Sentinel lymph node dissection only versus complete axillary lymph node dissection in early invasive breast cancer: A systematic review and meta-analysis

Axillary lymph node dissection versus sentinel lymph node biopsy alone for early breast cancer with sentinel node metastasis: A meta-analysis

“…However, the result was based on a subgroup analysis of only one RCT, 42 which would lead to potential publication bias. Glechner et al 49 including one RCT and two observational studies showed that the 5-year overall survival rate was higher in ALND than in SLNB alone, but the difference was not statistically significant (Odds ratio [OR] 1.18, 95% CI 0.95e1.47, P ¼ 0.14), with high heterogeneity among studies (I 2 ¼ 78%, P ¼ 0.01) by random effects model. If adopting fixed effects model, the survival rate was significantly different between SLNB alone and ALND in early breast cancer patients (OR 1.20, 95% CI 1.10e1.31, P < 0.01).…”

Comparison of seroma production in breast conserving surgery with or without intraoperative radiotherapy as tumour bed boost

“…Overall 25 % of the breast seromas and 78 % of the axillary seromas required aspiration. Since the publication of the Z0011 study [20] the rates of axillary dissection have further dropped leaving fewer patients with clinical relevant seromas [10], while sentinel node biopsy technique is known to reduce the rate of axillary seroma [21]. Recently Cracco published higher post-operative complication rates after IORT compared to non-IORT [13].…”

Should a Drain Be Placed in Early Breast Cancer Surgery?

“…As the extent of the surgical procedure decreases due to neoadjuvant chemotherapy or as a consequence of studies questioning the current standard [7,44], surgical procedures also need to be adapted. Our study provides an overview of systematic reviews with various aspects of drains and their benefits.…”