Sentence matching is crucial to many natural language processing (NLP) tasks. Generally, the degree of matching is measured from either of the two perspectives: topic-based match or semantic-based match. The former is to investigate if two sentences discuss the same topic, and the latter performs a deep level semantic matching of texts, which is currently the highlight in research. Deep semantic matching requires adequate modeling from the internal structure of the language objects as well as their interactions. To achieve this goal, this paper proposes a multiple-perspective semantics-crossover (MPSC) model for modeling the semantic-based match of two sentences. The model extracts the matching information of two sentences from the semantic interaction information generated from different angles, so as to calculate the matching degree of the two sentences. The MPSC model not only captures rich matching patterns at different levels but also acquires interactive features from different semantic angles. It can be used to address some important issues in NLP fields, such as information matching in text retrieval, question-answer matching in the Q&A system, and so on. The experimental results show that our proposed model of MPSC has better effectiveness than some popular semantic matching approaches.INDEX TERMS Natural language processing, neural networks, semantics matching, text analysis.