Separating function from structure in perfusion imaging of the aging brain

Asllani, Iris; Habeck, Christian; Borogovac, Ajna; Brown, Truman R.; Brickman, Adam M.; Stern, Yaakov

doi:10.1002/hbm.20719

Cited by 87 publications

(90 citation statements)

References 34 publications

(52 reference statements)

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“…In the current study, a direct relationship was observed between age and normative fitness, whereby younger participants exhibited poorer fitness relative to their peers than older participants. CBF in the precuneus declines with aging (Asllani et al 2009), and thus an age effect may have contributed to the inverse relationship between normative fitness and CBF.…”

Section: Discussionmentioning

confidence: 98%

Exercise intensity modulates the change in cerebral blood flow following aerobic exercise in chronic stroke

et al. 2015

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The mechanisms supporting functional improvement by aerobic exercise following stroke remain incompletely understood. This study investigated how cycling intensity and aerobic fitness influence cerebral blood flow (CBF) following a single exercise session. Thirteen community-living stroke survivors performed 20 min of semi-recumbent cycling at low and moderate intensities (40-50 and 60-70 % of heart rate reserve, respectively) as determined from an exercise stress test. CBF was quantified by arterial spin labeling MRI at baseline, as well as 30 and 50 min post-exercise. An intensity-dependent effect was observed in the right post-central and supramarginal gyri up to 50 min after exercise (uncorrected p < 0.005, cluster size ≥10). Regional CBF was increased 18 ± 17 % and reduced 8 ± 12 % following moderate- and low-intensity cycling, respectively. In contrast, CBF changes were similar between sessions in the right lentiform nucleus and mid-frontal gyrus, as well as the left temporal and parietal gyri. Aerobic fitness was directly related to posterior cingulate and thalamic CBF, and inversely related to precuneal CBF at rest (R (2) ≥ 0.75); however, no relationship between fitness and the post-exercise change in CBF was observed. Divergent changes in regional CBF were observed in the right parietal cortex following low- and moderate-intensity exercise, which suggests that intensity of prescribed exercise may be useful in optimizing rehabilitation.

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Section: Discussionmentioning

confidence: 98%

Exercise intensity modulates the change in cerebral blood flow following aerobic exercise in chronic stroke

et al. 2015

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“…But if a structural difference or some baseline blood flow difference is detected, how can we know whether these facts explain the BOLD signal differences? Moreover, if the size of the particular structure implicated is taken into account (Asllani et al, 2009), if different baseline levels that have been shown to affect the BOLD response are controlled for, if hormonal factors are balanced out, if contextual factors are manipulated, if. .…”

Section: Discussionmentioning

confidence: 99%

A review on sex differences in processing emotional signals

2012

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a b s t r a c tInterest in sex-related differences in psychological functioning has again come to the foreground with new findings about their possible functional basis in the brain. Sex differences may be one way how evolution has capitalized on the capacity of homologous brain regions to process social information between men and women differently. This paper focuses specifically on the effects of emotional valence, sex of the observed and sex of the observer on regional brain activations. We also discuss the effects of and interactions between environment, hormones, genes and structural differences of the brain in the context of differential brain activity patterns between men and women following exposure to seen expressions of emotion and in this context we outline a number of methodological considerations for future research. Importantly, results show that although women are better at recognizing emotions and express themselves more easily, men show greater responses to threatening cues (dominant, violent or aggressive) and this may reflect different behavioral response tendencies between men and women as well as evolutionary effects. We conclude that sex differences must not be ignored in affective research and more specifically in affective neuroscience.

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“…5,6 In these previous ASL studies, no age-specific postlabeling delay was used, and the postlabeling delays that were used ranged from 800 to 1700 ms. PET and SPECT studies have revealed similar results. 9,10 Our findings confirm that pCBF decreases with age in healthy adults.…”

Section: Discussionmentioning

confidence: 99%