Sentinel animals for monitoring the environmental lead exposure: combination of traditional review and visualization analysis

Chen, Xing; Cao, Suzhen; Wen, Dongsen; Geng, Yishuo; Duan, Xiaoli

doi:10.1007/s10653-022-01241-9

Cited by 5 publications

(2 citation statements)

References 190 publications

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“…Lead (Pb), cadmium (Cd), arsenic (As), and mercury (Hg) are all heavy metals/metalloids with adverse health effects, and their latency period is also shorter in pets compared to humans [ 41 ]. The absorption, metabolization, transformations, and toxicity of these substances in pets is the most similar to that of young children, which makes companion animals even more valuable in early detection [ 42 ]. In a 2005 study, Park et al [ 43 ] concludes that dogs can be considered biomonitors of the environmental quality assessment for cadmium, lead, and chromium contamination, and at least for lead and cadmium cats showed the same conclusive results ( Table 2 ).…”

Section: Pets As Sentinels For Environmental Pollutionmentioning

confidence: 99%

Pets, Genuine Tools of Environmental Pollutant Detection

Hegedus,

Andronie,

Uiuiu

et al. 2023

Animals

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In a shared environment, our companion animals became unintended sentinels for pollutant exposure consequences, developing even earlier similar conditions to humans. This review focused on the human–pet cohabitation in an environment we all share. Alongside other species, canine and feline companions are veritable models in human medical research. The latency period for showing chronic exposure effects to pollutants is just a few years in them, compared to considerably more, decades in humans. Comparing the serum values of people and their companion animals can, for example, indicate the degree of poisonous lead load we are exposed to and of other substances as well. We can find 2.4 times higher perfluorochemicals from stain- and grease-proof coatings in canine companions, 23 times higher values of flame retardants in cats, and 5 times more mercury compared to the average levels tested in humans. All these represent early warning signals. Taking these into account, together with the animal welfare orientation of today’s society, finding non-invasive methods to detect the degree of environmental pollution in our animals becomes paramount, alongside the need to raise awareness of the risks carried by certain chemicals we knowingly use.

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Section: Pets As Sentinels For Environmental Pollutionmentioning

confidence: 99%

Pets, Genuine Tools of Environmental Pollutant Detection

Hegedus,

Andronie,

Uiuiu

et al. 2023

Animals

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“…As companion animals, dogs inhabit the same environment as humans and are exposed to the same carcinogenic factors [ 1 , 2 ]. In fact, environmental toxins, old age, and obesity are common carcinogenic factors in both humans and dogs [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Isorhamnetin Regulates Programmed Death Ligand-1 Expression by Suppressing the EGFR–STAT3 Signaling Pathway in Canine Mammary Tumors

Mei,

Zhang,

Zhi

et al. 2024

IJMS

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Programmed death ligand-1 (PD-L1) is highly expressed in a variety of cancer cells and suggests a poorer prognosis for patients. The natural compound isorhamnetin (ISO) shows promise in treating cancers and causing damage to canine mammary tumor (CMT) cells. We investigated the mechanism of ISO in reducing PD-L1 expression in CMT cells. Clustered, regularly interspaced short palindromic repeat-associated protein 9 (CRISPR/Cas9) was used to mediate CD274 knockout in U27 cells. Then, monoclonal cells were screened and cultured. Nucleotide sequencing and expression of PD-L1 were detected. Additionally, we examined cell migration, invasion, and damage. Immunofluorescent staining of PD-L1 was examined in U27 cells. The signaling pathways were measured by Western blotting. Murine xenotransplantation models and murine immunocompetent allograft mammary tumor models were established to evaluate the effect of ISO therapy. Expression of Ki-67, caspase3, and PD-L1 were analyzed by immunohistochemistry. A pull-down assay was used to explore which proteins could bind to ISO. Canine EGFR protein was purified and used to detect whether it directly binds to ISO using a surface plasmon resonance assay. ISO inhibited the EGFR-STAT3-PD-L1 signaling pathway and blocked cancer growth, significantly increasing the survival rate of healthy cells. The cell membrane receptor EGFR was identified as a direct target of ISO. ISO could be exploited as an antineoplastic treatment of CMT by targeting EGFR to suppress PD-L1 expression.

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