The evaluation of the failure probability of corroded pipelines is an important calculation to quantify the risk assessment and integrity of pipelines. Traditional Monte Carlo simulation method has been widely used to solve this type of problems, where it generates a very large number of simulations and takes longer time in computing. In this study, enhanced computational method called Separable Monte Carlo is employed to evaluate the time-dependent reliability of pipeline segments containing active corrosion defects, where a practical example was used. The results show that the Separable Monte Carlo simulation method not only minimizes the computational cost strongly but also improves the calculation precision.