulus (Fig.…”

Section: Resultsmentioning

confidence: 99%

Mechanical measurements of heterogeneity and length scale effects in PEG-based hydrogels

et al. 2015

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Colloidal-probe spherical indentation load-relaxation experiments with a probe radius of 3 μm are conducted on poly(ethylene glycol) (PEG) hydrogel materials to quantify their steady-state mechanical properties and time-dependent transport properties via a single experiment. PEG-based hydrogels are shown to be heterogeneous in both morphology and mechanical stiffness at this scale; a linear-harmonic interpolation of hyperelastic Mooney-Rivlin and Boussinesq flat-punch indentation models was used to describe the steady-state response of the hydrogels and determine upper and lower bounds for indentation moduli. Analysis of the transient load-relaxation response during displacement-controlled hold periods provides a means of extracting two time constants τ1 and τ2, where τ1 and τ2 are assigned to the viscoelastic and poroelastic properties, respectively. Large τ2 values at small indentation depths provide evidence of a non-equilibrium state characterized by a phenomenon that restricts poroelastic fluid flow through the material; for larger indentations, the variability in τ2 values decreases and pore sizes estimated from τ2 via indentation approach those measured via macroscopic swelling experiments. The contact probe methodology developed here provides a means of assessing hydrogel heterogeneity, including time-dependent mechanical and transport properties, and has potential implications in hydrogel biomedical and engineering applications.

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Section: Resultsmentioning

confidence: 99%

Mechanical measurements of heterogeneity and length scale effects in PEG-based hydrogels

et al. 2015

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“…3). Inset shows the way λ ο was calculated demarcating the transition from Rouse modes to power law relaxation samples) and contributes to the terminal relaxation processes (Oyen 2013;Strange et al 2013;Wang et al 2014). Poroviscoelastic relaxation analysis has not received attention for gluten networks although some work is available in the literature for other biopolymer systems, as for instance for gelatin (Forte et al 2015;Galli et al 2011;Kalyanam et al 2009), alginate (Cai et al 2010), or fibrin gels (Noailly et al 2008).…”

Section: Continuous Relaxation Spectramentioning

confidence: 99%

Influence of supramolecular forces on the linear viscoelasticity of gluten

2016

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Stress relaxation behavior of hydrated gluten networks was investigated by means of rheometry combined with μ-computed tomography (μ-CT) imaging. Stress relaxation behavior was followed over a wide temperature range (0-70°C). Modulation of intermolecular bonds was achieved with urea or ascorbic acid in an effort to elucidate the presiding intermolecular interactions over gluten network relaxation. Master curves of viscoelasticity were constructed, and relaxation spectra were computed revealing three relaxation regimes for all samples. Relaxation commences with a welldefined short-time regime where Rouse-like modes dominate, followed by a power law region displaying continuous relaxation concluding in a terminal zone. In the latter zone, poroelastic relaxation due to water migration in the nanoporous structure of the network also contributes to the stress relief in the material. Hydrogen bonding between adjacent protein chains was identified as the determinant force that influences the relaxation of the networks. Changes in intermolecular interactions also resulted in changes in microstructure of the material that was also linked to the relaxation behavior of the networks.

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“…The parameters H and M characterize the coupling between solid and fluid stress and strain. This model was originally developed for soil mechanics and it was then applied to describe the mechanics of hydrogels [71] and tissues such as bone [72] and cartilage [73]. Very recently, it has also been applied to cell mechanics [24].…”

Section: Poroelastic Modelmentioning

confidence: 99%

Nanobiomechanics of living cells: a review

Chen

2014

Interface Focus.

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Nanobiomechanics of living cells is very important to understand cellmaterials interactions. This would potentially help to optimize the surface design of the implanted materials and scaffold materials for tissue engineering. The nanoindentation techniques enable quantifying nanobiomechanics of living cells, with flexibility of using indenters of different geometries. However, the data interpretation for nanoindentation of living cells is often difficult. Despite abundant experimental data reported on nanobiomechanics of living cells, there is a lack of comprehensive discussion on testing with different tip geometries, and the associated mechanical models that enable extracting the mechanical properties of living cells. Therefore, this paper discusses the strategy of selecting the right type of indenter tips and the corresponding mechanical models at given test conditions.

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Separating poroviscoelastic deformation mechanisms in hydrogels

Cited by 87 publications

References 23 publications

Mechanical measurements of heterogeneity and length scale effects in PEG-based hydrogels

Mechanical measurements of heterogeneity and length scale effects in PEG-based hydrogels

Influence of supramolecular forces on the linear viscoelasticity of gluten

Nanobiomechanics of living cells: a review

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