SEOM Clinical Guideline in ovarian cancer (2016)

Abstract

Despite remarkable advances in the knowledge of molecular biology and treatment, ovarian cancer (OC) is the first cause of death due to gynecological cancer and the fifth cause of death for cancer in women in Spain. The aim of this guideline is to summarize the current evidence and to give evidence-based recommendations for clinical practice.

Resveratrol inhibits the proliferation and induces the apoptosis in ovarian cancer cells via inhibiting glycolysis and targeting AMPK/mTOR signaling pathway

“…Ovarian cancer is the most lethal gynecologic malignancy and 5‐year survival rate is only 30% for advanced patients due to late‐stage diagnosis and relapse after chemotherapy . Aerobic glycolysis (Warburg effect) also promotes the malignancy of cancer .…”

“…Ovarian cancer is the most lethal gynecologic malignancy and 5-year survival rate is only 30% for advanced patients due to late-stage diagnosis and relapse after chemotherapy. 34 Aerobic glycolysis (Warburg effect) also promotes the malignancy of cancer. 5 Indeed, we found that anti-cancer efficacy of resveratrol for ovarian cancer cells is related to deceased glucose consumption and lactate production, consistent with previous study reporting that resveratrol selectively inhibited glucose uptake, and induced apoptosis in ovarian cancer cells by interrupting Akt regulated plasma membrane GLUT1 trafficking.…”

SEOM guidelines 2016: an update

“…Treatment options for the management of ovarian cancer have been also updated, including the most recent findings in biology and targeted therapies [5].…”

Anticuerpos conjugados a fármacos frente a receptores ERBB: nuevas indicaciones y mecanismos de resistencia

“…La cirugía habitualmente es un tratamiento importante para el cáncer de ovario, no solo a nivel terapéutico sino también para determinar el alcance de la enfermedad y estadificarla de manera precisa, ya que con las pruebas de imagen no se logra este objetivo. Existen varias opciones quirúrgicas para el cáncer de ovario, que van a estar determinadas por el estadio del tumor (Santaballa et al 2016). En tumores localizados o en estadios más tempranos se puede llevar a cabo la extirpación de los ovarios y las trompas de Falopio (salpingo-ooforectomía), del útero (histerectomía), de los ganglios linfáticos de la pelvis (linfadenectomía) o del tejido delgado que recubre el estómago y el intestino grueso (omentectomía).…”

“…La quimioterapia es la opción de tratamiento más frecuente en pacientes de cáncer de ovario y se administra en diversos momentos de la enfermedad (Santaballa et al 2016).…”