Sentence comprehension in Parkinson's disease: The role of attention and memory

Grossman, Murray; Carvell, Susan; Stern, Matthew B.; Gollomp, Stephen; Hurtig, Howard I.

doi:10.1016/0093-934x(92)90074-o

Cited by 182 publications

(117 citation statements)

References 64 publications

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“…However, other primary deficits in the understanding of the grammatical features of a sentence might as well contribute to comprehension deficits, these ones related to frontal dysfunction 27 .…”

Section: Discussionmentioning

confidence: 99%

Contribution to the evaluation of language disturbances in subcortical lesions: a piloty study

Radanovic

Azambuja

Porto

et al. 2004

Arq. Neuro-Psiquiatr.

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-Subcortical structures are in a strategic functional position within the cognitive networks and their lesion can interfere with a great number of functions. In this study, we describe fourteen subjects with exclusively subcortical vascular lesions (eight in the basal ganglia and six in the thalamus) and the interrelation between their language alterations and other cognitive abilities, as attention, memory and frontal executive functions. All patients were evaluated through the following batteries: Boston Diagnostic Aphasia Examination, Boston Naming Test, Token Test, Benton Visual Retention Test, Trail Making, Wisconsin Card Sorting Test and a frontal scripts task. All patients underwent MRI and twelve underwent SPECT. Results show that these patients present impairment in several cognitive domains, especially attention and executive functions. These alterations affect language abilities, and this fact must be considered in the rehabilitation efforts.KEY WORDS: thalamus, basal ganglia, language, frontal dysfunction. Contribuição à avaliação dos distúrbios de linguagem em lesões subcorticais: estudo pilotoRESUMO -As estruturas subcorticais ocupam posição funcional estratégica nas redes cognitivas e sua lesão pode interferir com um grande número de funções. Neste estudo, descrevemos 14 indivíduos com lesões vasculares exclusivamente subcorticais (oito em núcleos da base e seis no tálamo) e a interrelação entre suas alterações de linguagem e de outras funções cognitivas, como atenção, memória e funções executivas. Todos os pacientes foram avaliados através dos seguintes testes: Teste de Boston para Diagnóstico da Afasia, Teste de Nomeação Boston, Teste Token, Teste Benton de Retenção Visual, Trail Making, Wisconsin Card Sorting Test e uma tarefa de scripts frontais. Todos os pacientes realizaram RM de crânio e doze realizaram SPECT. Os resultados mostram que estes pacientes apresentam prejuízo nas várias funções cognitivas, especialmente atenção e funções executivas. Estas alterações afetam as habilidades lingüísticas e devem ser levadas em consideração nos esforços de reabilitação. PALAVRAS-CHAVE: tálamo, núcleos da base, linguagem, alteração frontal.

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Section: Discussionmentioning

confidence: 99%

Contribution to the evaluation of language disturbances in subcortical lesions: a piloty study

Radanovic

Azambuja

Porto

et al. 2004

Arq. Neuro-Psiquiatr.

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“…Three general cognitive processes have been implicated in syntactic comprehension of sentences: (1) regulation of attention, (2) working memory and (3) speed of information processing. Several authors investigated syntactic complexity (e.g., subject-object relative clauses) during sentence comprehension in basal ganglia patients (e.g., Grossman et al, 1991Grossman et al, , 1992Grossman et al, , 1993Lieberman et al, 1990Lieberman et al, , 1992Natsopoulos et al, 1993;Pickett et al, 1998). While Grossman et al (1993) initially argued that syntactic comprehension deficits result from attentional rather than syntactic deficits, Lieberman et al (1990; proposed that repeated errors on syntactically complex sentences cannot be attributed to an attention deficit, but to a working memory deficit.…”

Section: Introductionmentioning

confidence: 99%

Syntactic language processing: ERP lesion data on the role of the basal ganglia

Kotz

Frisch

Cramon

et al. 2003

J Int Neuropsychol Soc

127

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The role of the basal ganglia in syntactic language processing was investigated with event-related brain potentials in fourteen neurologically impaired patients. Seven of these patients had basal ganglia lesions while 7 other patients primarily had lesions of the left temporo-parietal region excluding the basal ganglia. All patients listened to sentences that were either correct or included a verb argument structure violation. In previous experiments this type of violation elicited a biphasic pattern of an N400-P600 complex in young healthy participants. While the N400 may result from incorrect semantic-thematic role assignment, the P600 reflects the fact that verb information does not license the syntactic structure at present. Results of the patient experiment revealed a double dissociation: patients with left temporo-parietal lesions only show a P600, whereas patients with lesions of the basal ganglia showed no P600, but a negativity with extended duration that resembled an N400. The latter pattern not only confirms previous reports that the basal ganglia modulate the P600 but extends these results by showing that the N400 as a late semantic-thematic integration process appears partially modulated by the basal ganglia.

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“…Whereas Ullman, Corkin, et al (1997) held the view that this system's function together with left frontal cortex is the procedural grammar, Grossman and colleagues (Grossman et al, 1991;Grossman, Carvell, Stern, Gollomp, & Hurtig, 1992) considered the system's major function to relate to attentional factors. Friederici et al (1999), in contrast, proposed a possible dissociation between the function of the subcortical structures (i.e., basal ganglia on the one hand and the cortical structures on the other, with the latter supporting procedural syntactic aspects in particular).…”

Section: Patients With Focal Basal Ganglia Lesionsmentioning

confidence: 99%

“…M. Lieberman (2000) attributed this impairment to an inability to decode finer temporal suprasegmental structure in the auditory input. Those studies examining syntactic comprehension reported that PD patients consistently experience comprehension difficulties when faced with syntactically complex sentences (Grossman et al, 1991(Grossman et al, , 1992Natsopoulos et al, 1993). With respect to these patients' grammatical processing deficit, Grossman et al (1993) suggested that it depends on a deficient attentional system rather than the grammar as such.…”

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confidence: 99%

Syntactic comprehension in Parkinson's disease: Investigating early automatic and late integrational processes using event-related brain potentials.

et al. 2003

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Parkinson's disease (PD) has been associated with a general impairment of procedures and with an impairment of syntactic procedures in particular. The present study investigated comprehension processes in PD using event-related brain potentials (ERPs). PD patients and controls listened to sentences that were either correct or syntactically or semantically incorrect. The language-related ERP component correlated with semantic processes (N400) was present in both groups. In the syntactic domain, early automatic processes (early negativity) appeared normal in PD, whereas late integrational processes (P600) were modulated by this disease. The present findings suggest that the basal ganglia primarily do not support early automatic syntactic processes during comprehension but rather support processes of syntactic integration.

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Sentence comprehension in Parkinson's disease: The role of attention and memory

Cited by 182 publications

References 64 publications

Contribution to the evaluation of language disturbances in subcortical lesions: a piloty study

Contribution to the evaluation of language disturbances in subcortical lesions: a piloty study

Syntactic language processing: ERP lesion data on the role of the basal ganglia

Syntactic comprehension in Parkinson's disease: Investigating early automatic and late integrational processes using event-related brain potentials.

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