Separate orexigenic hippocampal ensembles shape dietary choice by enhancing contextual memory and motivation
Mingxin Yang,
Arashdeep Singh,
Molly McDougle
et al.
Abstract:The hippocampus (HPC), traditionally known for its role in learning and memory, has emerged as a controller of food intake. While prior studies primarily associated the HPC with food intake inhibition, recent research suggests a critical role in appetitive processes. We hypothesized that orexigenic HPC neurons differentially respond to fats and/or sugars, potent natural reinforcers that contribute to obesity development. Results uncover previously-unrecognized, spatially-distinct neuronal ensembles within the … Show more
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