Sensory Impairments and Mortality in an Elderly Community Population: A Six-year Follow-up Study

Appollonio, Ildebrando; Carabellese, Corrado; Magni, Eugenio; Frattola, L.; Trabucchi, Marco

doi:10.1093/ageing/24.1.30

Cited by 86 publications

(71 citation statements)

References 50 publications

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“…Relationships between visual impairment and mortality have been noted in other studies. [19][20][21][22]24,31 The Beaver Dam Eye Study found that, although persons with visual acuity of 20/40 or worse were 1.6 times as likely to die within 5 years as those with better visual acuity, the relationship disappeared after adjusting for other clinical conditions such as hypertension and diabetes mellitus. 17 A similar relationship remained significant even after adjustment in the Melbourne Visual Impairment Project.…”

Section: Discussionmentioning

confidence: 99%

“…[9][10][11][12][13] Although previous studies have demonstrated a relationship between sensory impairment and quality of life, they conflict on its relationship with mortality. [14][15][16][17][18][19][20][21][22][23][24] Cross-sectional design, small study sample, self-reported visual impairment, and limited adjustment for the independent influence of other chronic medical conditions have limited prior studies.…”

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confidence: 99%

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Visual Acuity, Contrast Sensitivity, and Mortality in Older Women: Study of Osteoporotic Fractures

Pedula

Coleman

Hillier

et al. 2006

J American Geriatrics Society

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OBJECTIVES:To determine whether poorer visual acuity and contrast sensitivity are independent risk factors for all-cause and traumatic mortality in older women. DESIGN: Twelve-year prospective cohort study (1986)(1987)(1988)(1989)(1990)(1991)(1992)(1993)(1994)(1995)(1996)(1997)(1998)(1999)(2000)(2001)(2002)(2003). SETTING: Four U.S. clinical centers. PARTICIPANTS: Nine thousand seven hundred four postmenopausal white women aged 65 and older. MEASUREMENTS: Habitually corrected binocular visual acuity and low-and high-frequency contrast sensitivity were measured at baseline using a standard protocol. A study physician adjudicated the primary cause of death from death certificates and medical record review. RESULTS: During an average of 12.2 years of followup, 3,427 women died (35%), 72 (0.7%) from traumatic events. In multivariate models adjusted for age, chronic medical problems, and smoking, all-cause mortality risk was 19% greater for persons in the worst quartile of visual acuity than for those in the best (hazard ratio (HR) 5 1.19, P 5.008) and 39% greater for persons with the worst contrast sensitivity (HR 5 1.39, Po.001) than for those with the best. Traumatic mortality risk was 2.4 times greater for women with the worst contrast sensitivity than for those with the best (HR 5 2.44, P 5.03). CONCLUSION: Poorer visual acuity and contrast sensitivity are associated with greater risk of traumatic and allcause mortality in older women, even after controlling for demographic and clinical characteristics. Although further research is necessary to determine how treating reversible causes of visual impairment or improving current refraction affects mortality in older women, clinical detection and follow-up of these visual impairments holds promise for identifying those who are at risk of mortality from other systemic conditions. J Am Geriatr Soc 54:1871-1877, 2006. Key words: mortality; visual acuity; contrast sensitivity V isual impairment is one of the most common conditions affecting older individuals. Approximately 92% of persons aged 70 and older require corrective lenses, and 2% are legally blind without correction.1 Additionally, 14% of persons aged 70 to 74 and 32% of persons aged 85 and older report trouble seeing even while wearing glasses. 1Visual impairment likely reflects biological aging and disease processes, and its health effect is substantial. Impaired vision increases the risk of falls, hip fractures, 2-8 and decline in functional status. [9][10][11][12][13] Although previous studies have demonstrated a relationship between sensory impairment and quality of life, they conflict on its relationship with mortality.14-24 Cross-sectional design, small study sample, self-reported visual impairment, and limited adjustment for the independent influence of other chronic medical conditions have limited prior studies.It was hypothesized that any association between visual impairment and all-cause mortality is likely a consequence of other comorbidities related to vision and mortality. It was also hypothesize...

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Visual Acuity, Contrast Sensitivity, and Mortality in Older Women: Study of Osteoporotic Fractures

Pedula

Coleman

Hillier

et al. 2006

J American Geriatrics Society

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“…People, who suffer from hearing problems, find their health problems more burdensome than do normal hearing people (Lee et al 2005;Dalton et al 2003;Crandell et al 2003;Pope & Sowers 2000;Appollonio et al 1995). This interaction is supported by the fact that certain medications prescribed to cure specific health problems can cause hearing problems as a side effect.…”

