Sentinel lymph node biopsy in endometrial and cervical cancers using freehand SPECT—first experiences

Markus, Alexander R.; Ray, Alessandra Sophia Carmen; Bolla, Daniele; Müller, Joachim; Diener, Pierre‐André; Wendler, Thomas; Hornung, René

doi:10.1007/s10397-016-0969-x

Cited by 10 publications

(4 citation statements)

References 25 publications

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“…Unfortunately, radiation dose to the patient does increase. fhSPECT navigation + Ultrasound (Percutaneous interventions) 100,113,114,116,119,120,130,150,156,157,179,[186][187][188]191,[194][195][196]198,199,212,216,220,221,244,245,254] Radioguided occult lesion localization (ROLL) Pulmonary lesions (e.g. lung cancer), thyroid cancer, endometriosis, renal cancer, ovary cancer, colorectal In the evolution of surgical techniques, more and more minimally invasive alternatives are being pursued, of which (robot-assisted) laparoscopic surgery is a prime example [112].…”

Section: Article Highlightsmentioning

confidence: 99%

“…Since the clinical introduction in 2010, fhSPECT has shown to be useful for several nuclear detection modalities, including open surgery γ probes [187][188][189], open surgery portable γ cameras [156,186,190], laparoscopic γ probes [179,191,192] and even the recently introduced DROP-IN γ probe [193]. As a result, this technology has already been evaluated during many different radioguided surgery procedures, such as SN in breast cancer [156,182,187], RSL in breast cancer [189], SN in head and neck cancers [186,188,[194][195][196][197], SN in melanoma [186,198,199], SN in prostate cancer [179], SN in penile cancer [179], SN in gynecology [191], ROLL for pulmonary lesions [192], PSMA-targeted prostate salvage procedures [108], parathyroid adenoma [178], NET tumors [200] and various bone lesions [201].…”

Section: Background and Recent Advances Using A Surgicalmentioning

confidence: 99%

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Recent advances in nuclear and hybrid detection modalities for image-guided surgery

Oosterom

Rietbergen

Welling

et al. 2019

Expert Review of Medical Devices

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Introduction: Radioguided surgery is an ever-evolving part of nuclear medicine. In fact, this nuclear medicine sub-discipline actively bridges non-invasive molecular imaging with surgical care. Next to relying on the availability of radio-and bimodal-tracers, the success of radioguided surgery is for a large part dependent on the imaging modalities and imaging concepts available for the surgical setting. With this review, we have aimed to provide a comprehensive update of the most recent advances in the field. Areas covered: We have made an attempt to cover all aspects of radioguided surgery: 1) the use of radioisotopes that emit γ, β + , and/or β − radiation, 2) hardware developments ranging from probes to 2D cameras and even the use of advanced 3D interventional imaging solutions, and 3) multiplexing solutions such as dual-isotope detection or combined radionuclear and optical detection. Expert opinion: Technical refinements in the field of radioguided surgery should continue to focus on supporting its implementation in the increasingly complex minimally invasive surgical setting, e.g. by accommodating robot-assisted laparoscopic surgery. In addition, hybrid concepts that integrate the use of radioisotopes with other image-guided surgery modalities such as fluorescence or ultrasound are likely to expand in the future.

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Section: Article Highlightsmentioning

confidence: 99%

Section: Background and Recent Advances Using A Surgicalmentioning

confidence: 99%

Recent advances in nuclear and hybrid detection modalities for image-guided surgery

Oosterom

Rietbergen

Welling

et al. 2019

Expert Review of Medical Devices

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“…With the increasing use of the hybrid tracer ICG-99m Tc-nanocolloid during SN procedures, the proposed hybrid image-guided surgery approach should be directly implementable in a broad range of indications: prostate cancer [62], penile cancer [63], breast cancer [22], various head and neck cancers [11], [23] and cervical cancer [21]. While the currently proposed fhFluo system is only applicable during open surgery procedures, the recently introduced laparoscopic opto-nuclear probe [28] indicates a translation towards laparoscopic procedures as well, similar as laparoscopic freehand SPECT [36], [64], [65]. In addition, radioguided surgery is also increasingly finding its way into receptor targeted tumor resections, such as the targeting of somatostatin [66] and prostate specific membrane antigen [1] positive tumors.…”

