Sentinel lymph node biopsy for early stage tongue cancer—a 14-year single-centre experience

Hingsammer, Lukas; Seier, Thomas; Zweifel, Daniel; Huber, Gerhard; Rücker, Martin; Bredell, Marius; Lanzer, Martin

doi:10.1016/j.ijom.2018.10.011

Cited by 14 publications

(15 citation statements)

References 29 publications

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“…Furthermore, although it failed to reach statistical significance, our data support previously published trends towards a poorer overall, disease-free and disease-specific survival (OS, DFS and DSS, respectively) in SLNB +patients compared to those without disease. 5,29,30 These observations support the feasibility and utility of pathology centralisation in SLNB in OSCC. As SLNB becomes more widely available, more pathology hubs will be required to avoid overreliance on existing centralised services.…”

Section: Discussionsupporting

confidence: 59%

Centralised pathology service for sentinel node biopsy in oral cavity cancer: The Southeast England Consortium experience

Patel

Bowe

Garg

et al. 2022

J Oral Pathology Medicine

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Background Sentinel lymph node biopsy is an increasingly recognised option for accurate staging and subsequent management of the clinically negative neck in early stage oral cavity squamous cell carcinoma. However, the technique is currently underused due to several logistic constraints including increased burden on pathology services. Here, we describe the feasibility of an outsourced centralised pathology processing and reporting service for sentinel lymph node biopsies in oral cavity squamous cell carcinoma. Patients and methods The Southeast England Consortium comprises four surgical centres utilising a central pathology service. Consecutive cases between January 2016 and February 2020 were retrospectively evaluated for survival outcomes and laboratory turnaround times. Results Twenty‐eight per cent from a cohort of 139 patients had positive sentinel nodes. There was a trend towards greater overall, disease‐free and disease‐specific survival (OS, DFS and DSS, respectively) in sentinel node negative compared to sentinel node positive patients, but these differences were not statistically significant. The sensitivity, negative predictive value and false negative rate were 92.8%, 97.0% and 6.8%, respectively. The mean and mode laboratory TAT were 5 and 4 working days, respectively. Conclusion An outsourced centralised pathology service is a feasible option to widen the availability of sentinel node biopsy in oral cavity squamous cell carcinoma.

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Section: Discussionsupporting

confidence: 59%

Centralised pathology service for sentinel node biopsy in oral cavity cancer: The Southeast England Consortium experience

Patel

Bowe

Garg

et al. 2022

J Oral Pathology Medicine

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“…Two authors individually collected data from included articles in forms commensurate with each other. Diagnostic accuracy, represented by DOR, summary receiver operating characteristic (SROC) curve, and area under the curve (AUC), was calculated 1,5,11–102 . DOR was calculated as (true positive [TP]/false positive [FP])/(false negative [FN]/true negative [TN]) to assess diagnostic accuracy with 95% confidence intervals (CIs).…”

Section: Methodsmentioning

confidence: 99%

Usefulness of Sentinel Lymph Node Biopsy for Oral Cancer: A Systematic Review and Meta‐Analysis

Kim

et al. 2020

The Laryngoscope

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Objective We assessed the diagnostic accuracy of sentinel lymph node biopsy (SLNB) for detecting neck nodal metastasis in early oral squamous cell carcinoma (OSCC) as an alternative to elective neck dissection. Study Design A systematic search for relevant literature was conducted in the PubMed, SCOPUS, Embase, Web of Science, and Cochrane databases. Methods Two reviewers individually searched the five databases up to November 2019. For studies that met inclusion criteria, data on patient diagnoses were pooled, including true positives, true negatives, false positives, and false negatives. Methodological quality was checked with the Quality Assessment of Diagnostic Accuracy Studies (version 2) tool. Results In total, 98 observational or retrospective studies were included. The diagnostic odds ratio of SLNB was 326.165 (95% confidence interval [CI]: 231.477–459.587; I2 = 0%). The area under the summary receiver operating characteristic curve was 0.982. Sensitivity was 0.827 (95% CI: 0.804–0.848), and specificity was 0.981 (95% CI: 0.975–0.986). The correlation between sensitivity and the false positive rate was −0.076, which indicates that heterogeneity did not exist. Subgroup analyses were performed with the subgroups reference test type, publication year, and study type. No significant difference was found within the reference test type subgroup. However, differences within the publication year and study type subgroups were significant, where the retrospective study subgroup was significantly more sensitive and specific than the prospective study subgroup. Conclusion Results of this meta‐analysis imply that the high specificity of SLNB supports its role as a diagnostic tool for patients with clinical tumor stage (CT)1‐2 clinically negative (N0) OSCC. More studies should be done to further verify the results of this study. Level of Evidence 2a Laryngoscope, 131:E459–E465, 2021

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“…In our study the prevalence of occult lymph node metastases consisting of both patients with invaded SLN (n = 8) and patients with later cervical lymph node metastases (considered as false negative SLNB, n = 2) was 14%, which is slightly lower than that reported by other groups (20%-30%). 2,4,5 Previous studies of SLNB at our hospital reported occult metastases in 27% of patients during 2000-2001 19 and 22% during 2002-2005. 20 Two patients had recurrence of cervical lymph nodes, both of whom had clear SLNB and neither had local recurrence.…”

Section: Discussionmentioning

confidence: 87%

“…[1][2][3] Regardless of current advanced imaging techniques, occult metastases are detected in up to 20%-30% of T1-T2N0 oral carcinomas. 2,4,5 Improved imaging techniques with contrastenhanced computed tomography (CT) scans and magnetic resonance imaging (MRI) have been noted to increase the rate of detection of lymph node metastases. 6 The current accepted practice is to do an elective neck dissection (END) when the risk of nodal metastasis is estimated to exceed 20%.…”

Section: Introductionmentioning

confidence: 99%

Sentinel lymph node biopsies in early stage oral and oropharyngeal carcinoma: a retrospective single-centre experience

Marttila

Keski-Säntti

Hagström

et al. 2020

British Journal of Oral and Maxillofacial Surgery

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Sentinel lymph node biopsy for early stage tongue cancer—a 14-year single-centre experience

Cited by 14 publications

References 29 publications

Centralised pathology service for sentinel node biopsy in oral cavity cancer: The Southeast England Consortium experience

Centralised pathology service for sentinel node biopsy in oral cavity cancer: The Southeast England Consortium experience

Usefulness of Sentinel Lymph Node Biopsy for Oral Cancer: A Systematic Review and Meta‐Analysis

Sentinel lymph node biopsies in early stage oral and oropharyngeal carcinoma: a retrospective single-centre experience

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