Sentinel surveillance of invasive candidiasis in Spain: epidemiology and antifungal susceptibility

Nieto, M C; Tellería, O.; Cisterna, R

doi:10.1016/j.diagmicrobio.2014.05.021

Cited by 33 publications

(21 citation statements)

References 41 publications

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“…Candida albicans is an important opportunistic fungus that causes a wide variety of diseases in patients, ranging from the superficial mucocutaneous candidiasis (affecting the nails, skin, and oral and genital mucosae) to life-threatening disseminated infections [1,2]. In patient in critical care, candidemia is the most important fungi disease with a 30% mortality rate [3]. The C. albicans’ cell wall maintains structural integrity and acts as intermediate between the cell and the environment.…”

Section: Introductionmentioning

confidence: 99%

Candida albicans cell shaving uncovers new proteins involved in cell wall integrity, yeast to hypha transition, stress response and host–pathogen interaction

Gil-Bona

Parra-Giraldo

Hernáez

et al. 2015

Journal of Proteomics

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The ability to switch from yeast to hyphal growth is essential for virulence in Candida albicans. The cell surface is the initial point of contact between the fungus and the host. In this work, a free-gel proteomic strategy based on tryptic digestion of live yeast and hyphae cells and protein identification using LC-MS/MS methodology was used to identify cell surface proteins. Using this strategy, a total of 943 proteins were identified, of which 438 were in yeast and 928 were in hyphae. Of these proteins, 79 were closely related to the organization and biogenesis of the cell wall, including 28 GPI-anchored proteins, such as Hyr1 and Sod5 which were detected exclusively in hyphae, and Als2 and Sap10which were detected only in yeast. A group of 17 proteins of unknown function were subsequently studied by analysis of the corresponding deletion mutants. We found that four new proteins, Pst3, Tos1, Orf19.3060 and Orf19.5352 are involved in cell wall integrity and in C. albicans’ engulfment by macrophages. Moreover, the putative NADH-ubiquinone-related proteins, Ali1, Mci4, Orf19.287 and Orf19.7590, are also involved in osmotic and oxidative resistance, yeast to hypha transition and the ability to damage and invade oral epithelial cells.

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Section: Introductionmentioning

confidence: 99%

Candida albicans cell shaving uncovers new proteins involved in cell wall integrity, yeast to hypha transition, stress response and host–pathogen interaction

Gil-Bona

Parra-Giraldo

Hernáez

et al. 2015

Journal of Proteomics

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“…3 Department of Laboratory Medicine, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, PR China. 4…”

Section: Acknowledgmentsmentioning

confidence: 99%

“…The incidence of invasive fungal infection (IFI), more than 50% of which is caused by C. albicans, has been steadily increasing and is the fourth most common cause of nosocomial bloodstream infection. This is in part due to invasive surgical operations, chemotherapy, radiotherapy, immunosuppressive therapy, and the wide use of broad-spectrum antibiotics and glucocorticoids [1][2][3][4][5]. IFI is a serious infectious disease with a high mortality rate; its diagnosis and treatment are difficult in the clinical setting [6−8] .…”

Section: Introductionmentioning

confidence: 99%

The role of HMGB1 in invasive Candida albicans infection

Wang

et al. 2020

Preprint

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Background: High mobility group box 1 (HMGB1), an important “late” inflammatory mediator, is a therapeutic target for bacterial sepsis. Ethyl pyruvate (EP) has anti-inflammatory effects, and prevents bacterial sepsis by decreasing HMGB1 levels. However, the role of HMGB1 in fungal sepsis is still unclear. Therefore, we investigated HMGB1 mRNA and protein levels in serum and tissue from patients and mice with invasive C. albicans infection. We explored the anti-HMGB1 effects of EP, which may be of benefit in the diagnosis and treatment of invasive C. albicans infections. Methods: We measured serum HMGB1 mRNA and protein levels in four different patient groups: 23 control subjects (group 1), 35 patients with sepsis without fungal infection (group 2), 35 patients with severe sepsis without fungal infection (group 3), and 23 patients with severe sepsis with C. albicans infection (group 4). We collected clinical indices to estimate correlations between HMGB1 levels and disease severity. Furthermore, we experimentally stimulated mice with C. albicans and C. albicans + EP, and examined HMGB1 mRNA and protein levels from serum and tissue. We determined liver and kidney functions, investigated pathological changes in tissues and assessed mortality. We also investigated serum levels of the proinflammatory cytokines, tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6) in these animals. Results: Serum HMGB1 mRNA and protein levels in patients with severe sepsis with C. albicans infection were elevated. Increased HMGB1 levels were correlated with procalcitonin (PCT), C-reactive protein (CRP), 1,3-β-D-Glucan (BDG) and C. albicans sepsis severity. HMGB1 mRNA and protein levels in serum and tissues were significantly increased within seven days after mice were infected with C. albicans. The administration of EP inhibited HMGB1 levels, decreased tissue damage, increased survival rates and inhibited the release of TNF-α and IL-6.Conclusions: Increased HMGB1 levels in patients with severe sepsis with C. albicans infection were positively correlated with PCT, CRP, BDG, and disease severity. EP prevented C. albicans lethality by decreasing HMGB1 expression and release. We suggest that HMGB1 plays a vital role in invasive C. albicans infections and may provide an effective diagnostic and therapeutic target for such infections in clinical settings.

