Sensory nerve fibers containing calcitonin gene-related peptide in gastrocnemius, latissimus dorsi and erector spinae muscles and thoracolumbar fascia in mice

Barry, Christine; Kestell, Garreth; Gillan, Maeve; Haberberger, Rainer Viktor; Gibbins, Ian L.

doi:10.1016/j.neuroscience.2015.01.062

Cited by 44 publications

(51 citation statements)

References 61 publications

(75 reference statements)

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“…The identified nerves include such with a presumably nociceptive potential (i.e., positive for CGRP staining) as well as such that clearly possess a nociceptive capacity (i.e., positive for SP staining). Interestingly, a study investigating the distribution and density of CGRP-positive fibers in different tissues reported a three times higher density in the LF than in the spinal muscles [14]. Furthermore, the density of nociceptive fibers was found to be increased in the inner layer of the rat LF, following chronic inflammation induced by Complete Freund's Adjuvant [15].…”

Section: Resultsmentioning

confidence: 99%

The Lumbodorsal Fascia as a Potential Source of Low Back Pain: A Narrative Review

Wilke

Schleip

Klingler

et al. 2017

BioMed Research International

100

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The lumbodorsal fascia (LF) has been proposed to represent a possible source of idiopathic low back pain. In fact, histological studies have demonstrated the presence of nociceptive free nerve endings within the LF, which, furthermore, appear to exhibit morphological changes in patients with chronic low back pain. However, it is unclear how these characteristics relate to the aetiology of the pain. In vivo elicitation of back pain via experimental stimulation of the LF suggests that dorsal horn neurons react by increasing their excitability. Such sensitization of fascia-related dorsal horn neurons, in turn, could be related to microinjuries and/or inflammation in the LF. Despite available data point towards a significant role of the LF in low back pain, further studies are needed to better understand the involved neurophysiological dynamics.

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Section: Resultsmentioning

confidence: 99%

The Lumbodorsal Fascia as a Potential Source of Low Back Pain: A Narrative Review

Wilke

Schleip

Klingler

et al. 2017

BioMed Research International

100

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“…CGRP and SP belongs to the family of tachykinins. Neurons containing one or both tachykinins have been already identified in rat trigeminal ganglion, SGs (Lee et al, 1985;Morris et al, 2005) and in mice afferents of leg and back muscles (Barry et al, 2015), where they were commonly associated with blood vessels, suggesting a role related to vascular function. In fact, it has been documented that the release of CGRP and SP from perivascular afferent nerve endings causes neurogenic vasodilatation (Benemei et al, 2009).…”

Section: Cgrp-spmentioning

confidence: 97%

Immunohistochemical Properties of the Peripheral Neurons Projecting to the Pig Bulbospongiosus Muscle

