“…These patients at stage N1 8 will then receive adjuvant chemotherapy, leading to a better prognosis. [11][12][13] So far, sentinel node mapping has not been introduced as common practice for CRC, which is probably because of the overall disappointing sensitivity rates. 11 The aim of this retrospective study was to determine whether colonoscopic tattooing can increase the accuracy of tumor staging by analysis of the LN yield per specimen and its accuracy when used as a sentinel node procedure.…”
“…These patients at stage N1 8 will then receive adjuvant chemotherapy, leading to a better prognosis. [11][12][13] So far, sentinel node mapping has not been introduced as common practice for CRC, which is probably because of the overall disappointing sensitivity rates. 11 The aim of this retrospective study was to determine whether colonoscopic tattooing can increase the accuracy of tumor staging by analysis of the LN yield per specimen and its accuracy when used as a sentinel node procedure.…”
“…Many of the studies had populations with a relatively high BMI in keeping with Western colorectal practice. Previous attempts to undertake SLNM in colon cancer have used blue dye techniques, which have shown detection rates varying from 58 to 100% [31]. Liberale et al [32] investigated blue dye and NIR ICG SLNM in 20 patients with colonic malignancy.…”
Section: Resultsmentioning
confidence: 99%
“…Ex vivo studies in SLNM have defined that aberrant nodes lying outside of the usual mesenteric resection can occur in up to 10% of patients [31]. Saha et al [37] conducted a prospective study using methylene blue or isosulfan blue dye in open colorectal surgery.…”
Sentinel lymph node mapping (SLNM) may play a significant role in future delivery of colon cancer surgery because of an increase in early-stage, node-negative disease due to national bowel cancer screening programmes. Traditionally, colon lymphatic drainage has not been thought relevant as the operative approach cannot be tailored. Recent advances in local and endoscopic risk-reducing interventions for colonic malignancy have caused a rethink in approach. SLNM was initially attempted with blue dye techniques with limited success. Technological improvement has allowed surgeons to use near-infrared (NIR) light and NIR active tracers such as indocyanine green. This review provides an overview of the current status of intraoperative lymph node mapping in the colon, identifies challenges to the delivery of the techniques, and discusses potential solutions that may help SLNM play a role in improving the delivery of surgical care for patients with colon cancer.
“…The ex vivo SLN mapping, regarded as an easy technique, was considered most applicable in addition to conventional resection in colon cancer [78]. In a similar systematic review [79], analysis of data showed no significant difference in sensitivity between colon and rectal cancer. Also, there was no dependency of sensitivity on T stage for both colon and rectal cancer.…”
For patients undergoing curative resections for colon cancer, the nodal status represents the strongest prognostic factor, yet at the same time the most disputed issue as well. Consequently, the qualitative and quantitative aspects of lymph node evaluation are thus being scrutinized beyond the blunt distinction between ‘node positive' (pN+) and ‘node negative' (pN0) disease. Controversy ranges from a minimal or ‘least-unit' strategy as exemplified by the ‘sentinel node' to a maximally invasive or ‘all inclusive' approach by extensive surgery. Ranging between these two extremes of node sampling strategies are factors of quantitative and qualitative value, which may be subject to modification. Qualitative issues may include aspects of lymph node harvest reflected by surgeon, pathologist and even hospital performance, which all may be subject to modification. However, patient's age, gender and genotype may be non-modifiable, yet influence node sample. Quantitative issues may reflect the balance between absolute numbers and models investigating the relationships of positive to negative nodes (lymph node ratio; log odds of positive lymph nodes). This review provides an updated overview of the current controversies and a state-of-the-art perspective on the qualitative and quantitative aspects of using lymph nodes as a prognostic marker in colon cancer.
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