Sentinel Coronavirus environmental monitoring can contribute to detecting asymptomatic SARS-CoV-2 virus spreaders and can verify effectiveness of workplace COVID-19 controls

Marshall, Douglas L.; Jensen, Søren Krogh; Linde, Svend Aage; Higby, Richard; Rémy-McCort, Yvoine; Murray, Séan; Dieckelman, Bryan; Sudradjat, Fitri; Martin, Gilles G.

doi:10.1016/j.mran.2020.100137

Cited by 30 publications

(40 citation statements)

References 18 publications

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“…This study showed that there are associations between positive SARS-CoV-2 antibody results and high-risk behavior such as traveling, use of public transportation, contact with symptomatic patients, and working at high-risk places (like hospital staff, taxi drivers, and working in crowded places like peddlers). This finding is consistent with the study that showed there is a relation between the diagnosis of asymptomatic COVID-19 infected people and viruscontaminated environments (21). So continuous monitoring, restriction of the passage of people in crowded areas, and disinfecting environments with risk of contamination along with mass vaccination in a short period of time can be useful in decreasing patients and prevention of disease spread.…”

Section: Discussionsupporting

confidence: 91%

SARS-CoV-2 seroprevalence in asymptomatic or mild symptomatic people and symptomatic patients with negative PCR results: The hidden perspective in epidemiological reports

Hajiahmadi

mojtahedzade

Yari

et al. 2021

Preprint

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Background: SARS-CoV-2 has led to the current pandemic of respiratory disease. The reports of confirmed COVID-19 cases based on molecular tests do not completely cover the total number of infected people. These reports do not include the asymptomatic or mildly symptomatic patients and also the patients with false-negative RT-PCR results, while the infection is contagious in all of these conditions. Objective: In this study, we tried to improve our conception of the hidden perspective of SARS-CoV-2 in epidemiological reports. Methods: From May 30 to June 17, 2020, blood samples were collected from two groups of people: asymptomatic or mild symptomatic volunteer participants and severe symptomatic hospitalized patients with negative PCR results. Detection of SARS-CoV-2 antibody was done with ELISA kit targeting N or S proteins. Results: Totally 716 samples from volunteer participants and 81 samples from symptomatic hospitalized patients with negative PCR were evaluated. The test performance-adjusted seroprevalence (95% CI) of SARS-CoV-2 anti-N IgG was 17.3% (8.8%, 25.8%) for volunteers and 25.5% (12.8%, 39.7%) for anti-N and S IgM in hospitalized group. There was an association between high-risk occupations, high-risk behaviors, or symptomatic diseases with positive SARA-Cov-2 N antibody results. Among anti-N positive infected individuals, 49.2% (21.4%, 78.8%) were anti-S positive. Conclusion: The results showed that SARS-COV-2 infection occurs in asymptomatic or mildly symptomatic individuals, but in more than half of them, the produced antibody is not protective. Findings of hospitalized patients also showed that the combination of IgM assay with real-time PCR improves the detection of the disease by more than 25% in negative molecular cases.

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Section: Discussionsupporting

confidence: 91%

SARS-CoV-2 seroprevalence in asymptomatic or mild symptomatic people and symptomatic patients with negative PCR results: The hidden perspective in epidemiological reports

Hajiahmadi

mojtahedzade

Yari

et al. 2021

Preprint

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“…SARS-CoV-2 RNA can be detected from many different kinds of surfaces, places, and devices, including phones ( Marshall et al, 2020 ; Santarpia et al, 2020 ; Ye et al, 2020 ; Zhou et al, 2020 ). Furthermore, active SARS-CoV-2 virus is more likely to be recovered from some surfaces when expelled from individuals with seemingly high viral load ( Bullard et al, 2020 ; Jefferson et al, 2020 ; Sonnleitner et al, 2021 ).…”

Section: Resultsmentioning

confidence: 99%

Smartphone screen testing, a novel pre-diagnostic method to identify SARS-CoV-2 infectious individuals

Young

Solis²,

Barriga-Fehrman³

et al. 2021

eLife

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The COVID-19 pandemic will likely take years to control globally, and constant epidemic surveillance will be required to limit the spread of SARS-CoV-2, especially considering the emergence of new variants that could hamper the effect of vaccination efforts. We developed a simple and robust - Phone Screen Testing (PoST) - method to detect positive SARS-CoV-2 individuals by RT-PCR testing of smartphone screen swab samples. We show that 81.3-100% of individuals with high-viral load SARS-CoV-2 nasopharyngeal positive samples also test positive for PoST, suggesting this method is effective in identifying COVID-19 contagious individuals. Furthermore, we successfully identified polymorphisms associated with SARS-CoV-2 Alpha, Beta and Gamma variants, in SARS-CoV-2 positive PoST samples. Overall, we report that PoST is a new non-invasive, cost-effective, and easy to implement smartphone-based smart alternative for SARS-CoV-2 testing, which could help to contain COVID-19 outbreaks and identification of variants of concern in the years to come.

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“…Behavior changes in the form of implementing health protocols as a general rule can prevent transmission if there is no medical intervention yet (West et al, 2020). In addition to adjusting the criteria for IHC, it is also necessary to carry out health protocols in the office (Marshall et al, 2020), as described as follows; basic hygiene routines, frequent disinfection, fitness screening, social distancing, workplace flexibility, and reducing face to face meetings. Several health protocols have been implemented to help reduce biological pollutants in IHC 5 criteria through the application of basic hygiene routines by creating a habit of washing hands, providing soap and running water at several spots in the workplace, particularly in the area before the entrance (Figure 6).…”

Section: Ihc 10mentioning

confidence: 99%

Adaptation of Indoor Health and Comfort Criteria to Mitigate Covid-19 Transmission in the Workplace

Wardhani

Susan

2021

Humaniora

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The research discussed the application of indoor health and comfort criteria that needed to be reviewed to create good indoor environmental quality and reduce the transmission of the Covid-19 virus where people spent most of their time indoors. A confined area, which was poorly ventilated and reliant on air conditioning, helped transmit the Covid-19 virus easily as air recirculation was the main cause of office clusters. One of the categories of Greenship Interior Space, Indoor Health and Comfort (IHC), could be used as a guide for creating better indoor quality. The method used for the research was a systematic literature review to define, study, analyze, and classify all available research relating to adaptation of indoor health and comfort criteria to mitigate the transmission in the workplace. The results show the adjustment to IHC criteria in IHC 1-10, which focus on providing good air quality by introducing outside air, stopping air recirculation, reducing indoor user capacity, and reducing indoor biological and chemical pollutants. To illustrate the implementation of the new normal, Ciputra University workplace was being observed, as the findings of the results, some strategies that are in line with the objectives of IHC 1, IHC 2, and IHC 5. Adjustment of these criteria must be supported by implementing health protocols through basic hygiene routines, fitness screening, and maintaining physical distancing.

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Sentinel Coronavirus environmental monitoring can contribute to detecting asymptomatic SARS-CoV-2 virus spreaders and can verify effectiveness of workplace COVID-19 controls

Cited by 30 publications

References 18 publications

SARS-CoV-2 seroprevalence in asymptomatic or mild symptomatic people and symptomatic patients with negative PCR results: The hidden perspective in epidemiological reports

SARS-CoV-2 seroprevalence in asymptomatic or mild symptomatic people and symptomatic patients with negative PCR results: The hidden perspective in epidemiological reports

Smartphone screen testing, a novel pre-diagnostic method to identify SARS-CoV-2 infectious individuals

Adaptation of Indoor Health and Comfort Criteria to Mitigate Covid-19 Transmission in the Workplace

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