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“…In the majority of the publications, physiological criteria were used or the methodologies used were not specified. Using this approach, the presence of D. hansenii has been described in patients infected by HIV (Nidhi et al., ; Ribeiro et al., ; Minea et al., ), with cancer (Li et al., ; Nidhi et al., ), with post‐operational acute respiratory distress syndrome (Mun et al., ), with invasive candidiasis (Ghahri et al., ; Wang et al., ; Jung et al., ; Nieto et al., ), in pregnant women in Malaysia hospital (Masri et al., ) or vulvovaginal candidiasis (Liu et al., ), in patients with fungal eye infections (Ghodasra et al., ), with psoriasis (Sarvtin et al., ), with chronic diarrhoea (Banerjee et al., ), athlete′s foot (Chan et al., ) and in children with neutropenia (Haddadi et al., ). The value of these reports is often limited considering the limitations of the identification method.…”

Section: Assessmentmentioning

confidence: 99%

“…Quite a few of the reports deemed relevant in the ELS (43) presented information demonstrating a low or very low prevalence (seldom above 5%) of K. marxianus among fungi (mainly Candida spp.) isolated from patients with various serious underlying diseases, like cancer or HIV, or other immunosuppressed states, and patients with catheters (de Freitas et al., ; Ghahri et al., ; Parmeland et al., ; Abrantes et al., ; Dufresne et al., ; Haddadi et al., ; Taj‐Aldeen et al., ; Youngster et al., ; Leuck et al., ; Menezes et al., ; Nidhi et al., ; Nieto et al., ; Sahin et al., ).…”

Section: Assessmentmentioning

confidence: 99%

Scientific Opinion on the update of the list of QPS‐recommended biological agents intentionally added to food or feed as notified to EFSA†

Ricci¹,

Allende²,

Bolton³

et al. 2017

EFS2

223

135

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EFSA is requested to assess the safety of a broad range of biological agents in the context of notification for market authorisation as sources of food and feed additives, food enzymes and plant protection products. The qualified presumption of safety (QPS) assessment was developed to provide a harmonised generic preassessment to support safety risk assessments performed by EFSA's scientific Panels. The safety of unambiguously defined biological agents (at the highest taxonomic unit appropriate for the purpose for which an application is intended), and the completeness of the body of knowledge are assessed. Identified safety concerns for a taxonomic unit are, where possible and reasonable in number, reflected as 'qualifications' in connection with a recommendation for a QPS status. The list of QPS recommended biological agents was reviewed and updated in the current opinion and therefore becomes the valid list. The 2016 update reviews previously assessed microorganisms including bacteria, yeasts and viruses used for plant protection purposes following an Extensive Literature Search strategy. The taxonomic units related to the new notifications received since the 2013 QPS opinion, were periodically evaluated for a QPS status and the results published as Statements of the BIOHAZ Panel. Carnobacterium divergens, Lactobacillus diolivorans, Microbacterium imperiale, Pasteuria nishizawae, Pediococcus parvulus, Bacillus flexus, Bacillus smithii, Xanthomonas campestris and Candida cylindracea were recommended for the QPS list. All taxonomic units previously recommended for the 2013 QPS list had their status reconfirmed as well their qualifications with the exception of Pasteuria nishizawae for which the qualification was removed. The exclusion of filamentous fungi and enterococci from the QPS evaluations was reconsidered but monitoring will be maintained and the status will be re-evaluated in the next QPS Opinion update. Evaluation of bacteriophages should remain as a case-by-case procedure and should not be considered for QPS status. Acknowledgements: The BIOHAZ Panel wishes to thank the EFSA staff member: Mirena Ivanova for the support provided to this scientific output.

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Sentinel surveillance of invasive candidiasis in Spain: epidemiology and antifungal susceptibility

Cited by 33 publications

References 41 publications

Candida albicans cell shaving uncovers new proteins involved in cell wall integrity, yeast to hypha transition, stress response and host–pathogen interaction

Candida albicans cell shaving uncovers new proteins involved in cell wall integrity, yeast to hypha transition, stress response and host–pathogen interaction

The role of HMGB1 in invasive Candida albicans infection

Scientific Opinion on the update of the list of QPS‐recommended biological agents intentionally added to food or feed as notified to EFSA†

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