Sentinel lymph node biopsy in papillary thyroid cancer: Accuracy and application in clinical practice

Rodríguez, Amaia Expósito; Gómez, Igone Corta; Ayala, Maite Domínguez; Carrillo, Maitane García; García, Ana Isabel González; Rodríguez, María Teresa Gutiérrez; Alday, Amelia Oleaga; Fano, Miguel Paja; Iriarte, María Luisa Rodríguez; Olano, Aitziber Ugalde; Landa, Roza Zabala

doi:10.1016/j.cireng.2022.04.022

Cited by 2 publications

(4 citation statements)

References 19 publications

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“…Overall, although large prospective RCT are lacking, data reported in the literature attest that SNM is an effective method for intercepting most clinically occult metastases in approximately 30–40% of cases ( 8 , 10 – 13 , 15 – 17 , 22 , 23 ), both in the central and lateral neck, so that SNM could serve as an objective indicator for RAI or to modulate radioactivity doses, or for therapeutic compartmental dissection. The controversy arises when we look at the clinical usefulness of SNM, since no differences appear in observed relapse rates and disease specific survival when applying SNM, prophylactic dissection, or simple observation ( 26 ).…”

Section: The Methods Of Snm In Thyroid Cancermentioning

confidence: 99%

“…The concept of SNM has been excellently summarized by Dr. Expòsito Rodriguez: sentinel node mapping is the intraoperative complement of a negative US scan ( 8 ). In thyroid cancer, the SNM is a clue to accurate N staging while reducing surgical dissection, associated costs, and morbidity ( 9 ), while SNM has nearly null rates of related complications ( 10 ).…”

Section: The Rationale For Snm In Thyroid Cancermentioning

confidence: 99%

“…In thyroid cancer, the SNM is a clue to accurate N staging while reducing surgical dissection, associated costs, and morbidity ( 9 ), while SNM has nearly null rates of related complications ( 10 ). A positive SNB could guide the extent of surgery, limiting lateral compartmental dissection only for therapeutic purposes ( 10 – 13 ) and personalize postoperative radiometabolic treatment ( 8 , 14 – 17 ). Furthermore, SNM provides the ability to visualize altered lymphatic pathways and individual lymphatic patterns ( 18 ).…”

Section: The Rationale For Snm In Thyroid Cancermentioning

confidence: 99%

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Sentinel node mapping in thyroid cancer: an overview

et al. 2023

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In this paper we describe the current status of sentinel node mapping (SNM) in thyroid tumors and its potential perspectives. SNM in thyroid cancer has been tested since the end of the twentieth century, mainly in papillary thyroid cancer (PTC) and in medullary thyroid cancer (MTC). In PTC, it has been employed to find occult lymph node metastases in the central compartment of the neck as an alternative or indication for prophylactic dissection, by several methods. All of them have proven effective in spotting sentinel nodes, but the results have been somewhat diminished by uncertainty about the clinical significance of occult metastases in differentiated thyroid cancer. SNM in MTC has also been used to find occult lymph node metastases in the lateral compartments of the neck, also with excellent results hindered by a similar doubt about the real clinical significance of MTC micrometastases. Well designed, adequately sized randomized controlled trials are lacking, so SNM in thyroid tumors remains an interesting yet experimental methodology. New technology is emerging that could facilitate such studies, which could add solid information about the clinical significance of occult neck metastases in thyroid cancer.

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Section: The Methods Of Snm In Thyroid Cancermentioning

confidence: 99%

Section: The Rationale For Snm In Thyroid Cancermentioning

confidence: 99%

Section: The Rationale For Snm In Thyroid Cancermentioning

confidence: 99%

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Sentinel node mapping in thyroid cancer: an overview

et al. 2023

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“…In Kim et al ( 71 ) evaluated the utility of lateral neck SLN biopsy in detecting lateral neck node dissection in patients affected by MTC. In Rodriguez et al ( 94 ) published a study on the detection of SLN in 55 PTCs using LS procedure: the SLN detection, the sensitivity and the specificity were 96.36, 86.21 and 100%, respectively. The authors concluded that the results of sensitivity and specificity of SLN procedure are similar in literature even if the variability of the different describing methods limits their interpretation.…”

Section: Application Of Sln In Tcmentioning

confidence: 99%

Sentinel lymph node mapping: current applications and future perspectives in thyroid carcinoma

Boschin,

Bertazza,

Scaroni

et al. 2023

Front. Med.

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Sentinel lymph node (SLN) mapping is a standard, minimally-invasive diagnostic method in the surgical treatment of many solid tumors, as for example melanoma and breast cancer, for detecting the presence of regional nodal metastases. A negative SLN accurately indicates the absence of metastases in the other regional lymph nodes (LN), thus avoiding unnecessary lymph nodal dissection. Papillary thyroid carcinoma (PTC) is the most common type of thyroid carcinoma (TC) with cervical LN metastases at diagnosis in 20–90%, and nodal involvement correlates with local persistence/recurrence. The SLN in PTC is an intraoperative method for staging preoperative N0 patients and for detecting metastatic LNs “in and outside” the cervical LN central compartment; it represents an alternative method to prophylactic central neck node dissection. In this review we summarize different methods and results of the use of SLN in TC. The SLN identification techniques currently used include the selective vital-dye (VD) method, 99mTc-nanocolloid planar lymphoscintigraphy with intraoperative use of a hand-held gamma probe (LS), the combination LS + VD, and the combination LS and preoperative SPECT–CT (LS + SPECT/CT). The application of the SLN procedure in TC has been described in many studies, however, the techniques are heterogeneous, and the role of SLN in TC, with indications, results, advantages and limits, is still debated.

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Sentinel lymph node biopsy in papillary thyroid cancer: Accuracy and application in clinical practice

Cited by 2 publications

References 19 publications

Sentinel node mapping in thyroid cancer: an overview

Sentinel node mapping in thyroid cancer: an overview

Sentinel lymph node mapping: current applications and future perspectives in thyroid carcinoma

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