Sensory nerve-mediated and nitric oxide-dependent cutaneous vasodilation in normotensive and prehypertensive non-Hispanic blacks and whites

Wong, Brett J.; Turner, Casey G; Miller, Jeri L.; Walker, Demetria C; Sebeh, Yesser; Hayat, Matthew J.; Otis, Jeffrey S.; Quyyumi, Arshed A.

doi:10.1152/ajpheart.00177.2020

Cited by 12 publications

(29 citation statements)

References 56 publications

(39 reference statements)

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“…Black or African American adults (Hurr et al, 2018;Miller et al, 2021;Patik et al, 2018;Wong et al, 2020). This might indicate endothelial dysfunction and acutely increased cardiovascular risk in women currently using OCP.…”

Section: Endothelium-dependent Vasodilatationmentioning

confidence: 99%

Microvascular endothelial function following cessation of long‐term oral contraceptive pill use: A case report

Turner

Stanhewicz

Nielsen

et al. 2022

Experimental Physiology

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New Findings What is the main observation in this case?The main observation of this case report is substantial improvement in cutaneous microvascular endothelial function after cessation of long‐term use of a fourth‐generation oral contraceptive pill. This improvement appears independent of relative changes in the contribution of nitric oxide. What insights does it reveal?Our findings suggest that cessation of long‐term, fourth‐generation oral contraceptive pill use improves endothelial function within 20 months of cessation. Abstract The purpose of this case report was to evaluate in vivo endothelial function and nitric oxide (NO)‐dependent vasodilatation before and after the cessation of long‐term (11–12 years) fourth‐generation oral contraceptive pill (OCP) use in one young, healthy and premenopausal woman. This retrospective analysis includes data from six experimental visits: three visits during months 133–144 of fourth‐generation OCP use and three visits 19–22 months after OCP cessation. Endothelium‐dependent and NO‐dependent vasodilatation were assessed in the cutaneous microvasculature using laser‐Doppler flowmetry, a rapid local heating protocol (39°C, 0.1°C/s) and pharmacological perfusion through intradermal microdialysis fibres. The participant had consistent medical history and lifestyle behaviours throughout both hormonal exposures. Data are presented as the mean (SD). Endothelium‐dependent vasodilatation was 42 (10)% of site‐specific maximal cutaneous vascular conductance (CVCmax) during OCP use and 63 (10)%CVCmax after OCP cessation (49% increase). Nitric oxide‐dependent vasodilatation was 70 (5)% contribution of NO during OCP use and 60 (15)%NO after OCP cessation (15% reduction). Baseline blood flow was greater after OCP cessation, but maximal blood flow was reduced. Data from this case report support a substantial increase in cutaneous microvascular endothelial function assessed via local heating after cessation of long‐term use of a fourth‐generation OCP, which does not appear to be attributable to increased NO bioavailability. Overall, these data suggest an improvement in endothelial and microvascular function after the cessation of long‐term use of a fourth‐generation OCP.

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Section: Endothelium-dependent Vasodilatationmentioning

confidence: 99%

Microvascular endothelial function following cessation of long‐term oral contraceptive pill use: A case report

Turner

Stanhewicz

Nielsen

et al. 2022

Experimental Physiology

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“…Furthermore, our previous work demonstrated that the administration of 98% cinnamaldehyde via intradermal microdialysis increased cutaneous vascular conductance by ;37 %max from baseline. 16 Noteworthy, the elevation in cutaneous vascular conductance associated with the administration of cinnamaldehyde by intradermal microdialysis was comparable to the elevations observed by both local skin heating to 398C 3,29,30 and whole-body heating, [30][31][32][33] with each heating modality increasing cutaneous vascular conductance to approximately 30-50 %max from baseline. Taken together, these findings show that TRPA1 channel activation in humans in vivo can induce a robust cutaneous vasodilatory response.…”

Section: Discussion Trpa1 Channel-induced Cutaneous Vasodilationmentioning

confidence: 59%

TRPA1 Channel Activation With Cinnamaldehyde Induces Cutaneous Vasodilation Through NOS, but Not COX and KCa Channel, Mechanisms in Humans

Kataoka

Kenny

Nishiyasu

et al. 2022

Journal of Cardiovascular Pharmacology

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“…The pathophysiology of sensory neuropathy is linked to microvascular and endothelial dysfunction (Cameron et al., 2001) and we originally hypothesized that this dilatation would be attenuated in our patient group. Indeed, prehypertensive adults and non‐hypertensive black men and women have an attenuated cutaneous sensory nerve‐mediated vasodilatation response, reflective of and accompanied by reductions in endothelium‐dependent NO‐mediated dilatation (Patik et al., 2018; Turner et al., 2020; Wong et al., 2020). In these studies, as with ours, local heating applied to the skin was used to activate the sensory nerve‐mediated increase in skin blood flow.…”

