Sentinel lymph node imaging by a fluorescently labeled DNA tetrahedron

Kim, Kyoung Ran; Lee, Yong Deok; Lee, Taemin; Kim, Byeong Su; Kim, Sehoon; Ahn, Dae Ro

doi:10.1016/j.biomaterials.2013.03.074

Cited by 66 publications

(52 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This difference in temporal observation window obscures NP size-dependent effects. For example, LN imaging agents are transported quickly to the site to be imaged and must be cleared quickly to minimize toxicity [94]. NPs for this strategy, therefore, would be measured on the order of minutes.…”

Section: Size Of Nps Influences Their Biodistributionmentioning

confidence: 99%

Control of polymeric nanoparticle size to improve therapeutic delivery

Hickey

Santos

Williford

et al. 2015

Journal of Controlled Release

275

199

View full text Add to dashboard Cite

As nanoparticle (NP)-mediated drug delivery research continues to expand, understanding parameters that govern NP interactions with the biological environment becomes paramount. The principles identified from the study of these parameters can be used to engineer new NPs, impart unique functionalities, identify novel utilities, and improve the clinical translation of NP formulations. One key design parameter is NP size. New methods have been developed to produce NPs with increased control of NP size between 10 to 200 nm, a size range most relevant to physical and biochemical targeting through both intravascular and site-specific deliveries. Three notable techniques best suited for generating polymeric NPs with narrow size distributions are highlighted in this review: self-assembly, microfluidics-based preparation, and flash nanoprecipitation. Furthermore, the effect of NP size on the biological fate and transport properties at the molecular scale (protein-NP interactions) and the tissue and systemic scale (convective and diffusive transport of NPs) are analyzed here. These analyses underscore the importance of NP size control in considering clinical translation and assessment of therapeutic outcomes of NP delivery vehicles.

show abstract

Section: Size Of Nps Influences Their Biodistributionmentioning

confidence: 99%

Control of polymeric nanoparticle size to improve therapeutic delivery

Hickey

Santos

Williford

et al. 2015

Journal of Controlled Release

275

199

View full text Add to dashboard Cite

show abstract

“…TNDs can be further functionalized with nucleus‐targeting signaling peptides that directed their entry into the cellular nuclei, which advanced TDN‐based drug delivery nanocarriers for intracellular targeted therapy. Another study confirmed that TDN‐delivered DOX could reverse drug resistance in cancer cells with enhanced uptake and bypassing efflux process, whereas free DOX is virtually non‐cytotoxic due to the resistant …”

Section: Biomedical Applicationsmentioning

confidence: 86%

Programmable and Multifunctional DNA‐Based Materials for Biomedical Applications

et al. 2018

View full text Add to dashboard Cite

DNA encodes the genetic information; recently, it has also become a key player in material science. Given the specific Watson-Crick base-pairing interactions between only four types of nucleotides, well-designed DNA self-assembly can be programmable and predictable. Stem-loops, sticky ends, Holliday junctions, DNA tiles, and lattices are typical motifs for forming DNA-based structures. The oligonucleotides experience thermal annealing in a near-neutral buffer containing a divalent cation (usually Mg ) to produce a variety of DNA nanostructures. These structures not only show beautiful landscape, but can also be endowed with multifaceted functionalities. This Review begins with the fundamental characterization and evolutionary trajectory of DNA-based artificial structures, but concentrates on their biomedical applications. The coverage spans from controlled drug delivery to high therapeutic profile and accurate diagnosis. A variety of DNA-based materials, including aptamers, hydrogels, origamis, and tetrahedrons, are widely utilized in different biomedical fields. In addition, to achieve better performance and functionality, material hybridization is widely witnessed, and DNA nanostructure modification is also discussed. Although there are impressive advances and high expectations, the development of DNA-based structures/technologies is still hindered by several commonly recognized challenges, such as nuclease instability, lack of pharmacokinetics data, and relatively high synthesis cost.

show abstract

“…[82] In-vivo imaging/sensing Ahn et al used a fluorescence-labeled DNA tetrahedron for sentinel lymph nodes imaging. [83] Fan and coworkers built a multi-armed DNA tetrahedron containing a folic acid motif, an NIR emitter (Dylight 755), and a radioactive isotope ( 99m Tc) for tumor-targeting and dual-modality in-vivo imaging. [84] (Figure 5D) Krishnan et al constructed a DNA-icosahedra-based host-cargo complex for functional (a pH reporter) in vivo imaging [85] and on-demand release.…”

Section: In-vivo Cargo Deliverymentioning

confidence: 99%

Supramolecular Wireframe DNA Polyhedra: Assembly and Applications

Mao

Deng

2017

Chin. J. Chem.

View full text Add to dashboard Cite

Wireframe, polyhedral, supramolecular complexes made of DNA have uniform sizes, defined three-dimensional shapes, porous facets, hollow interiors, good biocompatibilities, and chemical functionalizability. They confer great potentials in bottom-up nanoengineering towards various applications. In this review, we summarize recent advances in the rational design and programmed assembly of DNA wireframe polyhedra. Their assembly is based on three distinctively different strategies: individual strands-based assembly, tile-based assembly, and scaffolded DNA origami. Applications of these polyhedral structures in templated nanomaterial assembly and in-vivo cargo delivery are discussed. In the future, expanding the structural complexity and exploring their applications, especially in nanomaterials science and biomedicines, should be a primary focus of this rapidly developing and evolving activity of structural DNA nanotechnology.

show abstract

Sentinel lymph node imaging by a fluorescently labeled DNA tetrahedron

Cited by 66 publications

References 38 publications

Control of polymeric nanoparticle size to improve therapeutic delivery

Control of polymeric nanoparticle size to improve therapeutic delivery

Programmable and Multifunctional DNA‐Based Materials for Biomedical Applications

Supramolecular Wireframe DNA Polyhedra: Assembly and Applications

Contact Info

Product

Resources

About