Section: A the Basic Model For Estimation Of Receipt Of Disability Bmentioning

confidence: 99%

Hearing loss and disability exit: Measurement issues and coping strategies

Christensen¹,

Gupta

2017

Economics & Human Biology

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Standard-Nutzungsbedingungen:Die Dokumente auf EconStor dürfen zu eigenen wissenschaftlichen Zwecken und zum Privatgebrauch gespeichert und kopiert werden.Sie dürfen die Dokumente nicht für öffentliche oder kommerzielle Zwecke vervielfältigen, öffentlich ausstellen, öffentlich zugänglich machen, vertreiben oder anderweitig nutzen.Sofern die Verfasser die Dokumente unter Open-Content-Lizenzen (insbesondere CC-Lizenzen) zur Verfügung gestellt haben sollten, gelten abweichend von diesen Nutzungsbedingungen die in der dort genannten Lizenz gewährten Nutzungsrechte. Terms of use: Documents in Hearing Loss and Disability Exit: Measurement Issues and Coping StrategiesVibeke T. Christensen Nabanita Datta Gupta Martin V. Rasmussen The Institute for the Study of Labor (IZA) in Bonn is a local and virtual international research center and a place of communication between science, politics and business. IZA is an independent nonprofit company supported by Deutsche Post World Net. The center is associated with the University of Bonn and offers a stimulating research environment through its research networks, research support, and visitors and doctoral programs. IZA engages in (i) original and internationally competitive research in all fields of labor economics, (ii) development of policy concepts, and (iii) dissemination of research results and concepts to the interested public. D I S C U S S I O N P A P E R S E R I E SIZA Discussion Papers often represent preliminary work and are circulated to encourage discussion. Citation of such a paper should account for its provisional character. A revised version may be available directly from the author. ABSTRACT Hearing Loss and Disability Exit: Measurement Issues and Coping StrategiesUsing unique representative data containing self-reported functional and clinically measured hearing ability for the Danish population aged 50-64, we estimate the effect of hearing loss on receipt of disability benefits accounting for potential endogeneity of functional hearing. Our identification strategy involves simultaneous estimation of labor supply, functional hearing and coping strategies i.e. using assistive devices at work or informing one's employer about the problem. We find that functional hearing disability significantly increases the likelihood of receiving disability benefits for both men and women. Using assistive devices at the work place decreases the likelihood of going on disability for both genders, whereas telling the employer about the disability increases disability-related exit for both genders, but considerably more so for women. JEL Classification:J26, I12

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“…Age-associated reduction in ankle proprioception (due to age-associated chronic conditions such as knee or hip osteoarthritis and type II diabetes) has been confirmed in aged men and women (Ko et al 2015). Over 10 % of healthy elderly population undergoes a global sensory decline in aging (Appollonio et al 1995;Shaffer and Harrison 2007;Daulatzai 2010;Iwamoto et al 2013b).…”

Section: Sensory Impairment: Multiple Risk Factors Sensory Decline Inmentioning

confidence: 99%

Dysfunctional Sensory Modalities, Locus Coeruleus, and Basal Forebrain: Early Determinants that Promote Neuropathogenesis of Cognitive and Memory Decline and Alzheimer’s Disease

Daulatzai

2016

Neurotox Res

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Sporadic Alzheimer's disease (AD) is a devastating neurodegenerative disorder. It is essential to unravel its etiology and pathogenesis. This should enable us to study the presymptomatic stages of the disease and to analyze and reverse the antemortem behavioral, memory, and cognitive dysfunction. Prima facie, an ongoing chronic vulnerability involving neural insult may lead normal elderly to mild cognitive impairment (MCI) and then to AD. Development of effective preventive and therapeutic strategies to thwart the disease pathology obviously requires a thorough delineation of underlying disruptive neuropathological processes. Our sensory capacity for touch, smell, taste, hearing, and vision declines with advancing age. Declines in different sensory attributes are considered here to be the primary "first-tier pathologies." Olfactory loss is among the first clinical signs of neurodegenerative diseases including AD and Parkinson's disease (PD). Sensory dysfunction in the aged promotes pathological disturbances in the locus coeruleus, basal forebrain, entorhinal cortex, hippocampus, and several key areas of neocortex and brainstem. Hence, sensory dysfunction is the pivotal factor that may upregulate cognitive and memory dysfunction. The age-related constellation of comorbid pathological factors may include apolipoprotein E (APOE) genotype, obesity, diabetes, hypertension, alcohol abuse, head trauma, and obstructive sleep apnea. The concepts and trajectories delineated here are the dynamic pillars of the current hypothesis presented-it postulates that the sensory decline, in conjunction with the above pathologies, is crucial in triggering neurodegeneration and promoting cognitive/memory dysfunction in aging and AD. The application of this thesis can be important in formulating new multifactorial preventive and treatment strategies (suggested here) in order to attenuate cognitive and memory decline and ameliorate pathological dysfunction in aging, MCI, and AD.

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Sensory Impairments and Mortality in an Elderly Community Population: A Six-year Follow-up Study

Cited by 86 publications

References 50 publications

Visual Acuity, Contrast Sensitivity, and Mortality in Older Women: Study of Osteoporotic Fractures

Visual Acuity, Contrast Sensitivity, and Mortality in Older Women: Study of Osteoporotic Fractures

Hearing loss and disability exit: Measurement issues and coping strategies

Dysfunctional Sensory Modalities, Locus Coeruleus, and Basal Forebrain: Early Determinants that Promote Neuropathogenesis of Cognitive and Memory Decline and Alzheimer’s Disease

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