Sentinel lymph node biopsy in high-risk endometrial cancer: performance, outcomes, and future avenues

Kim, Yoo-Na; Kim, Young Tae

doi:10.5468/ogs.22146

Cited by 5 publications

(5 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For high-risk patients, SLNB had acceptable diagnostic accuracy and can guide adjuvant chemotherapy and radiotherapy [ 42 , 43 ]. It is suggested that SLNB combined with ProMisE classification in the high-risk group needs more data to support [ 44 ]. Furthermore, attention should be paid to preoperative evaluation for suspicious positive lymph nodes or extrauterine invasion and metastasis as complementary to SLNB in high risk group [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

Metabolic syndrome score as an indicator in a predictive nomogram for lymph node metastasis in endometrial cancer

Feng

Yang

et al. 2023

BMC Cancer

View full text Add to dashboard Cite

Background Lymph node metastasis (LNM) is an important factor affecting endometrial cancer (EC) prognosis. Current controversy exists as to how to accurately assess the risk of lymphatic metastasis. Metabolic syndrome has been considered a risk factor for endometrial cancer, yet its effect on LNM remains elusive. We developed a nomogram integrating metabolic syndrome indicators with other crucial variables to predict lymph node metastasis in endometrial cancer. Methods This study is based on patients diagnosed with EC in Peking University People’s Hospital between January 2004 and December 2020. A total of 1076 patients diagnosed with EC and who underwent staging surgery were divided into training and validation cohorts according to the ratio of 2:1. Univariate and multivariate logistic regression analyses were used to determine the significant predictive factors. Results The prediction nomogram included MSR, positive peritoneal cytology, lymph vascular space invasion, endometrioid histological type, tumor size > = 2 cm, myometrial invasion > = 50%, cervical stromal invasion, and tumor grade. In the training group, the area under the curve (AUC) of the nomogram and Mayo criteria were 0.85 (95% CI: 0.81–0.90) and 0.77 (95% CI: 0.77–0.83), respectively (P < 0.01). In the validation group (N = 359), the AUC was 0.87 (95% CI: 0.82–0.93) and 0.80 (95% CI: 0.74–0.87) for the nomogram and the Mayo criteria, respectively (P = 0.01). Calibration plots revealed the satisfactory performance of the nomogram. Decision curve analysis showed a positive net benefit of this nomogram, which indicated clinical value. Conclusion This model may promote risk stratification and individualized treatment, thus improving the prognosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Metabolic syndrome score as an indicator in a predictive nomogram for lymph node metastasis in endometrial cancer

Feng

Yang

et al. 2023

BMC Cancer

View full text Add to dashboard Cite

show abstract

“…Moreover, in the RS group, para-aortic lymph node dissection or sentinel lymph node sampling, which is important for staging, was performed more frequently than that in the LS group. This could be due to the Firefly technology of the robotic system ( 19 , 20 ).…”

Section: Discussionmentioning

confidence: 99%

Robot-assisted versus conventional laparoscopic surgery for endometrial cancer: long-term comparison of outcomes

Eoh,

Kim,

Park

et al. 2023

Front. Oncol.

Self Cite

View full text Add to dashboard Cite

ObjectiveThere is a lack of multi-institutional large-volume and long-term follow-up data on comparisons between robot-assisted surgery and conventional laparoscopic surgery. This study compared the surgical and long-term survival outcomes between patients who underwent robot-assisted or conventional laparoscopic surgery for endometrial cancer.MethodsWe retrospectively reviewed the data of patients from five large academic institutions who underwent either robot-assisted or conventional laparoscopic surgery for the treatment of endometrial cancer between 2012 and 2017, ensuring at least 5 years of potential follow-up. Intra- and postoperative outcomes, long-term disease-free survival, and overall survival were compared.ResultsThe study cohort included 1,003 unselected patients: 551 and 452 patients received conventional laparoscopic and robot-assisted surgery, respectively. The median follow-up duration was 57 months. Postoperative complications were significantly less likely to occur in the robot-assisted surgery group compared to the laparoscopic surgery group (7.74% vs. 13.79%, P = 0.002), primarily limited to minor complications. There were no significant differences in survival: 5-year disease-free survival was 91.2% versus 90.0% (P = 0.628) and overall survival was 97.9% versus 96.8% (P = 0.285) in the robot-assisted and laparoscopic surgery cohorts, respectively. Cox proportional hazard regression models demonstrated that the mode of surgery was not associated with disease-free survival (hazard ratio, 0.897; confidence interval, 0.563–1.429) or overall survival (hazard ratio, 0.791; confidence interval, 0.330–1.895) after adjusting for confounding factors.ConclusionRobot-assisted surgery for endometrial cancer demonstrates comparable long-term survival outcomes and a reduced incidence of postoperative minor complications when compared to conventional laparoscopic surgery.

