Sentinel lymph node biopsy of primary apocrine sweat gland carcinoma of the axilla: A case report and review of the literature

Sekine, Chikako; Kawase, Kazumi; Yoshida, Kazuhiko

doi:10.1016/j.ijscr.2020.10.067

Cited by 4 publications

(2 citation statements)

References 18 publications

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“…Our nding supports a therapeutic effect of LN assessment in providing disease control in more than 80% of CAC patients in clinical local stage. Although the SLNB technique has not been established for CAC, it may be considered as a method for assessing LN metastasis in cases whereby the primary tumor is distant from the regional LNs [2,19,20].…”

Section: Discussionmentioning

confidence: 99%

Prognostic factors in cutaneous apocrine carcinoma: A single-institution retrospective study of 32 patients

Tsuruta¹,

Ogata²,

Namikawa³

et al. 2023

Preprint

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Background Cutaneous apocrine carcinoma (CAC) is a rare adnexal carcinoma. Limited data exists on the demographics and overall survival (OS) of patients with CAC; thus, there is no consensus on surgical management. This study aimed to examine demographic and survival data of patients with CAC to determine optimal surgical management. Methods A single-center retrospective cohort study was conducted at the National Cancer Center Hospital in Tokyo between 2005 and 2022. Patients with a histologically-confirmed CAC diagnosis were identified and data on patient demographics, OS, and lymph node (LN) status were gathered. Results Thirty-two patients were included (median age, 65.5 years; male-female ratio, 15:1). The most common involvement site was the axilla (87.5%). Of the nine patients in the clinical local stage, pathological LN metastases were found in five patients. Either pathological LN or distant metastases were present in 75% of the patients at initial diagnosis. The most common initial surgical treatments included wide local excision and complete LN dissection. Across cohorts, the median OS was 39 months. Patients with ≥ 4 LN metastases had reduced recurrence-free survival and OS compared to those with ≤ 3 LN metastases (p = 0.042, p = 0.041, respectively). The OS was not remarkably different between patients who did and did not receive postoperative radiation therapy. Conclusions Since CAC has a high rate of LN metastasis—and the number of LN metastases is a significant prognostic factor—LN evaluation should be considered for patients with CAC as initial treatment. Nonetheless, ≥ 4 LN metastases can be a poor prognostic factor for CAC.

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Section: Discussionmentioning

confidence: 99%

Prognostic factors in cutaneous apocrine carcinoma: A single-institution retrospective study of 32 patients

Tsuruta¹,

Ogata²,

Namikawa³

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Here, 84% of the patients were assessed for LN metastasis, and 75% of the patients with CAC had LN metastasis or distant metastasis at initial diagnosis. Although the SLNB technique has not been established for CAC, it may be considered as a method for assessing LN metastasis in cases whereby the primary tumor is distant from the regional LNs [2,19,20].…”

Section: Discussionmentioning

confidence: 99%

Prognostic factors in cutaneous apocrine carcinoma: a single-institution retrospective study of 32 patients

Tsuruta,

Ogata,

Namikawa

et al. 2023

Int J Clin Oncol

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BackgroundCutaneous apocrine carcinoma (CAC) is a rare adnexal carcinoma. Limited data exists on the demographics and overall survival (OS) of patients with CAC; thus, there is no consensus on surgical management. This study aimed to examine demographic and survival data of patients with CAC to determine optimal surgical management. MethodsA single-center retrospective cohort study was conducted at the National Cancer Center Hospital in Tokyo between 2005 and 2022. Patients with a histologically-con rmed CAC diagnosis were identi ed and data on patient demographics, OS, and lymph node (LN) status were gathered. ResultsThirty-two patients were included (median age, 65.5 years; male-female ratio, 15:1). The most common involvement site was the axilla (87.5%). Of the nine patients in the clinical local stage, pathological LN metastases were found in ve patients. Either pathological LN or distant metastases were present in 75% of the patients at initial diagnosis. The most common initial surgical treatments included wide local excision and complete LN dissection. Across cohorts, the median OS was 39 months. Patients with ≥ 4 LN metastases had reduced recurrence-free survival and OS compared to those with ≤ 3 LN metastases (p = 0.042, p = 0.041, respectively). The OS was not remarkably different between patients who did and did not receive postoperative radiation therapy. ConclusionsSince CAC has a high rate of LN metastasis-and the number of LN metastases is a signi cant prognostic factor-LN evaluation should be considered for patients with CAC as initial treatment.Nonetheless, ≥ 4 LN metastases can be a poor prognostic factor for CAC.

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Appendageal Tumors

Belfort,

de Gouvea Faiçal,

De Lima

et al. 2023

Oncodermatology

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Sentinel lymph node biopsy of primary apocrine sweat gland carcinoma of the axilla: A case report and review of the literature

Cited by 4 publications

References 18 publications

Prognostic factors in cutaneous apocrine carcinoma: A single-institution retrospective study of 32 patients

Prognostic factors in cutaneous apocrine carcinoma: A single-institution retrospective study of 32 patients

Prognostic factors in cutaneous apocrine carcinoma: a single-institution retrospective study of 32 patients

Appendageal Tumors

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