Sensory recovery following decellularized nerve allograft transplantation for digital nerve repair

Abstract

This study reported preliminary clinical experience of using decelluarised nerve allograft material for repair of digital nerve defect in five hand injury patients. From October 2009 to July 2010, five patients with traumatic nerve defect were treated with nerve repair using AxoGen® nerve allograft (AxoGen Inc, Alachua, FL) in California Hospital Medical Center. All patients were followed at least for 12 months, and sensory recovery and signs of infection or rejection were documented by a hand therapist. Average two-point discrimination was 6 mm, and average Semmes-Weinstein Monofilaments test was 4.31. No wound infections or signs of rejections were observed at wound site. All patients reported sensory improvement during the follow-up period after operation. It is believed that decellularised nerve allografts may provide a readily available option for repair of segmental nerve defect.

A Multicenter, Prospective, Randomized, Pilot Study of Outcomes for Digital Nerve Repair in the Hand Using Hollow Conduit Compared With Processed Allograft Nerve

“…9,12,22,26 Early clinical data and outcomes reported from an ongoing registry on processed nerve allograft have demonstrated meaningful levels of recovery in nerve gaps up to 50 mm in length. 2,4,7,13,23 The purpose of our study was to compare the outcomes for digital nerve gap reconstruction with hollow conduit versus allograft in a multicenter prospective, randomized, double-blind pilot study.…”

Decellularized Nerves for Upper Limb Nerve Reconstruction: A Systematic Review of Functional Outcomes

“…By crosschecking the references of the six articles, we found one additional article, making a total of seven studies. [11][12][13][14][15][16][17] Given the novelty of the method, the first study on decellularized nerve use in a clinical setting was published in 2009. 15 A total of 131 injuries were covered by the seven studies.…”

“…Except for one study that prepared the nerve using cryopreservation, 15 all nerves were produced by the same manufacturer (AxoGen [Alachua, FL]) using a detergent processing method. [11][12][13][14][15]17 Before use, decellularized nerves were taken from frozen storage and thawed in the operating room. The subsequent steps of the surgical procedure depended on the surgeon.…”

Újabb ismeretek a szövetépítés (tissue engineering) lehetőségeiről a kézsebészetben. Irodalmi áttekintés

“…Ilyen esetekben azonban a donorterületen az eltávolított érzőideg hiánya jelentős pa-ÖSSZEFOGLALÓ KÖZLEMÉNY naszokat okozhat. Guo és mtsai az autológ idegtranszplantáció helyett acelluláris idegallograftokkal végzett átültetéssel jó eredményeket értek el [25].…”