show abstract

“…Vaginal cuff dehiscence was defined as a full-thickness opening of the anterior and posterior edges of the vaginal cuff without protruding bowel. The surgical procedures performed, including open and laparoscopic hysterectomies, followed previously described techniques [15][16][17][18][19][20]. To ensure that only patients who developed vaginal cuff dehiscence as a complication of hysterectomy were included in the study (as shown in Figure 2), the medical records of patients who developed dehiscence were thoroughly reviewed.…”

Section: Methodsmentioning

confidence: 99%

“…Vaginal cuff dehiscence was defined as a fullthickness opening of the anterior and posterior edges of the vaginal cuff without protruding bowel. The surgical procedures performed, including open and laparoscopic hysterectomies, followed previously described techniques [15][16][17][18][19][20]. Surgical techniques for hysterectomy vary widely and can impact the incidence of vaginal cuff dehiscence.…”

Section: Methodsmentioning

confidence: 99%

Clinical Relevance of Vaginal Cuff Dehiscence after Minimally Invasive versus Open Hysterectomy

Eoh

Lee

Nam

et al. 2023

JCM

Self Cite

View full text Add to dashboard Cite

This study aimed to evaluate the clinical relevance of vaginal cuff dehiscence following a hysterectomy. Data were prospectively collected from all patients who underwent hysterectomies at a tertiary academic medical center between 2014 and 2018. The incidence and clinical factors of vaginal cuff dehiscence after minimally invasive versus open hysterectomy were compared. Vaginal cuff dehiscence occurred in 1.0% (95% confidence interval [95% CI], 0.7–1.3%) of women who underwent either form of hysterectomy. Among those who underwent open (n = 1458), laparoscopic (n = 3191), and robot-assisted (n = 423) hysterectomies, vaginal cuff dehiscence occurred in 15 (1.0%), 33 (1.0%), and 3 (0.7%) cases, respectively. No significant differences in cuff dehiscence occurrence were identified in patients who underwent various modes of hysterectomies. A multivariate logistic regression model was created using the variables indication for surgery and body mass index. Both variables were identified as independent risk factors for vaginal cuff dehiscence (odds ratio [OR]: 2.74; 95% CI, 1.51–4.98 and OR: 2.20; 95% CI, 1.09–4.41, respectively). The incidence of vaginal cuff dehiscence was exceedingly low in patients who underwent various modes of hysterectomies. The risk of cuff dehiscence was predominantly influenced by surgical indications and obesity. Thus, the different modes of hysterectomy do not influence the risk of vaginal cuff dehiscence.

show abstract

Sentinel lymph node biopsy in high-risk endometrial cancer: performance, outcomes, and future avenues

Cited by 5 publications

References 64 publications

Metabolic syndrome score as an indicator in a predictive nomogram for lymph node metastasis in endometrial cancer

Metabolic syndrome score as an indicator in a predictive nomogram for lymph node metastasis in endometrial cancer

Robot-assisted versus conventional laparoscopic surgery for endometrial cancer: long-term comparison of outcomes

Clinical Relevance of Vaginal Cuff Dehiscence after Minimally Invasive versus Open Hysterectomy

Contact Info

Product

Resources

About