Sentinel lymph nodes in malignant tumors

Ермаков, А. В.; Сарибекян, Э. К.; Аблицова, Н. В.; Усов, Ф. Н.

doi:10.18027/2224-5057-2017-1-70-77

Cited by 5 publications

(4 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Оценка TILs в метастатических опухолевых поражениях, безусловно, является важнои� областью для будущих исследо-вании� , и имеющиеся в настоящее время данные свидетельствуют о том, что распределение TILs в лимфатических узлах может представлять прогностическую ценность [34]. Лимфатические узлы с метастазами имеют важные иммунологические и структурные отличия от узлов, не пораженных опухолевым процессом, еще до распространения первичного новообразования [35][36][37][38].…”

Section: Introductionunclassified

Assessment of cellular and humoral immunity in sentinel lymph node in breast cancer

Neryakhin

Gallyamov

Kamilianov

et al. 2022

jour

View full text Add to dashboard Cite

Introduction The morphofunctional status of the sentinel lymph node (SLN) is a prognostic factor of tumor metastasis. According to the modern concept, lymphagenic metastasis of the tumor is highest in the SLN, and in the absence of metastases in it, the probability of the absence of metastases in other lymph nodes is high. In the era of the development of new immune treatments for breast cancer, the identification of biomarkers that can predict the status of lymph nodes becomes an important task.The aim is immunohistochemical study of the expression level of T- and B-lymphocyte markers in breast cancer in the absence and presence of metastases in them.Materials and methods Sentinel lymph nodes without metastases and with metastases obtained during breast cancer surgery in 18 patients were studied using the immunohistochemical method.Results Comparative morphological analysis revealed that the number of CD3- and CD20-immunopositive cells was significantly higher in the SLN without metastases.Discussions The humoral and cellular immune systems take part in the antitumor immune response. Control over the growth of the tumor is carried out mainly by T cells. The results of our study showed a relatively high level of them in the SLN without metastatic lesion. The information about the antitumor activity of B-lymphocytes is contradictory since both the positive and negative role of B-cells in anticancer immunity is shown. The results of the studies showed that in the case of secondary foci of tumor growth, the number of CD20+ B cells is significantly lower, which indicates the important role of humoral immunity in addition to cell-mediated immunity in breast cancer.Conclusion Quantitative evaluation of (CD3+CD20) cells in the SLN can be used as a possible prognostic marker for breast tumor metastasis.

show abstract

Section: Introductionunclassified

Assessment of cellular and humoral immunity in sentinel lymph node in breast cancer

Neryakhin

Gallyamov

Kamilianov

et al. 2022

jour

View full text Add to dashboard Cite

show abstract

“…That is why the sentinel lymph node strategy is very actual in CRC surgery. It is the detection of the sentinel lymph node (SLN) that has an important prognostic value for determining further surgical management [1,7].…”

Section: Introductionmentioning

confidence: 99%

Rationale for extent of operation choice in rectal cancer

Nikitenko

Kosovan

Vorotyntseva

et al. 2021

J Educ Health Sport

View full text Add to dashboard Cite

Introduction. Colorectal cancer (CRC) remains relevant occupying one of the leading places in morbidity and mortality among oncological diseases. It reaches 13.5% in the structure of tumor diseases tending to increase. The aim of the work to improve the choice of surgical treatment management and reduce the number of intraoperative and postoperative complications in rectal cancer patients. Materials and methods. 184 operated patients with rectal cancer (RC) were divided into 2 groups: 1 group (patients with stage I RC (T1-2N0M0) and 2 group (stage II RC (T3N0M0)) who were carried out intraoperative detection and examination of sentinel lymph nodes. The volume and surgical approach depended on the stage and the presence of metastases (MTS). The average period of postoperative observation was 12–60 months, taking into account early (purulent-septic complications, bleeding, intestinal perforation) and distant (recurrence of rectal cancer) complications. Results. The patients of the 1 group had no MTS lesions of sentinel lymph nodes, due to this fact the surgical intervention was limited to transanal microsurgery. Among the complications were the following: bleeding – 2.2%; intraoperative perforation of the intestinal wall – 5.6%. No purulent-septic cases, no recurrences of rectal cancer were detected. In group 2, of 94 patients, 36 (38.3%) had MTS detected intraoperatively in sentinel lymph nodes which required a low anterior rectal resection with total mesorectomectomy. Among the complications was bleeding – 6.3%. No intraoperative perforations of the intestinal wall and no purulent-septic complications were detected. Recurrence of rectal cancer was detected in 12 (13.8%) patients. Conclusions. Performing transanal endoscopic resections in patients with RC I and especially stage II is possible only under the conditions of mandatory intraoperative staining and emergency histological examination of "sentinel" lymph nodes. The extent of surgical intervention is determined on the operating table based on the results of an emergency histological examination. When MTS lesions of the mesorectal "sentinel lymph nodes" are detected, the operation should be continued with mandatory mesorectomectomy.

show abstract

“…Минимальный объем хирургического лечения включает в себя радикальную вульвэктомию и билатеральную пахово-бедренную лимфаденэктомию. В настоящее время в клиническую практику начали активно внедряться методики детекции СЛУ [5][6][7]: контрастная лимфография и радионуклидный метод. J. Alex и D. Krag и D. Krag и соавт.…”

Section: Introductionunclassified

Current Techniques for Detecting Sentinel Lymph Nodes in Vulvar Cancer

Ганцев

Lipatov

Menshikov

2019

Kreativnaâ hirurgiâ i onkologiâ

View full text Add to dashboard Cite

Введение. Рак вульвы относится к группе редких новообразований и составляет около 4 % от всех гинекологических злокачественных опухолей. Одним из важных барьеров в распространении опухолевой клеточной популяции являются лимфатические узлы. Большинство онкологов признает факт существования так называемых сторожевых лимфатических узлов. Адекватная оценка состояния этого узла позволяет прогнозировать масштабы распространения рака, что, в свою очередь, обеспечивает результат хирургического лечения. Материалы и методы. На базе отделения онкогинекологии РКОД за период с 2015 по 2018 год получили хирургическое лечение 87 пациенток со злокачественными новообразованиями вульвы. У 19 пациенток с верифицированным раком вульвы произведена вульвэктомия с использованием детекции сторожевого лимфатического узла. Использовались методы контрастной лимфографии и непрямой интраоперационной радиоизотопной лимфосцинтиграфии. Отмечалось минимальное количество послеоперационных осложнений. Результаты. Основываясь на верификации сторожевого лимфоузла, оптимизировали объем хирургического лечения рака вульвы. Заключение. Детекция сторожевых лимфатических узлов при раке вульвы является эффективным методом планирования объема хирургического лечения, что, в свою очередь, снижает количество послеоперационных осложнений. Снижение количества послеоперационных осложнений благоприятно сказывается на качестве жизни пациенток.

show abstract

Sentinel lymph nodes in malignant tumors

Cited by 5 publications

References 18 publications

Assessment of cellular and humoral immunity in sentinel lymph node in breast cancer

Assessment of cellular and humoral immunity in sentinel lymph node in breast cancer

Rationale for extent of operation choice in rectal cancer

Current Techniques for Detecting Sentinel Lymph Nodes in Vulvar Cancer

Contact Info

Product

Resources

About