Sentinel node biopsy and frozen section procedure in signet ring cell carcinoma of the eyelid and orbit

Pryds, Anders; Venzo, Alessandro; Heegaard, Steffen; Prause, Jan Ulrik; Toft, Peter Bjerre

doi:10.1111/aos.12252

Cited by 6 publications

(6 citation statements)

References 6 publications

(8 reference statements)

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“…Distant metastasis was seen in approximately half of both axillary and eyelid SRCHC cases [5/11 (45%) versus 2/4 (50%)]. In past cases in the literature, 2,3,5–7,14–51,54,55 the frequencies of distant metastasis [2/14 (14%) versus 5/43% (12%)] and death from disease [1/14 (7%) versus 3/43% (7%)] were almost equal between axillary and eyelid SRCHC cases. Conventional AC cases showed lymph node metastasis [3/8 (38%)] and death from disease with distant metastasis [1/8 (13%)] in this study.…”

Section: Discussionmentioning

confidence: 96%

“…However, our study indicated that lymph node metastasis is seen more frequently in axillary SRCHC cases than in eyelid SRCHC cases [8/11 (73%) versus 1/4 (25%)], even though eyelid SRCHC cases had larger tumours in our study. A literature review also revealed the predominance of axillary SRCHC [10/14 (71%) versus 8/43 (19%)] 2,3,5–7,14–51,54,55 . Distant metastasis was seen in approximately half of both axillary and eyelid SRCHC cases [5/11 (45%) versus 2/4 (50%)].…”

Section: Discussionmentioning

confidence: 98%

“…We performed a thorough search of the existing English‐language literature on SRCHC or other synonymous tumours by using the PubMed search engines, and found 14 axillary cases 4,6,7,9,10,14–22 and 43 eyelid cases 2,3,5,21–51 of SRCHC reported between 1975 and 2020 (Table ). Two axillary cases were excluded from this list because the two patients had a medical history of breast ILC 48 .…”

Section: Discussionmentioning

confidence: 99%

“…These were similar to those for conventional AC 52,53 . There were no SRCHC cases located in areas other than the axilla and eyelid 2,3,5–7,14–51,54,55 . Thus, metastasis should be considered for cases arising at other sites.…”

Section: Discussionmentioning

confidence: 99%

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Signet‐ring cell/histiocytoid carcinoma of the axilla: a clinicopathological and genetic analysis of 11 cases, review of the literature, and comparison with potentially related tumours

et al. 2021

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Aims The aim of this study was to determine the clinicopathological and genetic characteristics of axillary signet‐ring cell/histiocytoid carcinoma (SRCHC) and the relationship between axillary SRCHC, eyelid SRCHC, and conventional apocrine carcinoma (AC). Methods and results Eleven cases of axillary SRCHC, four cases of eyelid SRCHC, eight cases of axillary AC and five cases of invasive lobular carcinoma (ILC) were retrieved. Additionally, 14 axillary and 43 eyelid SRCHC cases from the literature were reviewed. Male predominance was prominent for axillary SRCHC (24:1) and eyelid SRCHC (42:5). Axillary SRCHC formed a circumscribed plaque or nodule, unlike eyelid SRCHC. Lymph node metastasis was predominantly seen in axillary SRCHC cases (72%, 18/25), but not in eyelid SRCHC cases (19%, 9/47). Axillary SRCHC and eyelid SRCHC were histopathologically similar and showed rare tubular formations. Immunoexpression of cytokeratin 7, cytokeratin 19, mucin 1, mucin 5AC, BerEP4 and androgen receptor was seen in all tested cases of the four diseases. Oestrogen and progesterone receptors were negative in both types of SRCHC and AC, but were strongly positive in ILCs. Complete loss of E‐cadherin expression was seen in approximately one‐quarter of both types of SRCHC and in all ILCs. PIK3CA mutations were detected in all three sequenced cases (two axillary SRCHCs and one eyelid SRCHC). Conclusion The histopathological, immunohistochemical and genetic findings suggest that both types of SRCHC are phenotypic variants of AC, although there are differences in sex, macroscopic findings and the frequency of lymph node metastasis among the three. In contrast, ILC differs from the other three tumour types.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Signet‐ring cell/histiocytoid carcinoma of the axilla: a clinicopathological and genetic analysis of 11 cases, review of the literature, and comparison with potentially related tumours

