Separate aftereffects of morning and evening exercise on ambulatory blood pressure in prehypertensive men

Rezende, Rodrigo Alvarenga; Mendes, Caroline Antonelli; Silva‐Júnior, Natan; Tinucci, Taís; Cipolla‐Neto, José; Forjaz, C. L. M.

doi:10.23736/s0022-4707.17.06964-x

Cited by 8 publications

(13 citation statements)

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“…In addition, the last meta-analysis did not find difference in PEH whether aerobic exercise is performed continuously, intermittently or increasingly [15]. Finally, recent studies have observed that BP reduction is greater after a session of exercise performed in the afternoon [35,36] and evening [37,38] than in the morning in comparison to preexercise levels. In contrast, when a control day is considered for analysis, the net effect of PEH is greater after morning than evening exercise due to the morning exercise blunts the circadian pattern of increasing BP observed in the control day beyond to decrease BP in the exercise day [38].…”

Section: Factors Of Influence On Pehmentioning

confidence: 87%

Postexercise hypotension as a clinical tool: a “single brick” in the wall

Brito

Fecchio

Peçanha

et al. 2018

Journal of the American Society of Hypertension

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Section: Factors Of Influence On Pehmentioning

confidence: 87%

Postexercise hypotension as a clinical tool: a “single brick” in the wall

Brito

Fecchio

Peçanha

et al. 2018

Journal of the American Society of Hypertension

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“…Five studies examined the association between time-of-day for exercise and BP [55][56][57][58][59]. Of these, two studies used a randomized controlled trial [55,58], and three used a randomized crossover design that were evaluated as pre-post designs for quality review [56,57,59]. Both randomized trials earned a study quality rating of 'poor'.…”

Section: Time-of-day For Exercise Study Quality and Characteristicsmentioning

confidence: 99%

“…The three randomized crossover studies were rated as 'poor' (n ¼ 1) [56], 'fair' (n ¼ 1) [57], and 'good' (n ¼ 1) [59] (see Supplementary Table 2c, http://links.lww.com/HJH/C449). Time-of-day for exercise was operationalized via supervised exercise training sessions performed in the morning (7 : 00-9 : 00 [55]; 9 : 00-10 : 00 [56]; 7 : 00-11 : 30 [57]; 6 : 30-8 : 30 [58]; 7 : 00-7 : 30 [59]), afternoon (13 : 00-13 : 30 [59]), or evening (18 : 00-20 : 00 [55,58]; 18 : 30-19 : 15 [56]; 17 : 00-21 : 00 [57]; 19 : 00-19 : 30 [59]) as part of interventions lasting 3 days [59], 6 days [56,57], 10 weeks [55], or 12 weeks [58]. Resting BP (n ¼ 2/5) or 24-h ambulatory methods (n ¼ 3/5) were utilized in these studies.…”

Section: Time-of-day For Exercise Study Quality and Characteristicsmentioning

confidence: 99%

Association between time-of-day for eating, exercise, and sleep with blood pressure in adults with elevated blood pressure or hypertension: a systematic review

Keiser,

Katz,

Robson

et al. 2024

Journal of Hypertension

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The purpose of this review is to synthesize results from studies examining the association between time-of-day for eating, exercise, and sleep with blood pressure (BP) in adults with elevated BP or hypertension. Six databases were searched for relevant publications from which 789 were identified. Ten studies met inclusion criteria. Four studies examined time-of-day for eating, five examined time-of-day for exercise, and one examined time-of-day for sleep and their associations with BP. Results suggested that later time-of-day for eating (n = 2/4) and later sleep mid-point (n = 1/1) were significantly related to higher BP in multivariable models, whereas morning (n = 3/5) and evening (n = 4/5) exercise were associated with significantly lower BP. Although this small body of work is limited by a lack of prospective, randomized controlled study designs and underutilization of 24 h ambulatory BP assessment, these results provide preliminary, hypothesis-generating support for the independent role of time-of-day for eating, exercise, and sleep with lower BP.

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“…In the A549 NSCLC cell line, cucurbitacin I suppress ERK activation and downstream p-mTOR and p-STAT3. 54 An alkaloid matrine is found in the traditional Chinese herb Sophora flavescens Ait. In lung cancer, 95D, and A549 cells, matrine reduced cell growth and caused apoptosis in a dose-and time-dependent manner.…”

Section: A Preclinical and In Vitro Studies On Pi3k/ Akt/mtor Inhibit...mentioning

confidence: 99%

PI3K/Akt/mTOR Pathways Inhibitors with Potential Prospects in Non-Small-Cell Lung Cancer

Alharbi

Samuel

Thangavelu

et al. 2022

J Environ Pathol Toxicol Oncol

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Lung cancer is the leading cause of cancer-related mortality across the globe. The most prevalent pathological form of lung cancer is non-small-cell lung cancer (NSCLC). Elevated stimulation of the PI3K/Akt/mTOR pathway causes a slew of cancer-related symptoms, making it a promising target for new anticancer drugs. The PI3K/Akt/mTOR path is involved extensively in carcinogenesis and disease advancement in NSCLC. Several new inhibitors targeting this pathway have been discovered in preclinical investigations and clinical trials. The etiology and epidemiology of NSCLC and biology of the PI3K/Akt/mTOR cascade and its role in NSCLC pathogenesis have all been discussed in this article. In this article, we've reviewed PI3K/Akt/mTOR cascade inhibitors that have been proven in vitro and in preclinical trials to be effective in NSCLC. Drugs targeting the PI3K/Akt/mTOR path in the treatment of NSCLC were also addressed. A better knowledge of the underlying molecular biology, including epigenetic changes, is also critical to detecting relevant biomarkers and guiding combination methods. Additionally, improved clinical trial designs will increase the capacity to test novel drugs and combinations for accounting for genomic variation and eventually improve patient outcomes.

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Separate aftereffects of morning and evening exercise on ambulatory blood pressure in prehypertensive men

Cited by 8 publications

References 0 publications

Postexercise hypotension as a clinical tool: a “single brick” in the wall

Postexercise hypotension as a clinical tool: a “single brick” in the wall

Association between time-of-day for eating, exercise, and sleep with blood pressure in adults with elevated blood pressure or hypertension: a systematic review

PI3K/Akt/mTOR Pathways Inhibitors with Potential Prospects in Non-Small-Cell Lung Cancer

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