Section: Discussionmentioning

confidence: 99%

Extending the Hybrid Surgical Guidance Concept With Freehand Fluorescence Tomography

Oosterom

Poel

Leeuwen

et al. 2020

IEEE Trans. Med. Imaging

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Within image-guided surgery, 'hybrid' guidance technologies have been used to integrate the complementary features of radioactive guidance and fluorescence guidance. Here, we explore how the generation of a novel freehand fluorescence (fhFluo) imaging approach complements freehand SPECT (fhSPECT) in a hybrid setup. Near-infrared optical tracking was used to register the position and the orientation of a hybrid opto-nuclear detection probe while recording its readings. Dedicated look-up table models were used for 3D reconstruction. In phantom and excised tissue settings (i.e., flat-surface human skin explants), fhSPECT and fhFluo were investigated for image resolution and in-tissue signal penetration. Finally, the combined potential of these freehand technologies was evaluated on prostate and lymph node specimens of prostate cancer patients receiving prostatectomy and sentinel lymph node dissection (tracers: indocyanine green (ICG) + 99m Tc-nanocolloid or ICG-99m Tc-nanocolloid). After hardware and software integration, the hybrid setup created 3D nuclear and fluorescence tomography scans. The imaging Manuscript

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“…Preclinical research has also been performed to investigate freehand imaging of beta emissions [ 95 , 118 ], high-energy gamma emissions [ 119 ], or even freehand PET imaging using a coincidence or time-of-flight principle with multiple detectors [ 120 , 121 ]. While freehand SPECT is mainly used for open surgery procedures (e.g., SLNB or even receptor-targeted procedures [ 18 ]), this technology has also been translated to laparoscopic procedures, e.g., SLNB in gynecology and urology [ 77 , 122 ] as well as radio-guided occult lesion localization in the lung [ 123 ]. However, the laparoscopic setting application is more challenging, where the limited movement of a laparoscopic probe restricts signal acquisition, and with that, reduces the quality of the freehand SPECT scan.…”

Section: Intraoperative Planning Decision and Excision Assistancementioning

confidence: 99%

How molecular imaging will enable robotic precision surgery

Wendler

Leeuwen

Navab

et al. 2021

Eur J Nucl Med Mol Imaging

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Molecular imaging is one of the pillars of precision surgery. Its applications range from early diagnostics to therapy planning, execution, and the accurate assessment of outcomes. In particular, molecular imaging solutions are in high demand in minimally invasive surgical strategies, such as the substantially increasing field of robotic surgery. This review aims at connecting the molecular imaging and nuclear medicine community to the rapidly expanding armory of surgical medical devices. Such devices entail technologies ranging from artificial intelligence and computer-aided visualization technologies (software) to innovative molecular imaging modalities and surgical navigation (hardware). We discuss technologies based on their role at different steps of the surgical workflow, i.e., from surgical decision and planning, over to target localization and excision guidance, all the way to (back table) surgical verification. This provides a glimpse of how innovations from the technology fields can realize an exciting future for the molecular imaging and surgery communities.

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Sentinel lymph node biopsy in endometrial and cervical cancers using freehand SPECT—first experiences

Cited by 10 publications

References 25 publications

Recent advances in nuclear and hybrid detection modalities for image-guided surgery

Recent advances in nuclear and hybrid detection modalities for image-guided surgery

Extending the Hybrid Surgical Guidance Concept With Freehand Fluorescence Tomography

How molecular imaging will enable robotic precision surgery

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