et al. 2021

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“…There are 32 reported cases of primary signet-ring cell/histiocytoid carcinoma in the English literature [1][2][3][4][5][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28]. Our case represents the 33th case of primary signet-ring cell/histiocytoid carcinoma of the eyelid in a 73 year old male, and illustrates the diagnostic and treatment challenges of this tumour.…”

Section: Discussionmentioning

confidence: 91%

Diagnostic and treatment challenges of a case of primary cutaneous signet-ring cell/histiocytoid carcinoma of the eyelid

2020

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Background Primary cutaneous signet-ring cell/histiocytoid carcinoma of the eyelid is an extremely rare but aggressive neoplasm diagnosed primarily in elderly men. Until now there are 32 published cases of signet-ring cell carcinoma or histiocytoid carcinoma of the eyelid. We report the clinical, radiographic and histological features of the 33rd reported case of PCSRCC in the eyelid of a 73-year-old male, and review diagnostic and treatment challenges of this rare entity. Case presentation Our case highlights a 73-year-old male who was referred for surgical correction of right eye ptosis that was present for 2 years. Upon assessment, he was noted to have an upper lateral orbital rim mass. Computed tomography (CT) noted ill-defined soft tissue thickening anterior to the right globe, predominantly pre-septal but with slight post-septal extension. The pathology revealed diffusely and deeply infiltrating tumour cells extending through the dermis, subcutis, orbicularis muscle bundles and nerve fibers; the tumour cells were noted to have a monotonous histiocytoid appearance with foamy granular eosinophilic cytoplasm. At high magnification, intracytoplasmic vacuoles and occasional intermixed signet ring cells were identified. Immunohistochemical staining revealed the tumour cells to be AE1/AE3, CK7, GCDFP-15, E-cadherin, androgen receptor stain and GATA3 positive. Final pathology report confirmed the diagnosis of primary cutaneous signet-ring cell/histiocytoid carcinoma. Further imaging failed to identify a distant primary malignancy or metastatic disease. The decision was made to attempt surgical excision of the tumor. After the bulk of the grossly apparent tumor was removed, intraoperative frozen sections were sent. Superficial biopsies of the right periorbital region were performed, which revealed extension significantly further than the gross disease. Thereafter, the patient underwent a wide orbital exenteration with reconstruction using a temporary split-thickness skin graft. Due to positive margins on final permanent sections, the patient underwent further wide resection with free muscle-skin flap reconstruction followed by adjuvant radiation treatment. Conclusion Our case represents the 33rd case of primary signet-ring cell/histiocytoid carcinoma of the eyelid in a 73-year-old male, the first documented case with GATA3 positivity and the second documented case with androgen receptor stain positivity.

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Primary Signet-Ring Cell/Histiocytoid Carcinoma of the Eyelid

Rongioletti

2014

Rare Malignant Skin Tumors

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Sentinel node biopsy and frozen section procedure in signet ring cell carcinoma of the eyelid and orbit

Cited by 6 publications

References 6 publications

Signet‐ring cell/histiocytoid carcinoma of the axilla: a clinicopathological and genetic analysis of 11 cases, review of the literature, and comparison with potentially related tumours

Signet‐ring cell/histiocytoid carcinoma of the axilla: a clinicopathological and genetic analysis of 11 cases, review of the literature, and comparison with potentially related tumours

Diagnostic and treatment challenges of a case of primary cutaneous signet-ring cell/histiocytoid carcinoma of the eyelid

Primary Signet-Ring Cell/Histiocytoid Carcinoma of the Eyelid

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