Sensory Processing in Schizophrenia: Neither Simple nor Intact

Javitt, Daniel C.

doi:10.1093/schbul/sbp110

Cited by 274 publications

(212 citation statements)

References 54 publications

Supporting

Mentioning

192

Contrasting

Unclassified

Order By: Relevance

“…They found defects in the processing of data in terms of the ability to detect emotional states, predictable and purposeful behavior, and the intensification of negative symptoms in these patients (13). The results of the present study are consisted with those of Javitt et al (2009) is consistent (9).…”

Section: Discussionsupporting

confidence: 87%

The Impact of the Sensory Integration Approach on Positive and Negative Symptoms in a Patient With Non-Paranoid Schizophrenia: A Case Report

Jadidi

Mirshoja

2016

Middle East J Rehabil Health

View full text Add to dashboard Cite

Introduction: One of the problems that people with schizophrenia face is the inability to understand and interpret the sensory input from the environment. This report aims to describe the effects of the sensory integration approach on non-paranoid schizophrenia. The treatment involved eight sessions held 3 days a week and lasting 45 minutes each. The patient had a defined Iranians form social relationships schizophrenia evaluated and treatment. Sensory integration therapy in these patients focused on the following elements: vestibular and proprioceptive senses, exercises to improve walking, improving upper extremity coordination and movement, writing activities, cognitive skills, activities of daily living, and family therapy. Case Presentation: The subject (A.H.) was a 32-year-old male graduate student with no history of previous hospitalization. His diagnosis was schizophrenia. The reason for his hospitalization was that he was angry and violent toward his family. In addition, the patient had limited verbal and nonverbal skills, issues with self-control, and restricted community involvement. The results of the patient's treatment for schizophrenia was assessed via a questionnaire on social skills. Conclusions: After eight sessions, increased awareness of the environment, improved posture and gait pattern, improved motivation and enjoyment, improved patient tolerance, improved appearance and personal hygiene, loss of purposeful behavior, a realistic plan of action every day, improved attention span, improved decision-making skills, and improved community involvement and coping skills were achieved. The environment is rich in sensory stimuli. The integration and processing of each individual senses creates different behavioral responses. The results showed that a sensory integration approach combined with drug therapy is an effective treatment for patients with schizophrenia.

show abstract

Section: Discussionsupporting

confidence: 87%

The Impact of the Sensory Integration Approach on Positive and Negative Symptoms in a Patient With Non-Paranoid Schizophrenia: A Case Report

Jadidi

Mirshoja

2016

Middle East J Rehabil Health

View full text Add to dashboard Cite

show abstract

“…MMN deficits are one of the features in schizophrenia that indicate severe abnormalities in fundamental brain processes of prediction and inference (Corlett et al, 2007;Friston, Stephan, Montague, & Dolan, 2014;Stephan et al, 2006). This is further corroborated by parallel evidence for a key role of NMDAR in MMN generation and in the pathophysiology of schizophrenia (Coyle, 2006;Javitt, 2009;Umbricht & Krljes, 2005).…”

Section: Schizophreniamentioning

confidence: 84%

“…Therefore several studies used aMMN (or its magnetic counterpart, MMNm) to study automatic sensorycognitive processes in depression (Iv, Zhao, Gong, Chen, & Miao, 2010;K€ ahk€ onen et al, 2007;Lepist€ o et al, 2004;Pang et al, 2014;Takei et al, 2009) and BP (Andersson, Barder, Hellvin, Løvdahl, & Malt, 2008;Takei et al, 2010). Takei et al applied magnetoencephalography to measure information processing deficit in depression (2009) andBP (2010). In the study of depressive patients, MMNm was elicited in response to duration and frequency changes of pure-tone stimuli and in response to an across-category change in a vowel.…”

Section: Mood Disordersmentioning

confidence: 99%

Visual mismatch negativity (vMMN): A review and meta-analysis of studies in psychiatric and neurological disorders

Kremláček

Kreegipuu

Tales

et al. 2016

Cortex

113

View full text Add to dashboard Cite

The visual mismatch negativity (vMMN) response is an event-related potential (ERP) component, which is automatically elicited by events that violate predictions based on prior events. VMMN experiments use visual stimulus repetition to induce predictions, and vMMN is obtained by subtracting the response to rare unpredicted stimuli from those to frequent stimuli. One increasingly popular interpretation of the mismatch response postulates that vMMN, similar to its auditory counterpart (aMMN), represents a prediction error response generated by cortical mechanisms forming probabilistic representations of sensory signals. Here we discuss the physiological and theoretical basis of vMMN and review thirty-three studies from the emerging field of its clinical applications, presenting a meta-analysis of findings in schizophrenia, mood disorders, substance abuse, neurodegenerative disorders, developmental disorders, deafness, panic disorder and hypertension. Furthermore, we include reports on aging and maturation as they bear upon many clinically relevant conditions. Surveying the literature we found that vMMN is altered in several clinical populations which is in line with aMMN findings. An important potential advantage of vMMN however is that it allows the investigation of deficits in predictive processing in cognitive domains which rely primarily on visual information; a principal sensory modality and thus of vital importance in environmental information processing and response, and a modality which arguably may be more sensitive to some pathological changes. However, due to the relative infancy of research in vMMN compared to aMMN in clinical populations its potential for clinical application is not yet fully appreciated. The aim of this review and meta-analysis therefore is to present, in a detailed systematic manner, the findings from clinically-based vMMN studies, to discuss their potential impact and application, to raise awareness of this measure and to improve our understanding of disease upon fundamental aspects of visual information processing. Furthermore, we include reports on aging and maturation as they bear upon many clinically relevant conditions. Surveying the literature we found that vMMN is altered in several 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 clinical populations which is in line with aMMN findings. An important potential advantage of vMMN however is that it allows the investigation of deficits in predictive processing in cognitive domains which rely primarily on visual information; a principal sensor...

show abstract

“…A growing literature has shown information processing deficits in animal models of psychosis and schizophrenic patients (Javitt, 2009). Abnormalities in sensorimotor gating, the ability to filter irrelevant stimuli in order to attend to current pressing ones, have been consistently reported as impaired in schizophrenic patients and in healthy controls receiving stimulants.…”

Section: Discussionmentioning

confidence: 99%