Section: Discussionmentioning

confidence: 99%

“…In this study we did not directly inhibit sensory nerves and as such, the direct contribution of sensory nerves to our responses cannot be quantified. Local inhibition of sensory nerves with topical anaesthetic cream attenuates the initial peak by ∼50% in the forearm (Hodges et al., 2015; Minson et al., 2001; Wong et al., 2020). Our data did not reveal a difference in the magnitude of the initial peak response in women with a history of PE, and we hypothesize that this is indicative of a preserved neurogenically mediated dilatation in these women.…”

Section: Discussionmentioning

confidence: 99%

“…The pathophysiology of sensory neuropathy is linked to microvascular and endothelial dysfunction (Cameron et al., 2001) and sensory nerve dysfunction exacerbates vascular dysfunction in rodent models of hypertension (Watson et al., 2002). Indeed, overt hypertension may be an independent risk factor for sensory neuropathy in humans (Cohen et al., 1998; Hebert et al., 2017), and prehypertensive adults have an attenuated cutaneous sensory nerve‐mediated vasodilatation response, reflective of and accompanied by reductions in endothelium‐dependent NO‐mediated dilatation (Turner et al., 2020; Wong et al., 2020). Together, these data suggest that sensory nerve‐mediated microvascular dilatation may be attenuated in populations with attenuated NO bioavailability, and that this attenuation may contribute to the development of CVD.…”

Section: Introductionmentioning

confidence: 99%

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Women with a history of preeclampsia have preserved sensory nerve‐mediated dilatation in the cutaneous microvasculature

Pyevich

Alexander

Stanhewicz

2022

Experimental Physiology

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New Findings What is the central question of this study?Are sensory nerve‐mediated vasodilatation and the NO‐dependent contribution to that response attenuated in the cutaneous microvasculature of women who have had preeclampsia? What is the main finding and its importance?Women who have had preeclampsia demonstrate attenuated microvascular endothelium‐dependent dilatation compared to women with a history of uncomplicated pregnancy. However, there are no differences in sensory nerve‐mediated vasodilatation between groups. This suggests that the neurogenic response is not altered following preeclampsia, and that the NO‐dependent vasodilatation of the neurogenic response is not related to endothelium‐dependent NO‐mediated dilatation in these women. Abstract Women who have had preeclampsia (PE) demonstrate microvascular endothelial dysfunction, mediated in part by reduced nitric oxide (NO)‐dependent mechanisms. Localized heating of the skin induces a biphasic vasodilatation response: a sensory nerve‐mediated initial peak, followed by a sustained endothelium‐dependent plateau. We have previously shown that the endothelium‐dependent plateau is attenuated in PE. However, it is unknown if the sensory nerve‐mediated initial peak is similarly attenuated. Therefore, the purpose of this study was to examine the effect of PE history on sensory nerve‐mediated vasodilatation and the NO‐dependent contribution to that response. We hypothesized that PE would have an attenuated initial peak and a reduced NO‐dependent contribution to that response compared to women with a history of normotensive pregnancy (healthy controls, HC). Nine HC (31 ± 4 years) and nine PE (28 ± 6 years) underwent a standard local heating protocol (42°C; 0.1°C s–1). Two intradermal microdialysis fibres were placed in the skin of the ventral forearm for the continuous local delivery of lactated Ringer solution alone (control) or 15‐mM NG‐nitro‐l‐arginine methyl ester for nitric oxide synthase (NOS) inhibition. Red blood cell flux was measured at each site by laser Doppler flowmetry (LDF). Cutaneous vascular conductance was calculated (CVC = LDF/mean arterial pressure) and normalized to maximum (%CVCmax; 28‐mM SNP + local heat 43°C). There were no differences in the initial peak between groups (HC: 79 ± 8 vs. PE: 80 ± 10%CVCmax; P = 0.936). NOS inhibition attenuated the initial peak in both HC (57 ± 18% CVCmax; P = 0.003) and PE (54 ± 10%CVCmax; P = 0.002). However, there were no differences in the NO‐dependent portion of the initial peak (HC: 23 ± 16 vs. PE: 24 ± 9%; P = 0.777). The local heating plateau (HC: 99 ± 4 vs. PE: 88 ± 7%CVCmax; P = 0.001) and NO contribution to the plateau (HC: 31 ± 9 vs. PE: 17 ± 14%; P = 0.02) were attenuated in PE. There was no relation between NO‐dependent dilatation in the initial peak and NO‐dependent dilatation in the plateau across groups (R2 = 0.005; P = 0.943). Women who have had PE demonstrate attenuated microvascular endothelium‐dependent dilatation. However, there are no differences in sensory nerve‐mediated vasodila...

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Sensory nerve-mediated and nitric oxide-dependent cutaneous vasodilation in normotensive and prehypertensive non-Hispanic blacks and whites

Cited by 12 publications

References 56 publications

Microvascular endothelial function following cessation of long‐term oral contraceptive pill use: A case report

Microvascular endothelial function following cessation of long‐term oral contraceptive pill use: A case report

TRPA1 Channel Activation With Cinnamaldehyde Induces Cutaneous Vasodilation Through NOS, but Not COX and KCa Channel, Mechanisms in Humans

Women with a history of preeclampsia have preserved sensory nerve‐mediated dilatation in the cutaneous microvasculature

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