Sentinel node biopsy for the management of early stage endometrial cancer: Long-term results of the SENTI-ENDO study

Daraı̈, Émile; Dubernard, Gil; Bats, Anne-Sophie; Heitz, D; Mathevet, Patrice; Marret, H.; Querleu, Denis; Golfier, François; Leblanc, Éric; Rouzier, Roman; Ballester, Marcos

doi:10.1016/j.ygyno.2014.09.011

Cited by 129 publications

(95 citation statements)

References 26 publications

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“…Omitting patients who need lymphadenectomy carries a risk of inadequate staging, leading to secondary lymphadenectomy or systematic adjuvant radiotherapy [18]. Discrepancy rates have been stated as up to 33% in some studies [19]. However, as shown in our study, the high sensitivity of PET/CT for discriminating high-and low-risk patients can be useful for determining candidates for lymphadenectomy.…”

Section: Discussionmentioning

confidence: 63%

Prognostic value of 18F-FDG PET/CT for identifying high- and low-risk endometrial cancer patients

Özgü

Öz²,

Yıldız³

et al. 2016

Ginekol Pol

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Objectives: To assess the usefulness of adding PET/CT as a preoperative test for determining the extent of endometrial cancer and discriminating low-and high-risk patients to identify candidates for surgical staging. Material and methods:We retrospectively reviewed 86 patients with pathologically proven endometrial cancer who had undergone preoperative 18 F-FDG PET/CT. The prognostic relationships between PET/CT parameters and pathology reports were assessed. Results:The SUV max was significantly higher in patients with FIGO stage IB or higher compared with those with stage IA; for stage III-IV compared with stage I-II; and for patients with lymph node metastasis compared with those without lymph node metastasis. Using 6.70 as a cut-off for SUV max , low-risk patients can be identified with a sensitivity of 92.9%. Conclusions:PET/CT imaging can be used not only for determining malignancy and lymph node involvement but also for determining candidates for surgical staging with high sensitivity.

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Section: Discussionmentioning

confidence: 63%

Prognostic value of 18F-FDG PET/CT for identifying high- and low-risk endometrial cancer patients

Özgü

Öz²,

Yıldız³

et al. 2016

Ginekol Pol

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“…When SLN is positive in the frozen section evaluation, a complete PLA and PALA for the detection of the non-SLN status is recommended. 38,39 On the other hand, in their recent study, Touhami et al 40 found that the size of the metastasis within the SLN can predict the risk of non-SLN metastasis. If the tumor size within the SLN is 2 mm or smaller, the risk of having another positive pelvic lymph node is 5% (1 in 20 patients), when compared with the cases with tumor sizes within the SLN of greater than 2 mm carrying a 60.8% risk of another positive pelvic lymph node (P G 0.0001).…”

Section: Discussionmentioning

confidence: 98%

The Combination of Preoperative Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography and Sentinel Lymph Node Mapping in the Surgical Management of Endometrioid Endometrial Cancer

Beşe¹,

Sal

Demirkıran

et al. 2016

Int J Gynecol Cancer

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“…Lymphovascular space invasion (LVSI) correlates with LN involvement, and is reported to be a predictor of prognosis (Guntupalli et al 2012). Recent medical advances in detecting micrometastases have resulted in developing minimally invasive surgery techniques that induces the higher quality of postoperative life, but such procedures rely on the diagnosis of the perioperative biopsies (Daraï et al 2015). The accuracy of LN metastasis detection using computed tomography (CT), magnetic resonance imaging (MRI), ultrasonography (US) or 18F-2-fluoro-2-deoxy-D-glucose-positron emission tomography-CT (PET-CT) is not clinically satisfactory (Pelikan et al 2013).…”

Section: Introductionmentioning

confidence: 99%

CRP 1846C>T Genetic Polymorphism Is Associated with Lymph Node Metastasis and/or Severe Lymphatic Invasion in Endometrial Cancer

Kito

Motoyama

Fujita

et al. 2015

Tohoku J. Exp. Med.

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Endometrial cancer (EC) rates are rising in Japan. Lymph node (LN) metastasis is an important prognostic factor in EC, and its risk is increased with higher tumor grade, deep myometrial invasion, larger tumor size, and lymphovascular space invasion (LVSI). Current methodologies to assess these factors are unreliable. We previously showed the association between C-reactive protein (CRP) 1846C>T (rs1205) polymorphism and LN metastasis in esophageal, non-small cell lung, and breast cancers. The CRP gene is located on chromosome 1q21-q23, and the polymorphism in the noncoding region (1846C>T) of this gene decreases serum CRP levels. We investigated the relationship between CRP 1846C>T genetic polymorphism and LN metastasis or LVSI in 130 EC patients using polymerase chain reaction-restriction fragment length polymorphism. The CRP 1846C/T genotype was C/C in 11 patients, C/T in 58 patients and T/T in 61 patients. The patients were divided into two groups based on their CRP 1846 genotypes: "C/C" and "C/T + T/T". Nine (7%) and 18 (13%) patients, all with the polymorphism, had LN metastasis and moderate or prominent lymphatic invasion, respectively. LN metastasis and/or severe lymphatic invasion were observed in the C/T + T/T group, while patients with the C/C genotype had no LN metastases or severe lymphatic invasion. Univariate and multivariate logistic regression models revealed that the C/T + T/T patients had a significant likelihood of developing LN metastasis and/or severe lymphatic invasion. Our results suggest that CRP genetic polymorphism is a novel risk predictor of LN metastasis and/or lymphatic invasion in EC.

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Sentinel node biopsy for the management of early stage endometrial cancer: Long-term results of the SENTI-ENDO study

Cited by 129 publications

References 26 publications

Prognostic value of 18F-FDG PET/CT for identifying high- and low-risk endometrial cancer patients

Prognostic value of 18F-FDG PET/CT for identifying high- and low-risk endometrial cancer patients

The Combination of Preoperative Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography and Sentinel Lymph Node Mapping in the Surgical Management of Endometrioid Endometrial Cancer

CRP 1846C>T Genetic Polymorphism Is Associated with Lymph Node Metastasis and/or Severe Lymphatic Invasion in Endometrial Cancer

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