Sensory Processing Disorders are Associated with Duration of Current Episode and Severity of Side Effects

Serafini, Gianluca; Engel‐Yeger, Batya; Vázquez, Gustavo; Pompili, Maurizio; Amore, Mario

doi:10.4306/pi.2017.14.1.51

Cited by 20 publications

(15 citation statements)

References 43 publications

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“…In contrast, a Sensation Seeking pattern on the AASP tends to correlate with more adaptive behaviour, such as higher positive affect (Engel-Yeger and Dunn, 2011a) and lower sleep disturbances (Engel-Yeger and Shochat, 2012). Correlates of SPP in healthy adults show continuity with similar studies in people with affective and anxiety disorders, which have shown that such disorders correspond with higher rates of Sensory Sensitivity, Sensory Avoidance and Low Registration patterns and with lower rates of Sensation Seeking (Serafini et al, 2017).…”

Section: Sensory Processing In Healthy Adultssupporting

confidence: 74%

An exploration of sensory processing patterns and their association with demographic factors in healthy adults

Machingura

Kaur

Lloyd

et al. 2019

IJOT

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Purpose Previous research has provided limited evidence on whether and how demographic factors associate with sensory processing patterns (SPP) in adults. This paper aims to examine relationships between SPPs and sociodemographic factors of age, sex, education and ethnicity in healthy adults. Design/methodology/approach A cross-sectional study design was used. A total of 71 adult participants was recruited from the community, using convenience sampling. Each participant completed the Adolescent/Adult Sensory Profile (AASP) and the Depression Anxiety Stress Scales – short version (DASS-21). Demographic information on age, sex, education and ethnicity was collected. Results were analysed using descriptive statistics and multivariate analyses of covariance (MANCOVA). Findings SPPs, as measured by the AASP, were significantly correlated to demographic factors of age and education after controlling for emotional distress using the DASS-21. A statistically significant multivariate effect was found across the four dependent variables (low registration, seeking, sensitivity and avoiding) for the age category, F = 6.922, p = 0.009, ηp2 = 0.145, in the presence of a covariate DASS. The education category showed significance only in the seeking domain (p = 0.008, ηp2 = 0.10) after controlling for DASS. There was no significant correlation between SPPs and gender or ethnicity. Results also indicated that mean scores of participants in this study were “similar to most people” as standardised in the AASP. Research limitations/implications This was a cross-sectional study with limitations including that the study used a relatively small sample and was based on self-reported healthy participants. Practical implications SPPs may correlate with healthy adults’ age and to a lesser extent education. This suggests that it might be helpful to consider such demographic factors when interpreting SPPs in clinical populations, although further research in larger samples is needed to reach firmer conclusions about possible implications of demographic variables. Originality/value The findings in this paper add to the growing evidence that suggest that SPPs vary with sociodemographic factors.

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Section: Sensory Processing In Healthy Adultssupporting

confidence: 74%

An exploration of sensory processing patterns and their association with demographic factors in healthy adults

Machingura

Kaur

Lloyd

et al. 2019

IJOT

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“…In addition to the emotional problems, sensorimotor abnormalities are often present in depression 69 . Clinical data indicate that patients with major depression have decreased volume and surface area of somatosensory cortex and abnormal sensory processing 70 , 71 . Our study examines the cellular underpinning of sensory alterations caused by psychological stress in a mouse model.…”

Section: Discussionmentioning

confidence: 99%

Selective activation of parvalbumin interneurons prevents stress-induced synapse loss and perceptual defects

