Sensory gating of auditory evoked potentials in rats: effects of repetitive stimulation and the interstimulus interval

Bruin, Natasja de; Ellenbroek, Bart A.; Schaijk, Willie J. van; Cools, Alexander R.; Coenen, A.M.L.; Luijtelaar, E.L.J.M. van

doi:10.1016/s0301-0511(00)00084-3

Cited by 41 publications

(23 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The recovery cycle, that can be as long as 5 s for rat ERP components (De Bruin et al, 2001) and as long as 10 -20 s for humans (Näätänen and Picton, 1987), might cause response decrements in itself or interact with 'real' habituation effects, because it decreases amplitudes due to sensory fatigue instead of learning. Particularly, the early P1 and N1 components can be affected by a recovery cycle (Budd et al, 1998;Carrillo-de-la-Pena and Garcia-Larrea, 1999;De Bruin et al, 2001). Direct evidence for long-term habituation may be obtained when observing response recovery and enhanced rehabituation (Thompson and Spencer, 1966).…”

Section: Discussionmentioning

confidence: 99%

“…Shucard and showed that peak-to-peak amplitudes of the N40/P90 component decreased from the first to the second tone in a passive condition, which was not due to increased latency variability . The studies of De Bruin et al (2001) and Quian Quiroga and Van Luijtelaar (2002) also showed amplitude decrements at an N50 component. Furthermore, Jongsma et al (1998) found amplitude decrements at a positive component of a similar latency, a P50 component, and at N23, P30, and P150 components.…”

Section: Introductionmentioning

confidence: 87%

See 1 more Smart Citation

Effects of stimulus repetitions on the event-related potential of humans and rats

Sambeth

Maes

Quiroga

et al. 2004

International Journal of Psychophysiology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 87%

Effects of stimulus repetitions on the event-related potential of humans and rats

Sambeth

Maes

Quiroga

et al. 2004

International Journal of Psychophysiology

View full text Add to dashboard Cite

“…Thus, despite the face valid similarities of measures that are labeled as gating deficits (eg, P50 gating, PPI gating), 53 this pattern of group deficits but divergence of the individual deficit levels is striking. 54,55 It does appear that there are independent mechanisms of deficits that may well reflect divergent neurobiological substrate dysfunction and genetic architectures.…”

Section: Some Caveats and Challenges To The Endophenotype Approachmentioning

confidence: 99%

Deconstructing Schizophrenia: An Overview of the Use of Endophenotypes in Order to Understand a Complex Disorder

Braff¹,

Freedman²,

Schork³

et al. 2008

FOC

116

View full text Add to dashboard Cite

The genetics of schizophrenia has been approached utilizing a variety of methods. One emerging strategy is the use of endophenotypes in order to understand and identify the functional importance of genetically transmitted, brainbased deficits across schizophrenia kindreds. The endophenotype strategy is a topic of this issue of Schizophrenia Bulletin. Endophenotypes are quantitative, heritable, traitrelated deficits typically assessed by laboratory-based methods rather than clinical observation. Endophenotypes are seen as closer to genetic variation than are clinical symptoms of schizophrenia, and are therefore closely linked to heritable risk factors. There has been a broad expansion of opportunities available to psychiatric neuroscientists who use the endophenotype strategy to understand the genetic basis of schizophrenia. In this context, genetic variation such as single nucleotide polymorphisms (SNPs) induces abnormalities in endophenotypic domains such as neurocognition, neurodevelopment, metabolism, and neurophysiology. This article discusses the challenges that abound in genetic research of schizophrenia, including issues in ascertainment, epistasis, ethnic diversity, and the potentially normalizing effects of secondgeneration antipsychotic medications on neurocognitive and neurophysiological measures. Robust strategies for meeting these challenges are discussed in this review and the subsequent articles in this issue. This article summarizes conceptual advances and progress in the measurement and use of endophenotypes in schizophrenia that form the basis of the multisite National Institute of Mental Health Consortium on the Genetics of Schizophrenia. The endophenotype strategy offers powerful and exciting opportunities to understand the genetically conferred neurobiological vulnerabilities and possible new strong inference and molecularly based treatments for schizophrenia.

show abstract

“…De Bruin et al studied the influence of repetitive stimulation and different ISI on rat AEP components. [4]. In other experiments, animals are the mostly used subjects [5,6], or the experiments focus on AEP P50 sensory gating deficits in schizophrenic patients [7,8].…”

Section: Introductionmentioning

confidence: 99%

Influence of inter-stimulus interval on auditory evoked potentials

Liu

et al. 2005

2005 IEEE Engineering in Medicine and Biology 27th Annual Conference

View full text Add to dashboard Cite

In this research, the influence of the preceding auditor stimulus on the auditory-evoked potential (AEP) of the succeeding stimuli was investigated, when the human subjects were presented with a pair of auditory stimuli. We found that the evoked potential of the succeeding stimulus was inhibited completely by the preceding stimulus, when the inter-stimulus interval (ISI) was shorter than 150 ms. The influence was depended on the ISI of two stimuli, the longer was the ISI, the stronger would be the influence. The inhibitory influence by the preceding stimulus might be caused by the neural refractory effect.

show abstract

Sensory gating of auditory evoked potentials in rats: effects of repetitive stimulation and the interstimulus interval

Cited by 41 publications

References 26 publications

Effects of stimulus repetitions on the event-related potential of humans and rats

Effects of stimulus repetitions on the event-related potential of humans and rats

Deconstructing Schizophrenia: An Overview of the Use of Endophenotypes in Order to Understand a Complex Disorder

Influence of inter-stimulus interval on auditory evoked potentials

Contact Info

Product

Resources

About