Sentinel-node biopsy in early-stage ovarian cancer: preliminary results of a prospective multicentre study (SELLY)

Gynaecological malignancies and sentinel lymph node mapping: an update

“…variability in injection site, tracer used, interval to SLN detection, time to staging completion) and cohort size . The overall SLN detection rate is 90.3% (40–100%), with higher detection rates observed with use of indocyanine green (93%) increasing to 100% when indocyanine green was combined with radiocolloid . SLN detection was also improved by peritoneal injection of tracer (ovarian ligaments, mesovarium, ovarian hilum) compared to injection in the ovarian cortex and in patients who received immediate staging.…”

“…Lymph node status is relevant for prognostic and therapeutic stratification in early ovarian carcinoma, yet para‐aortic and pelvic lymphadenectomies are linked to increased intra‐ and post‐operative morbidity . LN metastases occur in up to 30% of clinically early‐stage ovarian carcinoma, isolated to para‐aortic LNs in half of cases but involving pelvic and para‐aortic LNs or pelvic LNs alone in 30% and 20% of cases, respectively .…”

“…Lymph node status is relevant for prognostic and therapeutic stratification in early ovarian carcinoma, yet para‐aortic and pelvic lymphadenectomies are linked to increased intra‐ and post‐operative morbidity . LN metastases occur in up to 30% of clinically early‐stage ovarian carcinoma, isolated to para‐aortic LNs in half of cases but involving pelvic and para‐aortic LNs or pelvic LNs alone in 30% and 20% of cases, respectively . For most cases of ovarian carcinoma, pre‐operative imaging has low sensitivity in detecting LN metastases; therefore, lymphadenectomy has remained the standard of care with the exception of well‐differentiated mucinous carcinoma, where the risk of LN metastasis is very low .…”

“…LN metastases occur in up to 30% of clinically early‐stage ovarian carcinoma, isolated to para‐aortic LNs in half of cases but involving pelvic and para‐aortic LNs or pelvic LNs alone in 30% and 20% of cases, respectively . For most cases of ovarian carcinoma, pre‐operative imaging has low sensitivity in detecting LN metastases; therefore, lymphadenectomy has remained the standard of care with the exception of well‐differentiated mucinous carcinoma, where the risk of LN metastasis is very low . SLN mapping is emerging as a potential alternative to lymphadenectomy in early‐stage ovarian carcinoma …”

“…Currently, the experience with sentinel node mapping in early ovarian carcinoma is limited to feasibility studies which have differed with respect to ovarian pathology, methodology (i.e. variability in injection site, tracer used, interval to SLN detection, time to staging completion) and cohort size . The overall SLN detection rate is 90.3% (40–100%), with higher detection rates observed with use of indocyanine green (93%) increasing to 100% when indocyanine green was combined with radiocolloid .…”