Sensory neuropathy in vasculitis

Seo, Jeong-Hwan; Ryan, Hewitt F.; Claussen, Gwendolyn C.; Thomas, T.; Oh, Shin J.

doi:10.1212/01.wnl.0000137017.45065.3e

Cited by 54 publications

(22 citation statements)

References 21 publications

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“…42 Motor as well as sensory fibers are usually affected, but sometimes there is pure sensory neuropathy. 4,15,25,28,43 Proximal reductions in amplitude due to pseudo-conduction blocks may be identified for up to 9 days in 10% to 25% of patients before loss of conduction from the infarcted distal nerve stump. 25,28 Some conduction blocks are more long-lasting yet reversible 44 and may be due to dysfunction of myelin versus fluctuating axonal ischemia.…”

Section: Testing Electrodiagnostic Studiesmentioning

confidence: 99%

Approach to Vasculitic Neuropathies

Lacomis¹,

Živković²

2007

Journal of Clinical Neuromuscular Disease

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Since vasculitic neuropathy is treatable and potentially debilitating, clinicians should develop an approach to neuropathy that increases the likelihood of uncovering existing systemic or nonsystemic vasculitis. The presence of a connective tissue disease, systemic vasculitis, asymmetric or non--length-dependent axonal polyneuropathy, or multiple axonal mononeuropathies should heighten suspicion, but vasculitic neuropathy can also present as a distal symmetric polyneuropathy with or without other organ involvement. Electrodiagnostic testing utilizing extensive nerve conductions may be helpful in identifying features suggestive of vasculitic neuropathy and in selecting an abnormal nerve and muscle for biopsy confirmation. An array of laboratory tests may lead to identification of a systemic disorder that is either characterized by or predisposes to vasculitic neuropathy. The mainstays of treatment are corticosteroids and cyclophosphamide, but other drugs are used in specific conditions. With early diagnosis and careful monitoring of treatment regimens, the prognosis is usually good.

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Section: Testing Electrodiagnostic Studiesmentioning

confidence: 99%

Approach to Vasculitic Neuropathies

Lacomis¹,

Živković²

2007

Journal of Clinical Neuromuscular Disease

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“…At the time of the diagnosis, most patients show signs of mixed neuropathy and liver and cardiac involvement may be present [53]. Vasculitis may rarely present with an isolated sensory neuropathy, but sural nerve conduction is commonly impaired, reflecting the involvement of large nerve fibres [54 ].…”

Section: Neuropathologic Investigationsmentioning

confidence: 99%

Small fibre neuropathies

Lauria

2005

Current Opinion in Neurology

111

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Detection of small fibre impairment allows earlier diagnosis of neuropathy and could be used as an outcome measure in future regenerative neuropathy trials. Standardization of skin biopsy can have an important impact on clinical practice and research. Further studies are needed to assess the reliability of current neurophysiologic techniques for testing small fibre function in peripheral neuropathies and the correlation with well established neuropathologic examination.

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“…Pure sensory vasculitic neuropathy has been described but is rare [2,3]. Randomised controlled trial data is lacking, however treatment with various immunosuppressants has been suggested [1].…”

Section: Sirsmentioning

confidence: 99%

“…Distal, symmetric sensory neuropathy secondary to nonsystemic vasculitis [2] is rare but may show a benign course [3]. Randomised controlled trials of therapy in nonsystemic vasculitic neuropathy have not been carried out [3], but anecdotal case series suggest treatment with immunosuppressive therapies such as cyclophosphamide, azathioprine and steroids [1].…”

Section: Sirsmentioning

confidence: 99%