Sensory-motor integration in focal dystonia

Avanzino, Laura; Tinazzi, Michèle; Ionta, Silvio; Fiorio, Mirta

doi:10.1016/j.neuropsychologia.2015.07.008

Cited by 69 publications

(51 citation statements)

References 169 publications

(177 reference statements)

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“…Several experimental approaches aimed to promote the re-organization of sensory-motor regions to improve motor control and symptoms of dystonia (Avanzino et al, 2015b). Available information in dystonia shows reduced accuracy in extrapolating temporal properties during the perception of body movements.…”

Section: Translational Aspects In Rehabilitation Strategiesmentioning

confidence: 99%

Time Processing and Motor Control in Movement Disorders

Avanzino

Pelosin

Vicario

et al. 2016

Front. Hum. Neurosci.

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The subjective representation of “time” is critical for cognitive tasks but also for several motor activities. The neural network supporting motor timing comprises: lateral cerebellum, basal ganglia, sensorimotor and prefrontal cortical areas. Basal ganglia and associated cortical areas act as a hypothetical “internal clock” that beats the rhythm when the movement is internally generated. When timing information is processed to make predictions on the outcome of a subjective or externally perceived motor act, cerebellar processing and outflow pathways appear to be primarily involved. Clinical and experimental evidence on time processing and motor control points to a dysfunction of the neural networks involving basal ganglia and cerebellum in movement disorders. In some cases, temporal processing deficits could directly contribute to core motor features of the movement disorder, as in the case of bradykinesia in Parkinson's disease. For other movement disorders, the relationship between abnormal time processing and motor performance is less obvious and requires further investigation, as in the reduced accuracy in predicting the temporal outcome of a motor act in dystonia. We aim to review the literature on time processing and motor control in Parkinson's disease, dystonia, Huntington's disease, and Tourette syndrome, integrating the available findings with current pathophysiological models; we will highlight the areas in which future explorations are warranted, as well as the aspects of time processing in motor control that present translational aspects in future rehabilitation strategies. The subjective representation of “time” is critical for cognitive tasks but also for motor activities. Recently, greater attention has been devoted to improve our understanding of how temporal information becomes integrated within the mechanisms of motor control. Experimental evidence recognizes time processing in motor control as a complex neural function supported by diffuse cerebral networks including cortical areas, cerebellum, and other subcortical structures (Ivry and Spencer, 2004; Coull and Nobre, 2008). Timing is an essential component of motor control primarily within two types of motor tasks: (i) when producing sequential rhythmic movements or sustained movements of a definite duration (explicit timing); (ii) when the temporal information is used implicitly, such as when coordinating our movements to those of moving objects or individuals within the external environment (implicit timing). In this review, we will provide a brief description of the neural network supporting motor timing focusing only on instrumental information to explain the link between timing and motor control in movement disorders. Then we will review available data on motor timing in Parkinson's disease, dystonia, Huntington's disease, and Tourette syndrome, and discuss how this body of evidence integrates with the available information on the pathophysiology of these movement disorders. Finally, we will discuss the translational aspects of the exp...

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Section: Translational Aspects In Rehabilitation Strategiesmentioning

confidence: 99%

Time Processing and Motor Control in Movement Disorders

Avanzino

Pelosin

Vicario

et al. 2016

Front. Hum. Neurosci.

Self Cite

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“…Specifically, the most common dystonic syndrome, torsion dystonia, also known as torticollis, is considered to be associated with abnormal metabolism and neural response within the basal ganglia (Galardi et al, 1996). Emphasis has been given to the sensory and proprioceptive disturbances, which often resemble clinical observations of patients affected by CRPS (Mugge et al, 2013;Avanzino et al, 2015). Emphasis has been given to the sensory and proprioceptive disturbances, which often resemble clinical observations of patients affected by CRPS (Mugge et al, 2013;Avanzino et al, 2015).…”

Section: Clinical Findings Linking Crps To Basal Ganglia Dysfunctionmentioning

confidence: 99%

“…Focal damage to the putamen has been identified as the most frequent cause of secondary dystonia (Bhatia and Marsden, 1994;Hartmann et al, 1998). Emphasis has been given to the sensory and proprioceptive disturbances, which often resemble clinical observations of patients affected by CRPS (Mugge et al, 2013;Avanzino et al, 2015). A controversial aspect to consider is whether dystonia in CRPS is a psychogenic movement disorder, since dystonic CRPS-I patients also have non-organic signs (Verdugo and Ochoa, 2000;Lang and Chen, 2010).…”

Section: Clinical Findings Linking Crps To Basal Ganglia Dysfunctionmentioning

confidence: 99%

Basal ganglia dysfunction in complex regional pain syndrome – A valid hypothesis?

Azqueta‐Gavaldon¹,

Schulte-Göcking²,

Storz³

et al. 2016

European Journal of Pain

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“…Primary dysfunctions associated with dystonia include loss of inhibition at various levels of the central nervous system, alteration of synaptic plasticity, and sensory dysfunction [2]. Dystonia is increasingly conceptualized as a disorder of motor organization, programming and execution [3], and sensorimotor integration (i.e., the ability to use sensory information to guide motor program execution) [4]. Indeed, experimental studies have noted alterations of spatial [5] and temporal discrimination [6] of sensory stimuli in a variety of focal and generalized dystonia syndromes.…”

Section: Introductionmentioning

confidence: 99%

Explicit Agency in Patients with Cervical Dystonia: Altered Recognition of Temporal Discrepancies between Motor Actions and Their Feedback

et al. 2016

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BackgroundAbnormalities in the cognitive processing of movement have been demonstrated in patients with dystonia. The sense of agency, which is the experience of initiating and controlling one’s own actions, has never before been studied in these patients.ObjectivesWe investigated whether the sense of agency is altered in patients with cervical dystonia.MethodsWe used an explicit metacognitive agency task in which participants had to catch targets with a cursor by moving a computer’s mouse. The task included several conditions in which the control over the cursor could be disrupted by adding a spatial or a temporal discrepancy between the mouse and the cursor’s movements. Participants had to acknowledge these discrepancies and reflect them in metacognitive judgements of agency.ResultsTwenty cervical dystonia patients and 20 matched controls were included in the study. Despite performing equally well as the matched controls, cervical dystonia patients did not fully recognize alterations of agency when a temporal lag was added between their movement and the visual feedback. Moreover, they relied predominantly on their perceived performance to provide judgements of agency and less on their objective degree of controls. There was no correlation between agency scores and clinical severity of dystonia measured by the Toronto Western Spasmodic Torticollis Rating Scale.ConclusionWe demonstrated an abnormal processing of agency in cervical dystonia patients, even for motor actions not affected by dystonia. The exact contribution of abnormal agency to dystonia pathophysiology remains to be clarified.

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Sensory-motor integration in focal dystonia

Cited by 69 publications

References 169 publications

Time Processing and Motor Control in Movement Disorders

Time Processing and Motor Control in Movement Disorders

Basal ganglia dysfunction in complex regional pain syndrome – A valid hypothesis?

Explicit Agency in Patients with Cervical Dystonia: Altered Recognition of Temporal Discrepancies between Motor Actions and Their Feedback

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