Sentinel Lymph Node Biopsy in Patients with Breast Cancer

Cox, Charles E.; Cox, John M.; Mariani, Giuliano; Wilkie, Caren E.G.; White, Laura; Khera, Samira Y.; Hasson, Danielle M.

doi:10.1007/978-0-387-38327-9_9

Cited by 2 publications

(2 citation statements)

References 80 publications

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“…In breast cancer, once the learning phase of SLNB has been completed, the success rate of lymphoscintigraphy and intraoperative gamma probe counting in identifying SLNs is higher than 96-97% in experienced centers. This value is greater than that commonly experienced using blue dye alone (75-80%), while combining radioguidance with the blue dye leads to a 98-99% success rate in SLN identification [33]. The blue dye can be injected around the primary tumor or scar (in a similar way as the radiocolloid was injected) 10-20 min prior to the operation.…”

Section: Key Learning Pointsmentioning

confidence: 92%

General Concepts on Radioguided Sentinel Lymph Node Biopsy: Preoperative Imaging, Intraoperative Gamma Probe Guidance, Intraoperative Imaging, Multimodality Imaging

Orsini¹,

Guidoccio²,

Vidal-Sicart³

et al. 2020

Atlas of Lymphoscintigraphy and Sentinel Node Mapping

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Section: Key Learning Pointsmentioning

confidence: 92%

General Concepts on Radioguided Sentinel Lymph Node Biopsy: Preoperative Imaging, Intraoperative Gamma Probe Guidance, Intraoperative Imaging, Multimodality Imaging

Orsini¹,

Guidoccio²,

Vidal-Sicart³

et al. 2020

Atlas of Lymphoscintigraphy and Sentinel Node Mapping

Self Cite

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“…Dedicated scintimammography has provided very encouraging results in terms of sensitivity and specificity [9,14]. In addition, it is considered as a very useful tool for optimized biopsy, since radioguided biopsy highlights the most active hot spots in the suspicious tumors and minimizes needle mispositioning [15,16].…”

Section: Introductionmentioning

confidence: 99%

Experimental and simulation studies for the optimization of dedicated scintimammography cameras

et al. 2012

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The main drawback of scintimammography with conventional gamma cameras is the large distance between detector and breast, which limits imaging performance and adds significant background noise from the heart and other organs. These limitations can be minimized by dedicated gamma cameras placed in tight contact with the breast. The purpose of this study was to determine the lowest Tumor-to-Background (T:B) ratio for detectable lesions and the smallest lesions that can be imaged with a dedicated system. The system is based on an R3292 position sensitive photomultiplier tube (PSPMT) from Hamamatsu, coupled to a 10 cm in diameter CsI(Tl) crystal and a general purpose collimator with hexagonal holes. Two crystals were assessed, with pixel size of 2 × 2 mm 2 and 3 × 3 mm 2 . The experimental setup consists of a cylindrical breast phantom, cylindrical tumor phantoms positioned inside the breast phantom at various depths, and a heart phantom. The same setup, as well as some additional tumor phantoms, were modeled with the GATE simulation toolkit, following the validation of the entire system. A 20% energy window and the Dual Energy Window Subtraction Method (DEWSM) for scatter correction were applied in experimental and simulation data. In all measurements 99m Tc was used. Signal to Noise Ratio (SNR) and contrast were measured in all experiments and used for quantification of results. Experimental and simulation results show that the lowest T:B ratio that can be detected is 2:1 with tumor phantom volume ≥ 0.25 ml at 1 cm depth. The smallest volume of a tumor phantom that can be detected is 0.04 ml with T:B ratio equal to 9:1 at 1 cm depth.

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Sentinel Lymph Node Biopsy in Patients with Breast Cancer

Cited by 2 publications

References 80 publications

General Concepts on Radioguided Sentinel Lymph Node Biopsy: Preoperative Imaging, Intraoperative Gamma Probe Guidance, Intraoperative Imaging, Multimodality Imaging

General Concepts on Radioguided Sentinel Lymph Node Biopsy: Preoperative Imaging, Intraoperative Gamma Probe Guidance, Intraoperative Imaging, Multimodality Imaging

Experimental and simulation studies for the optimization of dedicated scintimammography cameras

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