Sensory thresholds obtained from MEG data: Cortical psychometric functions

Witton, Caroline; Patel, T.; Furlong, Paul L.; Henning, G. Bruce; Worthen, Siân F.; Talcott, Joel B.

doi:10.1016/j.neuroimage.2012.08.013

Cited by 5 publications

(4 citation statements)

References 46 publications

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“…Bishop (2007) has provided a critical review of the use of this method in research of developmental disorders. It is also possible to construct “cortical psychometric functions” from auditory evoked responses measured with neurophysiological data, a method which shows promise for bias-free estimates of threshold (Witton et al, 2012). Yet there are challenges associated with using neuroimaging techniques with children (Witton, Furlong & Seri, 2013) and for the majority of studies, psychophysics will remain the method of choice.…”

Section: Discussionmentioning

confidence: 99%

Psychophysical measurements in children: challenges, pitfalls, and considerations

Witton

Talcott

Henning

2017

PeerJ

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Measuring sensory sensitivity is important in studying development and developmental disorders. However, with children, there is a need to balance reliable but lengthy sensory tasks with the child’s ability to maintain motivation and vigilance. We used simulations to explore the problems associated with shortening adaptive psychophysical procedures, and suggest how these problems might be addressed. We quantify how adaptive procedures with too few reversals can over-estimate thresholds, introduce substantial measurement error, and make estimates of individual thresholds less reliable. The associated measurement error also obscures group differences. Adaptive procedures with children should therefore use as many reversals as possible, to reduce the effects of both Type 1 and Type 2 errors. Differences in response consistency, resulting from lapses in attention, further increase the over-estimation of threshold. Comparisons between data from individuals who may differ in lapse rate are therefore problematic, but measures to estimate and account for lapse rates in analyses may mitigate this problem.

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Section: Discussionmentioning

confidence: 99%

Psychophysical measurements in children: challenges, pitfalls, and considerations

Witton

Talcott

Henning

2017

PeerJ

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“…Some strategies to account for inattentional bias and high lapse rate include indexing the lapse rate through statistical methods such as checking consistency of reversal points [ 106 ], or estimating threshold through post-hoc fitting of psychometric function on QUEST-based procedures rather than taking the staircase reversal average [ 109 ]. Lapses may also be physiologically monitored through recording of eye movements or posture [ 106 , 110 ] or using neurophysiological correlates [ 111 ]. Furthermore, investigators may opt to develop novel strategies to minimise likelihood of lapses through improving task engagement by children, such as through gamified approaches e.g.…”

Section: Discussionmentioning

confidence: 99%

Full-field stimulus threshold testing: a scoping review of current practice

Shi

Hall

Thompson

2023

Eye

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The full-field stimulus threshold (FST) is a psychophysical measure of whole-field retinal light sensitivity. It can assess residual visual function in patients with severe retinal disease and is increasingly being adopted as an endpoint in clinical trials. FST applications in routine ophthalmology clinics are also growing, but as yet there is no formalised standard guidance for measuring FST. This scoping review explored current variability in FST conduct and reporting, with an aim to inform further evidence synthesis and consensus guidance. A comprehensive electronic search and review of the literature was carried out according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis Extension for Scoping Reviews (PRISMA-ScR) checklist. Key source, participant, methodology and outcomes data from 85 included sources were qualitatively and quantitatively compared and summarised. Data from 85 sources highlight how the variability and insufficient reporting of FST methodology, including parameters such as units of flash luminance, colour, duration, test strategy and dark adaptation, can hinder comparison and interpretation of clinical significance across centres. The review also highlights an unmet need for paediatric-specific considerations for test optimisation. Further evidence synthesis, empirical research or structured panel consultation may be required to establish coherent standardised guidance on FST methodology and context or condition dependent modifications. Consistent reporting of core elements, most crucially the flash luminance equivalence to 0 dB reference level is a first step. The development of criteria for quality assurance, calibration and age-appropriate reference data generation may further strengthen rigour of measurement.

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“…In the WF condition, neurophysiological sensory sensitivity to the gap might be highly correlated with its psychophysical threshold. Indeed, amplitude of gap-evoked responses has been shown to increase as a function of gap duration, and be correlated with the psychological threshold of each participant ( Witton et al, 2012 ). Therefore, we assume that differences in N1m amplitude for the 0-ms gap in the WF condition might be related to individual differences in the sensitivity to gaps.…”

Section: Discussionmentioning

confidence: 99%

“… Eggermont (2000) suggested that the secondary auditory cortex and anterior auditory field are also involved in gap detection. Because the N1m response to the sound marker was suggested to be related to the psychophysical threshold in humans ( Witton et al, 2012 ), the N1m sources, such as the supra temporal plane, could be involved in gap detection as well. In humans, tonotopic organization in auditory cortex has been verified with MEG ( Romani et al, 1982 ; Pantev et al, 1988 ), EEG ( Bertrand et al, 1988 ), and fMRI ( Talavage et al, 2000 ; Formisano et al, 2003 ).…”

Section: Discussionmentioning

confidence: 99%

Cortical activity associated with the detection of temporal gaps in tones: a magnetoencephalography study

Mitsudo

Hironaga

Mori

2014

Front. Hum. Neurosci.

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We used magnetoencephalogram (MEG) in two experiments to investigate spatio-temporal profiles of brain responses to gaps in tones. Stimuli consisted of leading and trailing markers with gaps between the two markers of 0, 30, or 80 ms. Leading and trailing markers were 300 ms pure tones at 800 or 3200 Hz.Two conditions were examined: the within-frequency (WF) condition in which the leading and trailing markers had identical frequencies, and the between-frequency (BF) condition in which they had different frequencies. Using minimum norm estimates (MNE), we localized the source activations at the time of the peak response to the trailing markers. Results showed that MEG signals in response to 800 and 3200 Hz tones were localized in different regions within the auditory cortex, indicating that the frequency pathways activated by the two markers were spatially represented.The time course of regional activity (RA) was extracted from each localized region for each condition. In Experiment 1, which used a continuous tone for the WF 0-ms stimulus, the N1m amplitude for the trailing marker in the WF condition differed depending on gap duration but not tonal frequency. In contrast, N1m amplitude in BF conditions differed depending on the frequency of the trailing marker. In Experiment 2, in which the 0-ms gap stimulus in the WF condition was made from two markers and included an amplitude reduction in the middle, the amplitude in WF and BF conditions changed depending on frequency, but not gap duration.The difference in temporal characteristics betweenWF and BF conditions could be observed in the RA.

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Sensory thresholds obtained from MEG data: Cortical psychometric functions

Cited by 5 publications

References 46 publications

Psychophysical measurements in children: challenges, pitfalls, and considerations

Psychophysical measurements in children: challenges, pitfalls, and considerations

Full-field stimulus threshold testing: a scoping review of current practice

Cortical activity associated with the detection of temporal gaps in tones: a magnetoencephalography study

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