Sensory Reactivity at 1 and 2 Years Old is Associated with ASD Severity During the Preschool Years

Grzadzinski, Rebecca; Donovan, Kevin; Truong, Kinh; Nowell, Sallie W.; Lee, Helen; Sideris, John; Turner‐Brown, Lauren; Baranek, Grace T.; Watson, Linda R.

doi:10.1007/s10803-020-04432-4

Cited by 28 publications

(23 citation statements)

References 47 publications

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“…Findings from empirical research lend some support to this theory. Atypical patterns of sensory responsiveness, for example, have been linked to the core features of RRBs [ 6 , 11 , 12 , 13 , 14 , 15 ] and social communication in persons on the autism spectrum [ 12 , 16 , 17 , 18 , 19 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Relations between Sensory Responsiveness and Features of Autism in Children

et al. 2020

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Autism is a neurodevelopmental condition defined by differences in social communication and by the presence of restricted and repetitive patterns of behavior, interests, and activities (RRBs). Individuals with autism also commonly present with atypical patterns of sensory responsiveness (i.e., hyporesponsiveness, hyperresponsiveness, and sensory seeking), which are theorized to produce cascading effects across other domains of development. The purpose of this study was to examine differences in sensory responsiveness in children with and without autism (ages 8–18 years), as well as relations between patterns of sensory responsiveness and core and related features of autism. Participants were 50 children with autism and 50 non-autistic peers matched on age and sex. A comprehensive clinical battery included multiple measures of sensory responsiveness, core features of autism, adaptive behavior, internalizing behaviors, cognitive ability, and language ability. Groups significantly differed on all three patterns of sensory responsiveness. Some indices of core and related autism features were robustly associated with all three patterns of sensory responsiveness (e.g., RRBs), while others were more strongly associated with discrete patterns of sensory responsiveness (i.e., internalizing problem behaviors and hyperresponsiveness, language and sensory seeking). This study extends prior work to show that differences in sensory responsiveness that are linked with core and related features of autism persist in older children and adolescents on the spectrum.

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Section: Introductionmentioning

confidence: 99%

Relations between Sensory Responsiveness and Features of Autism in Children

et al. 2020

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“…But additionally, a significant fraction of ASD patients also show abnormal reactions to environmental stimuli such as somatosensory input (Tomchek and Dunn, 2007). In fact, hyper-or hyporeactivity to different stimuli can act as predictor for diagnosis and/or severity of ASD (Grzadzinski et al, 2020;Jussila et al, 2020). The social impairment may in part be due to this altered perception of the environment.…”

Section: Discussionmentioning

confidence: 99%

The Potential Effect of Nav1.8 in Autism Spectrum Disorder: Evidence From a Congenital Case With Compound Heterozygous SCN10A Mutations

Heinrichs

Liu

Zhang

et al. 2021

Front. Mol. Neurosci.

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Apart from the most prominent symptoms in Autism spectrum disorder (ASD), namely deficits in social interaction, communication and repetitive behavior, patients often show abnormal sensory reactivity to environmental stimuli. Especially potentially painful stimuli are reported to be experienced in a different way compared to healthy persons. In our present study, we identified an ASD patient carrying compound heterozygous mutations in the voltage-gated sodium channel (VGSC) Nav1.8, which is preferentially expressed in sensory neurons. We expressed both mutations, p.I1511M and p.R512∗, in a heterologous expression system and investigated their biophysical properties using patch-clamp recordings. The results of these experiments reveal that the p.R512∗ mutation renders the channel non-functional, while the p.I1511M mutation showed only minor effects on the channel’s function. Behavioral experiments in a Nav1.8 loss-of-function mouse model additionally revealed that Nav1.8 may play a role in autism-like symptomatology. Our results present Nav1.8 as a protein potentially involved in ASD pathophysiology and may therefore offer new insights into the genetic basis of this disease.

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“…Sensory symptoms in the areas of hearing, vision, smell, and touch are prevalent in ASD patients, and can even appear during infancy. 20 21 Atypical sensory features may have detrimental cascading effects on social communication and reactivity, 21 and it was reported that sensory symptoms, such as reactivity, at 1 and 2 years of age are associated with ASD severity among preschool children. 20 Although we used simple hearing screening questions instead of a comprehensive evaluation of hearing, we found consistently increased risks of mortality for negative response to the question related to hearing impairment.…”

Section: Discussionmentioning

confidence: 99%

Mortality of Children with Autism Spectrum Disorder Using Data from a Large-Scale Korean National Cohort

et al. 2021

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Purpose This study aimed to investigate the association between autism spectrum disorder (ASD) diagnosis and mortality among children using the data from a large-scale national cohort of Korean infants and children. We also explored the association between hearing impairment detected during early infancy and mortality. Materials and Methods We performed a retrospective cohort study using the nationwide claims data of the Republic of Korea. Children born between 2007 and 2014 (n=3598904) were followed up until 2020. Cox proportional hazard models were used to examine the association between ASD diagnosis and mortality among children. Then, in order to evaluate the association between hearing impairment and mortality, Cox proportional hazard models were built using the responses related to hearing impairment asked during the first health screening (at age 4–6 months). Results Of the 3598904 children born between 2007 and 2014, 32878 children (0.9%) were diagnosed with ASD until the end of 2020. We identified that ASD diagnosis was associated with higher mortality among children [hazard ratio (HR)=2.5, 95% confidence interval (CI): 2.2–2.9]. This association was stronger among girls (HR=4.8, 95% CI: 3.9–5.8) compared to boys (HR=1.9, 95% CI: 1.6–2.2). We found that hearing impairment detected during infancy was associated with higher mortality among children with ASD diagnosis. Conclusion ASD diagnosis was associated with higher mortality among Korean children. This association was stronger in girls than in boys. Hearing impairment detected during infancy was also associated with higher mortality among children diagnosed with ASD.

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Sensory Reactivity at 1 and 2 Years Old is Associated with ASD Severity During the Preschool Years

Cited by 28 publications

References 47 publications

Relations between Sensory Responsiveness and Features of Autism in Children

Relations between Sensory Responsiveness and Features of Autism in Children

The Potential Effect of Nav1.8 in Autism Spectrum Disorder: Evidence From a Congenital Case With Compound Heterozygous SCN10A Mutations

Mortality of Children with Autism Spectrum Disorder Using Data from a Large-Scale Korean National Cohort

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