Sensory-Motor Deficits in Children with Fetal Alcohol Spectrum Disorder Assessed Using a Robotic Virtual Reality Platform

Williams, Loriann; Jackson, Carl P. T.; Choe, Noreen; Pelland, Lucie; Scott, Stephen H.; Reynolds, James N.

doi:10.1111/acer.12225

Cited by 27 publications

(37 citation statements)

References 50 publications

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“…Deficits in behavior and cognition have long been identified as consequences of ethanol exposure during nervous system development [2, 23, 32, 39, 40, 47, 53, 55, 58, 72]. An estimated 1%-5% of children are diagnosed with fetal alcohol spectrum disorders (FASDs; [41]) which encompass, in decreasing order of severity, full-blown Fetal Alcohol Syndrome (FAS), partial FAS (pFAS), and alcohol-related neurodevelopmental disorders (ARNDs)[12].…”

Section: Introductionmentioning

confidence: 99%

Effects of moderate prenatal ethanol exposure and age on social behavior, spatial response perseveration errors and motor behavior

Hamilton

Barto

Rodríguez

et al. 2014

Behavioural Brain Research

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Persistent deficits in social behavior are among the major negative consequences associated with exposure to ethanol during prenatal development. Prior work from our laboratory has linked deficits in social behavior following moderate prenatal alcohol exposure (PAE) in the rat to functional alterations in the ventrolateral frontal cortex [21]. In addition to social behaviors, the regions comprising the ventrolateral frontal cortex are critical for diverse processes ranging from orofacial motor movements to flexible alteration of behavior in the face of changing consequences. The broader behavioral implications of altered ventrolateral frontal cortex function following moderate PAE have, however, not been examined. In the present study we evaluated the consequences of moderate PAE on social behavior, tongue protrusion, and flexibility in a variant of the Morris water task that required modification of a well-established spatial response. PAE rats displayed deficits in tongue protrusion, reduced flexibility in the spatial domain, increased wrestling, and decreased investigation, indicating that several behaviors associated with ventrolateral frontal cortex function are impaired following moderate PAE. A linear discriminant analysis revealed that measures of wrestling and tongue protrusion provided the best discrimination of PAE rats from saccharin-exposed control rats. We also evaluated all behaviors in young adult (4-5 mos.) or older (10-11 mos.) rats to address the persistence of behavioral deficits in adulthood and possible interactions between early ethanol exposure and advancing age. Behavioral deficits in each domain persisted well into adulthood (10-11 mos.), however, there was no evidence that age enhances the effects of moderate PAE within the age ranges that were studied.

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Section: Introductionmentioning

confidence: 99%

Effects of moderate prenatal ethanol exposure and age on social behavior, spatial response perseveration errors and motor behavior

Hamilton

Barto

Rodríguez

et al. 2014

Behavioural Brain Research

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show abstract

“…Including measures of balance and motor performance will be necessary in future studies to complement kinematic measures of sensory attention and postural control to examine effects at the levels of both impairment and function. 47 Finally, since this is a feasibility and exploratory study, results are limited by our small sample size and multiple comparisons, and cannot be generalizable without further studies.…”

Section: Immediate Effects: Sensory Attentionmentioning

confidence: 94%

“…Since only the trajectory data near the stimulus frequencies were of interest (ranging from 0.24 to 1.11 Hz), 4 th order Butterworth band pass filter was applied. 47 A Welch smoothing window was applied to avoid spectral leakage, along with a tolerance interval to detect response peaks within 0.02 Hz of the stimulus. To detect phase wrapping, phase (timing of response) was calculated from the timing of the peak cross-correlation of stimulus and response signals and converted to degrees.…”

Section: Data Reductionmentioning

confidence: 99%

Virtual Sensorimotor Balance Training for Children With Fetal Alcohol Spectrum Disorders: Feasibility Study

et al. 2015

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Children completed the training protocol, demonstrating the feasibility of the STABEL system. Differences in postural sway velocity post-STABEL training may have been affected by fatigue, warranting further investigation. Limited immediate effects suggest more practice is needed to affect sensory attention; however, entrainment gain changes suggest the STABEL system provoked vestibular responses during balance practice.

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“…Researchers have reported that deficits in sensory processing and sensory-motor functioning are related to adaptive behaviour and academic performance in home and school settings among children with FASD [43,44]. Impairments in sensory-motor integration and motor development have been noted in children and youth with FASD, with particularly pronounced difficulties in younger children [45].…”

Section: Sensory-motor Functioning Needsmentioning

confidence: 99%

Interventions for Fetal Alcohol Spectrum Disorder: Meeting Needs Across the Lifespan

Pei¹,

Flannigan²,

Walls³

et al. 2016

Int J Neurorehabilitation Eng

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Background: Fetal Alcohol Spectrum Disorder (FASD) is a complicated disability resulting in a diverse, highneeds population for whom intervention is critical to optimize functional competence and reduce the emergence of adverse outcomes. Researchers have been evaluating intervention efforts for FASD to inform practice and policy decision-making. Objective: The current review provides a synopsis of the current state of evidence for intervention research in FASD, with consideration of how our growing understanding of the unique needs of individuals with FASD might inform future intervention initiatives. Method: A comprehensive literature review was conducted across a number of databases using multiple search terms linking FASD and intervention. Results: Existing evidence-based interventions are limited and focus predominantly on the school-aged population, thereby neglecting adolescents and adults. Future research efforts are needed to support individuals with FASD across the entire lifespan, particularly during transitions and for individuals involved in the legal system. Conclusion: As the field of FASD continues to grow, so must the quality and quantity of intervention research. It is through cross-discipline intervention research efforts that the evidence supporting best practices will be established, and policies can be implemented to reflect best uses of available funds to support this population.

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Sensory-Motor Deficits in Children with Fetal Alcohol Spectrum Disorder Assessed Using a Robotic Virtual Reality Platform

Cited by 27 publications

References 50 publications

Effects of moderate prenatal ethanol exposure and age on social behavior, spatial response perseveration errors and motor behavior

Effects of moderate prenatal ethanol exposure and age on social behavior, spatial response perseveration errors and motor behavior

Virtual Sensorimotor Balance Training for Children With Fetal Alcohol Spectrum Disorders: Feasibility Study

Interventions for Fetal Alcohol Spectrum Disorder: Meeting Needs Across the Lifespan

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