Sentinel Lymph Node Biopsy in Recessive Dystrophic Epidermolysis Bullosa and Squamous Cell Carcinoma

Perez-Naranjo, Lara; Herrera-Saval, A.; García-Bravo, Begoñá; Pérez-Bernal, Ana; Camacho, Francisco

doi:10.1001/archderm.141.1.110

Cited by 24 publications

(17 citation statements)

References 4 publications

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“…The procedure led to negative results in all cases. The outcome of these patients was not specified except for one, who was still alive 12 months after the procedure [8, 9, 25, 26]. …”

Section: Resultsmentioning

confidence: 99%

Inherited epidermolysis bullosa and squamous cell carcinoma: a systematic review of 117 cases

Montaudié¹,

Chiavérini²,

Sbidian

et al. 2016

Orphanet J Rare Dis

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Background: Inherited epidermolysis bullosa (EB) comprises a highly heterogeneous group of rare diseases characterized by exacerbated skin and/or mucosal fragility and blister formation after minor mechanical trauma. Level of cleavage in the skin, clinical features with immunofluorescence antigen mapping and/or electron microscopy examination of a skin biopsy and/or gene involved, type(s) of mutation present and sometimes specific mutation(s), allow to define the EB type and subtype. This family of genodermatoses exposes patients to several complications, cutaneous squamous cell carcinoma (cSCC) being the most severe of them. Objective: The aim of this systematic review was to document patients with EB who developed cSCC.

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“…The procedure led to negative results in all cases. The outcome of these patients was not specified except for one, who was still alive 12 months after the procedure [8, 9, 25, 26]. …”

Section: Resultsmentioning

confidence: 99%

Inherited epidermolysis bullosa and squamous cell carcinoma: a systematic review of 117 cases

Montaudié¹,

Chiavérini²,

Sbidian

et al. 2016

Orphanet J Rare Dis

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“…A review of the literature identified a total of 161 worldwide patients in 14 case series including this study [9,10,20-30], and 5 case reports [31-35] describing the use of SLN biopsy in patients with cutaneous SCC. Three case series [27-29] and one case report [31] were excluded since these patients were later combined into larger institutional case series resulting in a total of 130 evaluable cases (Table 2).…”

Section: Resultsmentioning

confidence: 99%

Sentinel lymph node biopsy for high-risk cutaneous squamous cell carcinoma: clinical experience and review of literature

2011

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High-risk cutaneous squamous cell carcinoma (SCC) is associated with an increased risk of metastases. The role of sentinel lymph node (SLN) biopsy in these patients remains unclear. To address this uncertainty, we collected clinical data on six patients with clinical N0 high-risk SCC that underwent SLN biopsy between 1999 and 2006 and performed a literature review of SLN procedures for SCC to study the utility of SLN biopsy. There were no positive SLN identified among six cases and there was one local and one distant recurrence on follow-up. Literature review identified 130 reported cases of SLN biopsy for SCC. The SLN positivity rate was 14.1%, 10.1%, and 18.6%; false negative rate was 15.4%, 0%, and 22.2%; and the negative predictive value was 97.8%, 100%, and 95.2% for all sites, head/neck, and truncal/extremity sites, respectively. SLN biopsy remains an investigational staging tool in clinically node-negative high-risk SCC patients. The higher false negative rate and lower negative predictive value among SCC of the trunk/extremity compared to SCC of the head/neck sites suggests a more cautious approach when treating patients with the former. Given the paucity of long-term follow up, an emphasis is placed upon the need for close surveillance regardless of SLN status.

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“…The role of sentinel node biopsy in EB patients is still unclear. 46,47 If necessary, further tumor staging should be performed.…”

Section: Discussionmentioning

confidence: 99%

Risk of squamous cell carcinoma in junctional epidermolysis bullosa, non-Herlitz type: Report of 7 cases and a review of the literature

Yuen

Jonkman

2011

Journal of the American Academy of Dermatology

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Sentinel Lymph Node Biopsy in Recessive Dystrophic Epidermolysis Bullosa and Squamous Cell Carcinoma

Cited by 24 publications

References 4 publications

Inherited epidermolysis bullosa and squamous cell carcinoma: a systematic review of 117 cases

Inherited epidermolysis bullosa and squamous cell carcinoma: a systematic review of 117 cases

Sentinel lymph node biopsy for high-risk cutaneous squamous cell carcinoma: clinical experience and review of literature

Risk of squamous cell carcinoma in junctional epidermolysis bullosa, non-Herlitz type: Report of 7 cases and a review of the literature

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