Sentinel Lymph Node Biopsy and Complete Lymph Node Dissection for Melanoma

Delgado, Anna Falk; Zommorodi, Sayid

doi:10.1007/s11912-019-0798-y

Cited by 37 publications

(28 citation statements)

References 71 publications

(59 reference statements)

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“…Treatment methods ranked second among the results. Terms associated with surgical methods including “Exeresis” and “Mohs surgery” refer to effective treatment modalities for early-stage noninvasive melanoma and therefore attract public interest ( 65 , 66 ). Consistent with the bibliometric analysis, immunotherapies and risk genes attracted attention.…”

Section: Discussionmentioning

confidence: 99%

Research Interest and Public Interest in Melanoma: A Bibliometric and Google Trends Analysis

et al. 2021

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IntroductionMelanoma is a severe skin cancer that metastasizes quickly. Bibliometric analysis can quantify hotspots of research interest. Google Trends can provide information to address public concerns.MethodsThe top 15 most frequently cited articles on melanoma each year from 2015 to 2019, according to annual citations, were retrieved from the Web of Science database. Original articles, reviews, and research letters were included in this research. For the Google Trends analysis, the topic “Melanoma” was selected as the keyword. Online search data from 2004 to 2019 were collected. Four countries (New Zealand, Australia, the United States and the United Kingdom) were selected for seasonal analysis. Annual trends in relative search volume and seasonal variation were analyzed, and the top related topics and rising related topics were also selected and analyzed.ResultsThe top 15 most frequently cited articles each year were all original articles that focused on immunotherapy (n=8), omics (n=5), and the microbiome (n=2). The average relative search volume remained relatively stable across the years. The seasonal variation analysis revealed that the peak appeared in summer, and the valley appeared in winter. The diseases associated with or manifestations of melanoma, treatment options, risk factors, diagnostic tools, and prognosis were the topics in which the public was most interested. Most of the topics revealed by bibliometric and Google Trends analyses were consistent, with the exception of issues related to the molecular biology of melanoma.ConclusionThis study revealed the trends in research interest and public interest in melanoma, which may pave the way for further research.

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Section: Discussionmentioning

confidence: 99%

Research Interest and Public Interest in Melanoma: A Bibliometric and Google Trends Analysis

et al. 2021

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“…Surgery is the first option at early stages of melanoma and can be considered curative for melanoma in situ [1,28]. Depending on disease stage, a more extensive surgical procedure may be considered [29][30][31][32]. Another therapeutic modality is radiotherapy, which is often used as a palliative option at advanced stages or when surgery is contraindicated [1].…”

Section: Melanoma-therapeutic Managementmentioning

confidence: 99%

The Challenging Melanoma Landscape: From Early Drug Discovery to Clinical Approval

Matias

Pinho

Penetra

et al. 2021

Cells

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Melanoma is recognized as the most dangerous type of skin cancer, with high mortality and resistance to currently used treatments. To overcome the limitations of the available therapeutic options, the discovery and development of new, more effective, and safer therapies is required. In this review, the different research steps involved in the process of antimelanoma drug evaluation and selection are explored, including information regarding in silico, in vitro, and in vivo experiments, as well as clinical trial phases. Details are given about the most used cell lines and assays to perform both two- and three-dimensional in vitro screening of drug candidates towards melanoma. For in vivo studies, murine models are, undoubtedly, the most widely used for assessing the therapeutic potential of new compounds and to study the underlying mechanisms of action. Here, the main melanoma murine models are described as well as other animal species. A section is dedicated to ongoing clinical studies, demonstrating the wide interest and successful efforts devoted to melanoma therapy, in particular at advanced stages of the disease, and a final section includes some considerations regarding approval for marketing by regulatory agencies. Overall, considerable commitment is being directed to the continuous development of optimized experimental models, important for the understanding of melanoma biology and for the evaluation and validation of novel therapeutic strategies.

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“…Лечение местнораспространенной меланомы с метастатическими поражениями лимфатических узлов включает в себя резекцию первичного очага с отрицательным краем резекции и регионарными лимфатическими узлами. Лимфаденэктомия выполняется при наличии пальпируемых узлов при физикальном осмотре или у пациентов с положительной биопсией сторожевого узла [3]. При меланоме кожи нижних конечностей открытая паховая лимфаденэктомия является стандартной операцией при метастатическом поражении регионарных лимфатических узлов.…”

Section: оригинальные исследования введениеunclassified

Efficacy of Videoendoscopic Inguinal Femoral Lymphadenectomy for Management of Metastatic Skin Melanoma

Egorenkov¹,

Моисеенко²,

Volkov³

et al. 2021

Kreativnaâ hirurgiâ i onkologiâ

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Aim. Assessment of the utility and advantage of videoendoscopic inguinal femoral lymphadenectomy (VE-LAD) over the standard open technique (OLAD) in patients with malignant skin melanoma and metastatic lesions of regional inguinal and/or femoral lymph nodes.Materials and methods. The Saint-Petersburg Clinical Research Centre for Specialty Medical Aid in Oncology managed 86 inguinal femoral LADs in melanoma patients over 2013–2016. VE-LAD was rendered in 48 (54.7 %) cases, and OLAD otherwise.Results and discussion. A total of 72 patients were included in the study. VE-LAD was performed in 48 (54.7 %) cases, and OLAD otherwise. An average VE-LAD duration was 90 (60 to 160) min. Severe complications were observed in 4/48 (8 %) VE-LAD and 16/24 (66 %) OLAD cases, which reveals a significantly lower complication rate in the study cohort (chi-square p > 0.000). Lymphorrhoea was shorter in the study cohort (> 7 days in 5 patients vs. 3/24 and > 14 days only in 11/24 OLAD cases; chi-square p > 0.000). No significant differences in relapse-free survival were observed between the cohorts, with higher absolute values of 22.6 months in the VE-LAD (95 % CI 14.8–30.4, p = 0.087) vs. 9.4 months (95 % CI 0.0–18.9, p = 0.087) in OLAD cohort. A median OS was 52.3 months (95 % CI 30.5–74.1, p = 0.996) in the VE-LAD vs. 39.9 months (95 % CI 30.6–49.2, p = 0.996) in OLAD cohort.Conclusion. Videoendoscopic inguinal femoral lymphadenectomy allows a radical inguinal femoral lymph node removal alike in conventional surgical dissection. Our results indicate the method performance towards reduced postoperative wound complications. The oncological indicators are comparable to the traditional surgery cohort.

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Sentinel Lymph Node Biopsy and Complete Lymph Node Dissection for Melanoma

Cited by 37 publications

References 71 publications

Research Interest and Public Interest in Melanoma: A Bibliometric and Google Trends Analysis

Research Interest and Public Interest in Melanoma: A Bibliometric and Google Trends Analysis

The Challenging Melanoma Landscape: From Early Drug Discovery to Clinical Approval

Efficacy of Videoendoscopic Inguinal Femoral Lymphadenectomy for Management of Metastatic Skin Melanoma

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