2013
DOI: 10.1186/1756-6606-6-53
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Sensory input is required for callosal axon targeting in the somatosensory cortex

Abstract: BackgroundSensory input is generally thought to be necessary for refining and consolidating neuronal connections during brain development. We here report that cortical callosal axons in somatosensory cortex require sensory input for their target selection in contralateral cortex.ResultsEliminating sensory input to either hemisphere by unilateral transection of infraorbital nerve (ION) prevents target selection of callosal axons in contralateral cortex. Strikingly, blocking sensory input bilaterally, by simulta… Show more

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Cited by 25 publications
(32 citation statements)
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“…For example, regionspecific callosal projections are differentially affected by balanced activity across hemispheres (Huang et al, 2013;Suárez et al, 2014). Our findings of a dorsomedial to ventrolateral pattern of contralateral axon innervation are in accordance with previous findings, whereby contralateral innervation recapitulates the dorsoventral axonal arrangement within the callosal tract (Zhou et al, 2013).…”
Section: Discussionsupporting
confidence: 92%
“…For example, regionspecific callosal projections are differentially affected by balanced activity across hemispheres (Huang et al, 2013;Suárez et al, 2014). Our findings of a dorsomedial to ventrolateral pattern of contralateral axon innervation are in accordance with previous findings, whereby contralateral innervation recapitulates the dorsoventral axonal arrangement within the callosal tract (Zhou et al, 2013).…”
Section: Discussionsupporting
confidence: 92%
“…This process is, however, extremely vulnerable to deleterious effects including sensory deprivation. In mice, transection of ION can lead to loss of barrel structures and callosal connection in the somatosensory cortex [5, 6, 22]. However, few studies have explored behavioral alterations beyond the whisker-related somatosensory system in these mice.…”
Section: Discussionmentioning
confidence: 99%
“…The alterations in the brain caused by the early sensory deprivation are not limited to loss of barrels. For example, the early sensory deprivation also affects synaptic plasticity [14, 15], dendritic spine refinement and formation of local circuitry [1620], and inter-hemispheric in the somatosensory cortex [22]. We thus speculated the spatial memory and social memory deficits in ION-transected mice are the consequence of global structural and functional alterations in brain circuits after the early sensory deprivation.…”
Section: Discussionmentioning
confidence: 99%
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