Sentinel lymph node identification using superparamagnetic iron oxide particles versus radioisotope: The French Sentimag feasibility trial

Houpeau, J.-L.; Chauvet, Marie‐Pierre; Guillemin, François; Bendavid-Athias, Cécile; Charitansky, H.; Kramar, Andrew; Giard, S.

doi:10.1002/jso.24164

Cited by 65 publications

(93 citation statements)

References 38 publications

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“…The noninferiority of SLNB using a magnetic substance and a magnetic probe has been verified in the French Sentimag, Nordic Sentimag trial, Sentimag Multicenter Trial, and Central‐European Sentimag trial, as well as other studies . In those studies, patients received injections of both SPIO and 99m Tc, with or without blue dye.…”

Section: Discussionmentioning

confidence: 87%

Multicenter clinical trial on sentinel lymph node biopsy using superparamagnetic iron oxide nanoparticles and a novel handheld magnetic probe

Taruno

Kurita

Kuwahata

et al. 2019

Journal of Surgical Oncology

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Background Sentinel lymph node biopsy is a standard staging procedure for early axillary lymph node‐negative breast cancer. As an alternative to the currently used radioactive tracers for sentinel lymph node (SLN) detection during the surgical procedure, a number of studies have shown promising results using superparamagnetic iron oxide (SPIO) nanoparticles. Here, we developed a new handheld, cordless, and lightweight magnetic probe for SPIO detection. Methods Resovist (SPIO nanoparticles) were detected by the newly developed handheld probe, and the SLN detection rate was compared to that of the standard radioisotope (RI) method using radioactive colloids (99mTc) and a blue dye (indigo carmine). This was a multicenter prospective clinical trial that included 220 patients with breast cancer scheduled for sentinel node biopsy after a clinical diagnosis of negative axillary lymph node from three facilities in Japan. Results Of the 210 patients analyzed, SLN was detected in 94.8% (199/210 cases, 90% confidence interval [CI]) with our magnetic method and in 98.1% (206/210 cases, 90% CI) with the RI method. The magnetic method exceeded the threshold identification rate of 90%. Conclusion This was the first clinical study to use a novel handheld magnetometer to detect SLN, which we demonstrate to be not inferior to the RI method.

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Section: Discussionmentioning

confidence: 87%

Multicenter clinical trial on sentinel lymph node biopsy using superparamagnetic iron oxide nanoparticles and a novel handheld magnetic probe

Taruno

Kurita

Kuwahata

et al. 2019

Journal of Surgical Oncology

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“…Three more feasibility studies were excluded owing to lack of an appropriate sample size calculation. Seven articles matched the inclusion criteria and were available for meta‐analysis.…”

Section: Resultsmentioning

confidence: 99%

Meta-analysis of sentinel lymph node biopsy in breast cancer using the magnetic technique

Zada

Peek

Ahmed

et al. 2016

Journal of British Surgery

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“…The sentinel node detection rates per patient range from 94.4 to 98% [8,9,10,11,12,13,14]. A recent meta-analysis [14] including 7 non-randomised studies [8,9,10,11,12,13,14]showed that Sienna+ is non-inferior to standard mapping techniques for sentinel node detection.…”

Section: Superparamagnetic Iron Oxidementioning

confidence: 99%

“…A recent meta-analysis [14] including 7 non-randomised studies [8,9,10,11,12,13,14]showed that Sienna+ is non-inferior to standard mapping techniques for sentinel node detection. There was no difference in detection rate per patient (fixed odds ratio (OR) 1.10; 95% confidence interval (CI) 0.67-1.79; p = 0.71) between Sienna+ and the standard tracer technique.…”

Section: Superparamagnetic Iron Oxidementioning

confidence: 99%

New Technologies for Sentinel Lymph Node Detection

Goyal¹

2018

Breast Care

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The ‘standard of care' method for sentinel node mapping is the combination technique using radioisotope and blue dye although some centres use radioisotope or blue dye alone. Radioisotope usage requires licensing, has regulatory issues around handling and disposal of waste, and logistically may be unavailable or difficult to implement in some centres or less developed country. This has led to the development of alternative methods such as superparamagnetic iron oxide (SPIO), fluorescence techniques using indocyanine green (ICG) or fluorescein, computed tomography lymphography, and contrast-enhanced ultrasound scan (CEUS) using microbubbles. The newer techniques will potentially enable a more widespread adoption of this procedure; however, a common barrier for these techniques is the lack of standardisation and no randomised trials to evaluate their effectiveness against the current standard of care. Furthermore, many of these techniques are more costly and may become redundant in node-negative patients with small tumours if ongoing trials show that sentinel node biopsy offers no additional benefit to grey-scale axillary ultrasound. This review discusses the new techniques for sentinel node mapping that have emerged including their pros and cons.

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Sentinel lymph node identification using superparamagnetic iron oxide particles versus radioisotope: The French Sentimag feasibility trial

Abstract: This new magnetic tracer is a feasible method and a promising alternative to the isotope. It could offer benefits for ambulatory surgery or sites without nuclear medicine departments. J. Surg. Oncol. 2016;113:501-507. © 2016 Wiley Periodicals, Inc.

Cited by 65 publications

References 38 publications

Multicenter clinical trial on sentinel lymph node biopsy using superparamagnetic iron oxide nanoparticles and a novel handheld magnetic probe

Multicenter clinical trial on sentinel lymph node biopsy using superparamagnetic iron oxide nanoparticles and a novel handheld magnetic probe

Meta-analysis of sentinel lymph node biopsy in breast cancer using the magnetic technique

New Technologies for Sentinel Lymph Node Detection

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