Sentinel node biopsy in vulvar cancer: Implications for staging

Oonk, Maaike H. M.; Hollema, Harmen; Zee, van der Aukje

doi:10.1016/j.bpobgyn.2015.03.007

Cited by 13 publications

(5 citation statements)

References 55 publications

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“…Patients with early stage VSCC have a 25% risk of lymph node metastases at the time of diagnosis. Sentinel lymph node mapping, a non-tumor specific imaging technique, is used for the detection of lymph node metastases in these patients [66]. The detection of lymph node metastases by targeted optical imaging could result in a further reduction of surgery-related morbidity.…”

Section: Discussionmentioning

confidence: 99%

Potential targets for tumor-specific imaging of vulvar squamous cell carcinoma: A systematic review of candidate biomarkers

Huisman

Burggraaf

Vahrmeijer

et al. 2020

Gynecologic Oncology

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Section: Discussionmentioning

confidence: 99%

Potential targets for tumor-specific imaging of vulvar squamous cell carcinoma: A systematic review of candidate biomarkers

Huisman

Burggraaf

Vahrmeijer

et al. 2020

Gynecologic Oncology

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“…Histological examination of the sentinel lymph node is representative for all other lymph nodes in the area, and histologically, a negative sentinel lymph node means the absence of metastases in subsequent lymph nodes. [16][17][18][19] The sentinel lymph node is marked in two ways, with a nanocolloid bound to 99mTc (Technetium) and with a patent blue. This method is the most reliable, as the sentinel lymph node is found in 97.7% of cases.…”

Section: Surgical Treatmentmentioning

confidence: 99%

Modern treatment of vulvar cancer

Merlo

2020

Radiology and Oncology

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BackgroundVulvar cancer accounts for 3–5% of malignant diseases of the female genital tract. The Slovenian incidence rate is 5.5/100,000, which means 57 new cases per year. The most common histological type (90%) is squamous cell carcinoma. Based on etiology, it can be classified into the first type which correlates with human papillomavirus (HPV) infection and the second type which is not associated with HPV. The most common and long-lasting symptom of vulvar cancer is pruritus. The preferred diagnostic procedure to confirm the diagnosis is a punch or incision biopsy. Surgery in combination with radiotherapy is the standard treatment for vulvar cancer. Sentinel lymph node biopsy with lymphoscintigraphy is now a standard part of surgical treatment. Chemotherapy is a palliative treatment option.ConclusionsVulvar cancer is a rare disease. Because of the pathogenesis, surgery and radiotherapy are the main treatment modalities. The sentinel node biopsy (SNB) represents a contemporary approach to the vulvar cancer treatment and significantly reduces morbidity. Improvements in treatment of vulvar cancer contributed to the decrease of mortality among Slovenian women.

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“…Further studies are needed to determine the clinical consequences of the size of the SLN metastases. 35 From a practical point of view, we have extensive experience in the use of technetium as a tracer. However, there are already studies that have shown that indocyanine green has a similar sensitivity, so it should be evaluated in new protocols in order to can incorporate it into our usual practice.…”

Section: Vulvamentioning

confidence: 99%

“…Frequently, at diagnosis the tumor is limited to the cervix, around 47% according to OonK. 35 The usual approach of these patients goes through radical hysterectomy or trachelectomy with bilateral pelvic lymphadenectomy. 1,37 This has achieved a high survival at 5 years when it comes to early stages.…”

Section: Cervixmentioning

confidence: 99%