Sentence comprehension and praxis deficits in Parkinson's disease

Grossman, Murray; Carvell, Susan; Gollomp, Stephen; Stern, Matthew B.; Vernon, Gwyn M.; Hurtig, Howard I.

doi:10.1212/wnl.41.10.1620

Cited by 106 publications

(21 citation statements)

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“…In movement disorders a valid assessment is difficult since praxis deficits are superimposed on elementary motor dysfunctions like bradykinesia (Zadikoff and Lang 2005; Vanbellingen et al 2012). In PD, 17–64 % of the patients exhibit apraxic symptoms (Grossman et al 1991; Leiguarda et al 1997; Vanbellingen et al 2012). This variability in prevalence figures can most likely be attributed to variable apraxia assessments and patients investigated at different disease stages.…”

Section: Introductionmentioning

confidence: 99%

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Early dysfunctions of fronto-parietal praxis networks in Parkinson’s disease

Matt

Foki

Fischmeister

et al. 2016

Brain Imaging and Behavior

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In Parkinson’s disease (PD) the prevalence of apraxia increases with disease severity implying that patients in early stages may already have subclinical deficits. The aim of this exploratory fMRI study was to investigate if subclinical aberrations of the praxis network are already present in patients with early PD. In previous functional imaging literature only data on basal motor functions in PD exists. Thirteen patients with mild parkinsonian symptoms and without clinically diagnosed apraxia and 14 healthy controls entered this study. During fMRI participants performed a pantomime task in which they imitated the use of visually presented objects. Patients were measured ON and OFF dopaminergic therapy to evaluate a potential medication effect on praxis abilities and related brain functions. Although none of the patients was apraxic according to De Renzi ideomotor scores (range 62–72), patients OFF showed significantly lower praxis scores than controls. Patients exhibited significant hyperactivation in left fronto-parietal core areas of the praxis network. Frontal activations were clearly dominant in patients and were correlated with lower individual praxis scores. We conclude that early PD patients already show characteristic signs of praxis network dysfunctions and rely on specific hyperactivations to avoid clinically evident apraxic symptoms. Subclinical apraxic deficits were shown to correlate with an activation shift from left parietal to left frontal areas implying a prospective individual imaging marker for incipient apraxia.

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Section: Introductionmentioning

confidence: 99%

“…The latter study also report that apraxic deficits do not improve with dopaminergic treatment. Importantly, apraxia scores in PD are not correlated with motor disabilities (Goldenberg et al 1986; Grossman et al 1991; Leiguarda et al 1997; Vanbellingen et al 2012). …”

Section: Introductionmentioning

confidence: 99%

Early dysfunctions of fronto-parietal praxis networks in Parkinson’s disease

Matt

Foki

Fischmeister

et al. 2016

Brain Imaging and Behavior

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“…This work showed significantly impaired processing of resource-demanding sentences that stress working memory (Grossman, et al, 1991; Grossman, et al, 1992), as well as difficulty understanding grammatically complex sentences in the setting of increased resource demands such as speeded presentation (C. Lee, et al, 2003) or concomitant performance of a secondary task (Grossman, et al, 2000). This pattern of difficulty was equally evident in an on-line study of sentence processing (Grossman, et al, 2002), emphasizing that these findings could not be easily attributed to task-related demands.…”

Section: Discussionmentioning

confidence: 92%

“…This work has demonstrated sentence processing difficulty in LBSD using a variety of techniques. In the earliest of these studies, probes of sentences varying in grammatical complexity and length revealed a significant sentence processing deficit that was attributed to working memory limitations (Grossman, et al, 1991; Grossman, Carvell, Stern, Gollomp, & Hurtig, 1992). Reduced comprehension of lengthy, grammatically complex sentences was demonstrated as resource demands increased, such as performing a secondary task concurrently (Grossman, Kalmanson, Bernhardt, Stern, & Hurtig, 2000) or increasing sentence presentation speed (C.…”

Section: Introductionmentioning

confidence: 99%

Sentence processing in Lewy body spectrum disorder: The role of working memory

Gross

McMillan

Chandrasekaran

et al. 2012

Brain and Cognition

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Prior work has related sentence processing to executive deficits in non-demented patients with Parkinson’s disease (PD). We extended this investigation to patients with dementia with Lewy bodies (DLB) and PD dementia (PDD) by examining grammatical and working memory components of sentence processing in the full range of patients with Lewy body spectrum disorder (LBSD). Thirty-three patients with LBSD were given a two-alternative, forced-choice sentence-picture matching task. Sentence type, working memory, and grammatical structure were systematically manipulated in the sentences. We found that patients with PDD and DLB were significantly impaired relative to non-demented PD patients and healthy controls. The deficit in PDD/DLB was most pronounced for sentences lengthened by the strategic placement of an additional prepositional phrase and for sentences with an additional proposition due to a center-embedded clause. However, there was no effect for subject-relative versus object-relative grammatical structure. An MRI voxel-based morphometry analysis in a subset of patients showed significant gray matter thinning in the frontal lobe bilaterally, and this extended to temporal, parietal and occipital regions. A regression analysis related sentence processing difficulty in LBSD to frontal neocortex, including inferiorprefrontal, premotor, and dorsolateral prefrontal regions, as well as right superior temporal cortex. These findings are consistent with the hypothesis that patients with PDD and DLB have difficulty processing sentences with increased working memory demands and that this deficit is related in part to their frontal disease.

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“…IMA and LKA are frequently seen in atypical parkinsonisms, such as progressive supranuclear palsy (PSP), dementia with Lewy Bodies (DLB) and as a hallmark in corticobasal degeneration (CBD) [2]. Mild IMA may even occur in some patients with Parkinson’s disease (PD) [3,4,5,6,7] and LKA may be more common than previously thought [8,9,10]. …”

Section: Introductionmentioning

confidence: 99%

Short and valid assessment of apraxia in Parkinson’s disease

Vanbellingen¹,

Lungu²,

Lopez³

et al. 2012

Parkinsonism & Related Disorders

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Background Valid assessment of apraxia in usually non-apraxic Parkinson’s disease helps to delineate atypical parkinsonism frequently associated with apraxia. Furthermore, in a subgroup of late Parkinson’s disease apraxia, typically the ideomotor subtype, may gradually superimpose onto parkinsonian motor symptoms contributing to defective manual skill. Here we evaluate the utility of a brief, standardized test, the apraxia screen of TULIA (AST). Methods Seventy five Parkinson’s disease patients were tested with the AST. Parkinsonian motor deficits were measured using Movement Disorders Society-Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) part III and difficulties in activities of daily living (ADL) by modified MDS-UPDRS part II (eating, dressing, personal hygiene, and writing). Results No association was found between the AST and MDS-UPDRS part III, indicating that AST discriminates well (discriminative validity) between apraxia and parkinsonism. Furthermore, AST was associated with ADL and Hoehn & Yahr stage (convergent validity). Conclusions AST is a short and valid test to rule out or detect apraxia in Parkinson’s disease.

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Sentence comprehension and praxis deficits in Parkinson's disease

Cited by 106 publications

References 0 publications

Early dysfunctions of fronto-parietal praxis networks in Parkinson’s disease

Early dysfunctions of fronto-parietal praxis networks in Parkinson’s disease

Sentence processing in Lewy body spectrum disorder: The role of working memory

Short and valid assessment of apraxia in Parkinson’s disease

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