Yang

et al. 2017

Mol Psychiatry

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Stress, a prevalent experience in modern society, is a major risk factor for many psychiatric disorders. Although sensorimotor abnormalities are often present in these disorders, little is known about how stress affects the sensory cortex. Combining behavioral analyses with in vivo synaptic imaging, we show that stressful experiences lead to progressive, clustered loss of dendritic spines along the apical dendrites of layer (L) 5 pyramidal neurons (PNs) in the mouse barrel cortex, and such spine loss closely associates with deteriorated performance in a whisker-dependent texture discrimination task. Furthermore, the activity of parvalbumin-expressing inhibitory interneurons (PV+ INs) decreases in the stressed mouse due to reduced excitability of these neurons. Importantly, both behavioral defects and structural changes of L5 PNs are prevented by selective pharmacogenetic activation of PV+ INs in the barrel cortex during stress. Finally, stressed mice raised under environmental enrichment (EE) maintain normal activation of PV+ INs, normal texture discrimination, and L5 PN spine dynamics similar to unstressed EE mice. Our findings suggest that the PV+ inhibitory circuit is crucial for normal synaptic dynamics in the mouse barrel cortex and sensory function. Pharmacological, pharmacogenetic, and environmental approaches to prevent stress-induced maladaptive behaviors and synaptic malfunctions converge on the regulation of PV+ IN activity, pointing to a potential therapeutic target for stress-related disorders.

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“…Therefore, we hypothesized increased insular cortex activity among euthymic patients to be related to impaired sensory integration as well as processing present experiences [ 55 ]. Noteworthy, the aforementioned abilities are thought to be associated with the duration of episodes of depression and mania [ 56 ]. In our study, typical band ALFF analysis revealed increased activity in the left insula.…”

Section: Discussionmentioning

confidence: 99%

Time-Frequency Characterization of Resting Brain in Bipolar Disorder during Euthymia—A Preliminary Study

et al. 2021

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The goal of this paper is to investigate the baseline brain activity in euthymic bipolar disorder (BD) patients by comparing it to healthy controls (HC) with the use of a variety of resting state functional magnetic resonance imaging (rs-fMRI) analyses, such as amplitude of low frequency fluctuations (ALFF), fractional ALFF (f/ALFF), ALFF-based functional connectivity (FC), and r egional homogeneity (ReHo). We hypothesize that above-mentioned techniques will differentiate BD from HC indicating dissimilarities between the groups within different brain structures. Forty-two participants divided into two groups of euthymic BD patients (n = 21) and HC (n = 21) underwent rs-fMRI evaluation. Typical band ALFF, slow-4, slow-5, f/ALFF, as well as ReHo indexes were analyzed. Regions with altered ALFF were chosen as ROI for seed-to-voxel analysis of FC. As opposed to HC, BD patients revealed: increased ALFF in left insula; increased slow-5 in left middle temporal pole; increased f/ALFF in left superior frontal gyrus, left superior temporal gyrus, left middle occipital gyrus, right putamen, and bilateral thalamus. There were no significant differences between BD and HC groups in slow-4 band. Compared to HC, the BD group presented higher ReHo values in the left superior medial frontal gyrus and lower ReHo values in the right supplementary motor area. FC analysis revealed significant hyper-connectivity within the BD group between left insula and bilateral middle frontal gyrus, right superior parietal gyrus, right supramarginal gyrus, left inferior parietal gyrus, left cerebellum, and left supplementary motor area. To our best knowledge, this is the first rs-fMRI study combining ReHo, ALFF, f/ALFF, and subdivided frequency bands (slow-4 and slow-5) in euthymic BD patients. ALFF, f/ALFF, slow-5, as well as REHO analysis revealed significant differences between two studied groups. Although results obtained with the above methods enable to identify group-specific brain structures, no overlap between the brain regions was detected. This indicates that combination of foregoing rs-fMRI methods may complement each other, revealing the bigger picture of the complex resting state abnormalities in BD.

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Sensory Processing Disorders are Associated with Duration of Current Episode and Severity of Side Effects

Cited by 20 publications

References 43 publications

An exploration of sensory processing patterns and their association with demographic factors in healthy adults

An exploration of sensory processing patterns and their association with demographic factors in healthy adults

Selective activation of parvalbumin interneurons prevents stress-induced synapse loss and perceptual defects

Time-Frequency Characterization of Resting Brain in Bipolar Disorder during Euthymia—A Preliminary Study

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