SEOM clinical guideline in nasopharynx cancer (2017)

Pastor, M.; Pousa, Antonio López; Barco, Elvira del; Segura, Pedro Pérez; Astorga, Beatriz Gonzalez; Castelo, Beatriz; Bonfill, Teresa; Martínez‐Trufero, Javier; Grau, Juan J.; Mesı́a, Ricard

doi:10.1007/s12094-017-1777-0

Cited by 31 publications

(22 citation statements)

References 18 publications

(16 reference statements)

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“…Based on this principle and clinical practice, platinum-based synchronous chemotherapy combined with radiotherapy is defined as the standard treatment of advanced nasopharyngeal carcinoma. This indicates that the high expression of miR-21 also indirectly causes radiotherapy resistance of nasopharyngeal carcinoma [61,62].…”

Section: Mirnas Participate In Radiotherapy Resistance Of Nasopharyngmentioning

confidence: 93%

MiRNAs in Radiotherapy Resistance of Nasopharyngeal Carcinoma

Tian¹,

Tang²,

Yi³

et al. 2020

J. Cancer

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Nasopharyngeal carcinoma (NPC) is one of the most common malignant tumors of the head and neck in Southeast Asia and southern China. Although the comprehensive treatment based on intensity-modulated radiation therapy improves outcomes, the five-year survival rate of NPC patients is low, and the recurrence remains high. Radiotherapy resistance is the main cause of poor prognosis in NPC patients. MicroRNAs (miRNAs) are a class of endogenous non-coding RNAs regulating various biological functions in eukaryotes. These miRNAs can regulate the development and progression of nasopharyngeal carcinoma by affecting the proliferation, apoptosis, movement, invasion and metastasis of NPC cells. The abnormal expression of miRNAs is closely related to radiotherapy sensitivity and prognosis of NPC patients, which can affect the transmission of related signaling pathways by regulating the expression of tumor suppressor genes and / or oncogenes, and therefore participate in radiotherapy resistance in nasopharyngeal carcinoma. Here, we review the mechanisms by which miRNAs may be involved in the radiotherapy resistance of nasopharyngeal carcinoma.

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Section: Mirnas Participate In Radiotherapy Resistance Of Nasopharyngmentioning

confidence: 93%

MiRNAs in Radiotherapy Resistance of Nasopharyngeal Carcinoma

Tian¹,

Tang²,

Yi³

et al. 2020

J. Cancer

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“…A total of 5*10 4 CNE2 cells were injected into the flanks of female nude mice. Mice were randomly divided into 4 groups when the tumors reached approximately 100-150 mm 3 . Group 1 was treated with DMSO as vehicle(Control) every other days, group 2 was treated with riluzole (10 mg/kg) by intraperitoneal injection(Riluzole) every other days.…”

Section: Murine Xenograft Modelmentioning

confidence: 99%

“…To date, radiotherapy remains the preferred treatment to cure nondisseminated disease. Platinum/gemcitabine-based chemotherapy is required to improve the rate of survival at all stages of metastatic disease [3]. Although radiotherapy is a powerful method for NPC, radiation-induced stress response and resistant gene expression could seriously undermine its effectiveness.…”

Section: Introductionmentioning

confidence: 99%

Riluzole Enhances the Response of Human Nasopharyngeal Carcinoma Cells to Ionizing Radiation via ATM/P53 Signalling Pathway

Sun

Jun

et al. 2020

J. Cancer

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Riluzole is approved by the FDA as an amyotrophic lateral sclerosis (ALS) drug. Previous studies showed that treatment with riluzole suppressed the proliferation of many cancer cells. However, little is known about its effects on nasopharyngeal carcinoma (NPC) and its molecular mode of action. In this study, we determined the effect of riluzole on apoptosis, cell cycle, migration, and invasion in NPC cell lines and investigated its mechanism at the molecular level. By using the human NPC cell lines CNE1, CNE2, and HNE1, we revealed that riluzole effectively inhibited viability of the NPC cell lines in dose-and time-dependent manners. Furthermore, riluzole dose-dependently induced apoptosis and G2/M cell cycle arrest in the NPC cell lines. After combination with radiotherapy (RT), greater cytotoxicity was achieved than with riluzole or RT alone in vitro and vivo. This was associated with the activation of ataxia telangiectasia mutated (ATM) and phosphoinositide p53 pathways. P53 silencing reduced cell reactiveness to riluzole therapy. These observations demonstrate that the riluzole-activated ATM/P53 pathway is directly involved in radiation-induced apoptosis of NPC cells. Given the acceptable side effect, combining of riluzole and radiotherapy is promising in NPC treatment.

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“…Collectively, these groups of malignancies are termed OCC-OPC in this chapter. Although nasopharyngeal cancers are located in the head and neck region, they have been excluded from being among OCC-OPC as a result of their distinct epidemiology, biology, and clinical behavior (Abdulamir et al 2008;Pastor et al 2018).…”

Section: Introductionmentioning

confidence: 99%

Oral and Oropharyngeal Cancer in Arab Nations

Kujan

Idrees

Farah

2019

Handbook of Healthcare in the Arab World

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Oral cavity and oropharyngeal cancer (OCC-OPC) is a major health burden worldwide. The Arab League constitutes 22 countries with a population exceeding 400 million living in a diverse geography extending from the Arabian Gulf in the East to the Atlantic Ocean in the West. This is the first report to analyze the epidemiology and etiology of OCC-OPC in the Arab region with an insight into current practices of preventive measures. Data were retrieved from the public database of the International Agency for Research on Cancer (GLOBOCAN 2018). Literature was searched to report the associated risk factors and prevention

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SEOM clinical guideline in nasopharynx cancer (2017)

Cited by 31 publications

References 18 publications

MiRNAs in Radiotherapy Resistance of Nasopharyngeal Carcinoma

MiRNAs in Radiotherapy Resistance of Nasopharyngeal Carcinoma

Riluzole Enhances the Response of Human Nasopharyngeal Carcinoma Cells to Ionizing Radiation via ATM/P53 Signalling Pathway

Oral and Oropharyngeal Cancer in Arab Nations

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