Sensory system development influences the ontogeny of trace eyeblink conditioning

Goldsberry, Mary E.; Freeman, John H.

doi:10.1002/dev.21468

Cited by 5 publications

(3 citation statements)

References 51 publications

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“…Indeed, recent work from our laboratory shows that when pups are trained with a vibrotactile CS they are capable of learning trace EBC as early as P17–18 (Goldsberry & Freeman, 2016). These data suggest that hippocampal development is not the sole limiting factor in the development of trace EBC.…”

Section: Introductionmentioning

confidence: 99%

Sensory system development influences the ontogeny of hippocampal associative coding and trace eyeblink conditioning

Goldsberry

Kim

Freeman

2017

Neurobiology of Learning and Memory

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Until recently, it was believed that hippocampal development was the primary rate-limiting factor in the developmental emergence of hippocampal forms of learning, such as trace eyeblink conditioning (EBC). Indeed, hippocampal neuronal activity shows an age-related increase in both complexity and task responsiveness during trace EBC. However, recent work from our laboratory suggests that sensory system development may also play a role. Training with the earlier-developing somatosensory system results in an earlier emergence of trace EBC in rats, suggesting that the development of sensory input to the hippocampus may influence the development of trace EBC. The goal of the current study was to examine the activity of hippocampal CA1 pyramidal cells during acquisition of trace EBC with an early-developing somatosensory CS. Rat pups were trained with a vibration CS on postnatal days (P) 17–19, P21–23, and P24–26 while CA1 pyramidal cell activity was recorded. Results indicated that CA1 neurons show an age-related increase in responsiveness to trial events. Although the magnitude of neuronal responding showed age-related increases in activity, all three age groups demonstrated learning-related increases in firing rate magnitude and peaks in firing rate were evident both at CS onset and offset. These findings suggest that the ontogeny of trace eyeblink conditioning is related to both hippocampal and sensory system development.

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Section: Introductionmentioning

confidence: 99%

Sensory system development influences the ontogeny of hippocampal associative coding and trace eyeblink conditioning

Goldsberry

Kim

Freeman

2017

Neurobiology of Learning and Memory

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“…Similarly, canonical visual system development is also not completed at this age (Shen and Colonnese, 2016). Although some reports indicate that auditory conditioning can be performed in rats as young as P12 (Hyson and Rudy, 1984;Rudy and Hyson, 1982), in terms of a cerebellar context, reliable auditory conditioning can only be performed at P17-P18 onward (Goldsberry and Freeman, 2017;Nicholson and Freeman, 2003). Thus, age must be strictly controlled while designing control experiments for possible adaptive tasks.…”

Section: Considerations For Development Of Novel Adaptive Locomotor Tmentioning

confidence: 99%

Cerebellar contribution to locomotor behavior: A neurodevelopmental perspective

Sathyanesan

Gallo

2019

Neurobiology of Learning and Memory

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The developmental trajectory of the formation of cerebellar circuitry has significant implications for locomotor plasticity and adaptive learning at later stages. While there is a wealth of knowledge on the development of locomotor behavior in human infants, children, and adolescents, pre-clinical animal models have fallen behind on the study of the emergence of behavioral motifs in locomotor function across postnatal development. Since cerebellar development is protracted, it is subject to higher risk of genetic or environmental disruption, potentially leading to abnormal behavioral development. This highlights the need for more sophisticated and specific functional analyses of adaptive cerebellar behavior within the context of whole-body locomotion across the entire span of postnatal development. Here we review evidence on cerebellar contribution to adaptive locomotor behavior, highlighting methodologies employed to quantify and categorize behavior at different developmental stages, with the ultimate goal of following the course of early behavioral alterations in neurodevelopmental disorders. Since experimental paradigms used to study cerebellar behavior are lacking in both specificity and applicability to locomotor contexts, we highlight the use of the Erasmus Ladder - an advanced, computerized, fully automated system to quantify adaptive cerebellar learning in conjunction with locomotor function. Finally, we emphasize the need to develop objective, quantitative, behavioral tasks which can track changes in developmental trajectories rather than endpoint measurement at the adult stage of behavior.

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“…Interestingly, this is also around the time when electrical properties of neurons in the rat DCN mature with increases in the amplitude of the afterhyperpolarization, a prolonged interval between the first and second evoked action potential, and an increase in afterhyperpolarization amplitude for hyperpolarization-induced rebound spikes [ 233 ]. This is also when climbing fiber pruning nears completion [ 234 ] and rats are first able to acquire eyeblink conditioning to either tones or lights paired with shock [ 201 , 235 , 236 , 237 , 238 , 239 ], although they can acquire conditioned responses at early time points if other stimuli are used, including two shocks [ 196 ] or direct brain stimulation [ 240 ].…”

Section: The Perineuronal Netmentioning

confidence: 99%

The Role of Cerebellar Intrinsic Neuronal Excitability, Synaptic Plasticity, and Perineuronal Nets in Eyeblink Conditioning

Schreurs,

O’Dell,

Wang

2024

Biology

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Evidence is strong that, in addition to fine motor control, there is an important role for the cerebellum in cognition and emotion. The deep nuclei of the mammalian cerebellum also contain the highest density of perineural nets—mesh-like structures that surround neurons—in the brain, and it appears there may be a connection between these nets and cognitive processes, particularly learning and memory. Here, we review how the cerebellum is involved in eyeblink conditioning—a particularly well-understood form of learning and memory—and focus on the role of perineuronal nets in intrinsic membrane excitability and synaptic plasticity that underlie eyeblink conditioning. We explore the development and role of perineuronal nets and the in vivo and in vitro evidence that manipulations of the perineuronal net in the deep cerebellar nuclei affect eyeblink conditioning. Together, these findings provide evidence of an important role for perineuronal net in learning and memory.

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Sensory system development influences the ontogeny of trace eyeblink conditioning

Cited by 5 publications

References 51 publications

Sensory system development influences the ontogeny of hippocampal associative coding and trace eyeblink conditioning

Sensory system development influences the ontogeny of hippocampal associative coding and trace eyeblink conditioning

Cerebellar contribution to locomotor behavior: A neurodevelopmental perspective

The Role of Cerebellar Intrinsic Neuronal Excitability, Synaptic Plasticity, and Perineuronal Nets in Eyeblink Conditioning

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