Sentinel lymph node biopsy in patients with thick (= 4 mm) melanoma: a single‐centre experience

Cecchi, Roberto; Buralli, Lauro; Innocenti, Stefania; Seghieri, Giuseppe; Gaudio, C. De

doi:10.1111/j.1468-3083.2006.02072.x

Cited by 23 publications

(21 citation statements)

References 15 publications

(36 reference statements)

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“…In accordance with several other studies focusing on this particular subgroup (table 4), our data clearly confirmed SLNB to be a highly significant prognostic parameter even in high-risk melanoma >4.0 mm [6,7,12,20,21,22,23,24,25,26,27,28]. Despite a relatively low percentage of 29.9% SLN positivity in our cohort, SLN status proved to be highly predictive of a worse prognosis on both RFS as well as OS in uni- and multivariate Cox regression.…”

Section: Discussionsupporting

confidence: 79%

“…Only the cohorts studied by Cecchi et al [24] and Jacobs et al [21] achieved significant results with smaller cohorts of 30–43 patients. Clearly, only larger collectives with a longer follow-up time succeeded in confirming a significantly impaired RFS and OS for SLN status [7,20,23,25].…”

Section: Discussionmentioning

confidence: 99%

“…Nonetheless studies that focused on T4 melanoma did not yield unequivocal results with respect to the prognostic value of SLN status or other risk factors [6,7,12,20,21,22,23,24,25,26,27]. …”

Section: Discussionmentioning

confidence: 99%

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Sentinel Lymph Node Biopsy Status Is a Key Parameter to Stratify the Prognostic Heterogeneity of Malignant Melanoma in High-Risk Tumors >4.0 mm

Göppner¹,

Ulrich

Pokrywka³

et al. 2010

Dermatology

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Background: The value of sentinel lymph node biopsy (SLNB) as a useful strategy to assess the risk of future metastasis in high-risk melanomas (>4.0 mm) is controversially discussed. Objectives: In a single-center retrospective study, the prognostic relevance of SLNB and other risk factors in the subgroup of melanomas >4.0 mm was investigated and compared to previously published results. Methods: Using Kaplan-Meier estimates and Cox regressions, we assessed the prognostic relevance of SLNB in our subcohort of 87 patients with thick melanomas >4.0 mm (T4). The mean follow-up for this subgroup was 51 months. We compared SLN value as compared to ulceration. Results: SLN and ulceration, analyzed as separate risk factors as well as their combination, predicted a highly reduced life expectancy in terms of recurrence-free survival (RFS) in our cohort of patients. SLN, but not ulceration, also predicted overall survival (OS). Conclusions: Positive SLNB is an essential predictor of RFS and OS in T4 melanoma patients, whereas ulceration lacked significance with respect to OS in our cohort. Our data thus suggest the routine use of SLNB also for T4 melanoma and may therefore allow to optimize risk-stratified therapeutic regimens.

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

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Sentinel Lymph Node Biopsy Status Is a Key Parameter to Stratify the Prognostic Heterogeneity of Malignant Melanoma in High-Risk Tumors >4.0 mm

Göppner¹,

Ulrich

Pokrywka³

et al. 2010

Dermatology

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“…This stratification may create some concerns when comparing different studies. We should point out that several authors [4][5][6][7][8][9][10][11][12] stated that sentinel lymph node status predicts DFS as well as OS in patients with thick melanoma.…”

Section: Discussionmentioning

confidence: 99%

“…Fairbairn et al achieved similar results in their study. 3 Several other authors [4][5][6][7][8][9][10][11][12] have been successful in correlating the SNB--based staging with improved DFS and OS, advocating its use in this subset of patients. The results presented by Vermeeren et al 13 suggest that the only relevant prognostic factor regarding patients with thick melanoma is SNB and this procedure can be used to stratify patients according to the risk of recurrence.…”

Section: Introductionmentioning

confidence: 99%

Biópsia do Gânglio Sentinela em Melanomas Espessos: Estudo Clínico Retrospectivo num Único Centro

Lemos

Vieira

Brinca

et al. 2016

SPDV

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RESUMO -Introdução:A biopsia do gânglio sentinela é um procedimento genericamente aceite no estdiamento do melanoma. O valor prognóstico desta técnica parece ser mais relevante nos melanomas de espessura intermédia (1-4mm) do que nos melanomas espessos (>4mm). Objectivo: Avaliar o valor prognóstico do estado do gânglio sentinela em doentes com melanoma espesso. Doentes e Métodos: A sobrevivência livre de doença e a sobrevivência global foram estimadas pelo método de Kaplan-Meier e por um modelo de regressão de Cox numa amostra de doentes com melanoma espesso. Resultados: Foram incluídos 43 doentes (52.2% do sexo masculino) com uma média etária de 63,9 anos. A biopsia do gânglio sentinela foi positiva em 20 casos (46,5%). O tempo médio de seguimento foi de 40 meses. Os doentes em que não foram encontradas metástases no gânglio sentinela tiveram uma sobrevivência livre de doença aos 5 anos significativamente maior do que o grupo de doentes com gânglio sentinela positivo (63% versus 19%, p<0.05). A sobrevivência global aos 5 anos foi tendencialmente mais baixa em doentes com gânglio sentinela positivo (52% versus 79%), embora sem significado estatístico. Conclusão: O estado do gânglio sentinela não teve influência estatística na sobrevivência global dos doentes da nossa série de melanomas espessos, provavelmente devido ao risco elevado de metastização por via hemática. Porém, a biopsia do gânglio sentinela forneceu informação prognóstica relevante, uma vez que teve clara influência na sobrevivência livre de doença. PALAVRAS-CHAVE -Biópsia do Gânglio Sentinela; Melanoma; Neoplasias da Pele; Prognóstico; Taxa de Sobrevida. Sentinel Lymph Node Biopsy in Thick Melanoma

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Head and Neck Melanoma

Andrews¹,

Myers²

2011

Head and Neck Cancer

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Sentinel lymph node biopsy in patients with thick (= 4 mm) melanoma: a single‐centre experience

Abstract: Our retrospective analysis indicates that the SLN status is predictive of recurrence and survival in patients with thick melanoma, and LM/SLNB should be routinely performed in this subset of melanoma patients.

Cited by 23 publications

References 15 publications

Sentinel Lymph Node Biopsy Status Is a Key Parameter to Stratify the Prognostic Heterogeneity of Malignant Melanoma in High-Risk Tumors >4.0 mm

Sentinel Lymph Node Biopsy Status Is a Key Parameter to Stratify the Prognostic Heterogeneity of Malignant Melanoma in High-Risk Tumors >4.0 mm

Biópsia do Gânglio Sentinela em Melanomas Espessos: Estudo Clínico Retrospectivo num Único Centro

Head and Neck Melanoma

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