“…Given the small number of patients, it is unclear whether these findings reflect the higher mean tumor depth 38 or are related to an inverse correlation between positive SLNB and age. 46 In contrast to findings in adults, we observed that a positive SLNB was not associated significantly with additional positive lymph nodes identified at therapeutic lymph node dissection ( 10%) 41,48,50,51 or with a greater risk of death. 37 Similar to other reports, 18 we observed a higher SLNB-positive rate in patients aged 10 years (probably related to greater Breslow thickness), although the prognosis for survival was worse in the older group.…”
BACKGROUND: Cutaneous melanoma in childhood is rare; therefore, its prognostic factors and biologic behavior and the effectiveness of adjuvant diagnostic techniques in this group remain mostly unknown. METHODS: The authors conducted a retrospective, observational study on the prognostic significance of clinical and pathologic findings from 137 cutaneous and mucosal melanomas in patients aged <18 years that were reviewed by the pathology department of a large cancer center during the period from 1992 to 2006. RESULTS: Univariate analysis indicated that there was a significantly greater risk of metastases for patients who had previous nonmelanocytic malignancies, nodular histologic type, fusiform or spitzoid cytology, high Breslow thickness, vertical growth phase, high dermal mitotic activity, ulceration, and vascular invasion. Adjacent nevus and radial growth phase were associated with a better prognosis. Twelve patients (10.3%) died during follow-up. Decreased overall survival was related significantly to age >10 years, previous nonmelanocytic malignancy, high Breslow thickness, high Clark level, and the presence of metastases at diagnosis. All patients who died were aged !11 years, and 8 of those patients had metastases at diagnosis. In multivariate analysis, higher Breslow thickness predicted an increased risk of metastases, whereas age >10 years and the presence of metastases at diagnosis were associated with decreased survival. CONCLUSIONS: Similar to adults, the detection of metastases at diagnosis in children with melanoma was 1 of the main factors that influenced overall survival. Melanomas that were detected in children aged <11 years appeared to have a less aggressive behavior than those detected in adults. Cancer 2010;116:4334-44.
“…Given the small number of patients, it is unclear whether these findings reflect the higher mean tumor depth 38 or are related to an inverse correlation between positive SLNB and age. 46 In contrast to findings in adults, we observed that a positive SLNB was not associated significantly with additional positive lymph nodes identified at therapeutic lymph node dissection ( 10%) 41,48,50,51 or with a greater risk of death. 37 Similar to other reports, 18 we observed a higher SLNB-positive rate in patients aged 10 years (probably related to greater Breslow thickness), although the prognosis for survival was worse in the older group.…”
BACKGROUND: Cutaneous melanoma in childhood is rare; therefore, its prognostic factors and biologic behavior and the effectiveness of adjuvant diagnostic techniques in this group remain mostly unknown. METHODS: The authors conducted a retrospective, observational study on the prognostic significance of clinical and pathologic findings from 137 cutaneous and mucosal melanomas in patients aged <18 years that were reviewed by the pathology department of a large cancer center during the period from 1992 to 2006. RESULTS: Univariate analysis indicated that there was a significantly greater risk of metastases for patients who had previous nonmelanocytic malignancies, nodular histologic type, fusiform or spitzoid cytology, high Breslow thickness, vertical growth phase, high dermal mitotic activity, ulceration, and vascular invasion. Adjacent nevus and radial growth phase were associated with a better prognosis. Twelve patients (10.3%) died during follow-up. Decreased overall survival was related significantly to age >10 years, previous nonmelanocytic malignancy, high Breslow thickness, high Clark level, and the presence of metastases at diagnosis. All patients who died were aged !11 years, and 8 of those patients had metastases at diagnosis. In multivariate analysis, higher Breslow thickness predicted an increased risk of metastases, whereas age >10 years and the presence of metastases at diagnosis were associated with decreased survival. CONCLUSIONS: Similar to adults, the detection of metastases at diagnosis in children with melanoma was 1 of the main factors that influenced overall survival. Melanomas that were detected in children aged <11 years appeared to have a less aggressive behavior than those detected in adults. Cancer 2010;116:4334-44.
“…Over the last 5 years, the technical feasibility of SLNBX for pediatric melanoma has been demonstrated [3][4][5][6]. As described in these earlier series and in our current report, SLNBX can be performed with a high success rate and a very low incidence of complications.…”
Section: Discussionsupporting
confidence: 67%
“…Mean Breslow depth of all lesions was 3.2 F 1.0 mm (SEM). Twenty regional lymph node basins were sampled and at least 1 sentinel lymph node was identified in all 20 patients with a mean of 1.9 nodes removed per patient (range, [1][2][3][4][5]. A focus of metastatic disease was identified in the sentinel lymph nodes of 5 of 15 patients with a preoperative diagnosis of melanoma and 3 of 5 patients with melanocytic lesions of unknown biologic significance (total, 40%).…”
Section: Resultsmentioning
confidence: 99%
“…SLNBX for children with melanoma has increased over the last 5 years [3][4][5][6]. However, the role of this procedure in the staging of pediatric melanoma remains to be defined as long-term follow-up data are currently unavailable [7,8].…”
“…Overall, 25.6% of patients undergoing SLNB had LNM in our study, and this figure is similar to prior published data [5,6,33,37,41,42]. Though the incidence of LNM is Journal of Surgical Oncology known to be higher in children, children with LNM have a lower incidence of recurrence and improved disease-free survival compared to adults [5,32,43].…”
SLNB use for children with melanoma was associated with clinicopathologic, socioeconomic, and hospital factors. Younger patients have a higher likelihood of LNM but are the least likely to undergo SLNB. Though overall adherence appears high, there remains an opportunity for improved care for children with melanoma.
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