Botti

Ragionieri

Cacchioli

et al. 2016

The Anatomical Record

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Retrograde neuronal tracing and single labelling immunofluorescence methods were used to define the neurochemical content of the peripheral autonomic and sensitive neurons projecting to the male pig striated bulbospongiosus muscle (BSM). The retrograde fluorescent neuronal tracer Fast Blue (FB) was injected into the left bulbospongiosus muscle of four intact impuberal pigs. After a 10-day survival time, the ipsilateral sacral sympathetic trunk ganglia (STGs), the caudal mesenteric ganglion (CMG), and the sacral spinal ganglia (SGs) were collected from each animal. In FB1 neurons of these ganglia, the presence of cathecolamine-(tyrosine hydroxylase-TH), acetylcholine-(vesicular acetylcholine transporter-VChAT), or nitric oxide-synthesizing (neuronal Nitric Oxide Synthase-nNOS) enzymes and of some biologically active peptides (calcitonine gene-related peptide-CGRP, Leu-Enkephaline-LENK, Neuropeptide Y-NPY, Substance P-SP and Vasoactive Intestinal Peptide-VIP) were studied. The ipsilateral STGs FB1 neurons showed immunoreactivity principally for TH and NPY and in decreasing order for VIP, VChAT, SP, CGRP, nNOS, and LENK. The left CMG FB1 neurons were immunoreactive to TH and NPY, and in smaller proportions for VIP, LENK, VChAT, CGRP, nNOS, and SP. The ipsilateral SGs FB1 neurons resulted immunoractive for CGRP, LENK, NPY, nNOS, SP, and VChAT. The heterogeneous neurochemical content of the peripheral neurons projecting to the pig BSM allows us to hypothesize the involvement of autonomic ganglia in the activity of both blood vessels and striated fibers of the muscle and the involvement of sensory ganglia in the afferent transmission from the muscle to spinal cord and in antidromic mechanisms that causes the relaxation of the BSM blood vessels. Anat Rec, 299:1192Rec, 299: -1202Rec, 299: , 2016. V C 2016 Wiley Periodicals, Inc.Key words: immunohistochemistry; retrograde tracing; peripheral neurons; bulbospongiosus muscle; pigThe striated and paired bulbospongiosus muscle (BSM) is a perineal muscle associated to the genital organs. It is a single muscle in male mammals, while in females it is divided in vestibule and vulva constrictor muscles. In the male, it originates laterally from the tunica albuginea of the penis corpora spongiosa and terminates on the perineum median septum (Schaller, 1992).

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“…There is emerging evidence that in many complex neurological diseases that environmental factors such as stress and anxiety greatly influence disease onset, progression, and maintenance of the clinical phenotype [79], the pathophysiological effects of unmanaged stress can include increased tension in the muscles of the neck and shoulders especially in females. Based on immunohistochemical studies, skeletal muscles are predominantly innervated by CGRP-containing neurons that facilitate pain signal transmission to the spinal cord [80–82]. Chronic muscle overload and tension in the neck and shoulders can lead to persistent fiber contraction, local ischemia, and the release of pro-inflammatory mediators, including bradykinin, glutamate, and CGRP, which can promote sensitization and activation of primary nociceptors [3].…”

Section: Migraine Risk Factors and Cgrp: Role Of Stress Anxiety Andmentioning

confidence: 99%

Diverse Physiological Roles of Calcitonin Gene-Related Peptide in Migraine Pathology: Modulation of Neuronal-Glial-Immune Cells to Promote Peripheral and Central Sensitization

Durham

2016

Curr Pain Headache Rep

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The neuropeptide calcitonin gene-related peptide (CGRP) is implicated in the underlying pathology of migraine by promoting the development of a sensitized state of primary and secondary nociceptive neurons. The ability of CGRP to initiate and maintain peripheral and central sensitization is mediated by modulation of neuronal, glial, and immune cells in the trigeminal nociceptive signaling pathway. There is accumulating evidence to support a key role of CGRP in promoting cross excitation within the trigeminal ganglion that may help to explain the high co-morbidity of migraine with rhinosinusitis and temporomandibular joint disorder. In addition, there is emerging evidence that CGRP facilitates and sustains a hyperresponsive neuronal state in migraineurs mediated by reported risk factors such as stress and anxiety. In this review, the significant role of CGRP as a modulator of the trigeminal system will be discussed to provide a better understanding of the underlying pathology associated with the migraine phenotype.

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Sensory nerve fibers containing calcitonin gene-related peptide in gastrocnemius, latissimus dorsi and erector spinae muscles and thoracolumbar fascia in mice

Cited by 44 publications

References 61 publications

The Lumbodorsal Fascia as a Potential Source of Low Back Pain: A Narrative Review

The Lumbodorsal Fascia as a Potential Source of Low Back Pain: A Narrative Review

Immunohistochemical Properties of the Peripheral Neurons Projecting to the Pig Bulbospongiosus Muscle

Diverse Physiological Roles of Calcitonin Gene-Related Peptide in Migraine Pathology: Modulation of Neuronal-Glial-Immune Cells to Promote Peripheral and Central Sensitization

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