Sensory disturbances, inhibitory deficits, and the P50 wave in schizophrenia

Vlček, Přemysl; Bob, Petr; Raboch, J

doi:10.2147/ndt.s64219

Cited by 20 publications

(19 citation statements)

References 126 publications

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“…A consistent observation in schizophrenia is that affected individuals are impaired in their ability to gate irrelevant sensory input ( Patterson et al, 2008 ). It has been proposed that sensory gating deficits lead to a sensory overload, which contributes to cognitive deficits in schizophrenia ( McGhie and Chapman, 1961 ; Shakow, 1963 ; Freedman et al, 1991 ; Bob et al, 2014 ). A commonly used experimental paradigm to study sensory gating is the auditory paired-stimulus paradigm, in which two identical stimuli are presented in close succession ( Adler et al, 1982 ; Bramon et al, 2004 ).…”

Section: Introductionmentioning

confidence: 99%

Positive and Negative Symptoms in Schizophrenia Relate to Distinct Oscillatory Signatures of Sensory Gating

Keil

Romero

Balz

et al. 2016

Front. Hum. Neurosci.

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Oscillatory activity in neural populations and temporal synchronization within these populations are important mechanisms contributing to perception and cognition. In schizophrenia, perception and cognition are impaired. Aberrant gating of irrelevant sensory information, which has been related to altered oscillatory neural activity, presumably contributes to these impairments. However, the link between schizophrenia symptoms and sensory gating deficits, as reflected in oscillatory activity, is not clear. In this electroencephalography study, we used a paired-stimulus paradigm to investigate frequency-resolved oscillatory activity in 22 schizophrenia patients and 22 healthy controls. We found sensory gating deficits in patients compared to controls, as reflected in reduced gamma-band power and alpha-band phase synchrony difference between the first and the second auditory stimulus. We correlated these markers of neural activity with a five-factor model of the Positive and Negative Syndrome Scale. Gamma-band power sensory gating was positively correlated with positive symptoms. Moreover, alpha-band phase synchrony sensory gating was negatively correlated with negative symptoms. A cluster analysis revealed three schizophrenia phenotypes, characterized by (i) aberrant gamma-band power and high positive symptoms, (ii) aberrant alpha-band phase synchrony, low positive, and low negative symptom scores or (iii) by intact sensory gating and high negative symptoms. Our study demonstrates that aberrant neural synchronization, as reflected in gamma-band power and alpha-band phase synchrony, relates to the schizophrenia psychopathology. Different schizophrenia phenotypes express distinct levels of positive and negative symptoms as well as varying degrees of aberrant oscillatory neural activity. Identifying the individual phenotype might improve therapeutic interventions in schizophrenia.

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Section: Introductionmentioning

confidence: 99%

Positive and Negative Symptoms in Schizophrenia Relate to Distinct Oscillatory Signatures of Sensory Gating

Keil

Romero

Balz

et al. 2016

Front. Hum. Neurosci.

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“…They provide a noninvasive approach to study psychophysiological correlates of sensory and/or cognitive processes. Examples of these applications include the use of P50 to measure sensory gating (Olincy and Martin 2005; Vlcek et al 2014), N200 for assessing spatial attention (Woodman and Luck 2003), N250 as index of familiarity of face (Tanaka et al 2006) and P300 as a novelty or attention marker (Jeon and Polich 2001; Polich and Comerchero 2003). However, unlike those mentioned components, the N100 component, the negative deflection peak around 100 ms after the onset of stimulus, can be obtained from many if not all tasks in sensory domains.…”

Section: Introductionmentioning

confidence: 99%

N100 as a generic cortical electrophysiological marker based on decomposition of TMS-evoked potentials across five anatomic locations

Choa

Summerfelt

et al. 2016

Exp Brain Res

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N100, the negative peak of electrical response occurring around 100 ms, is present in diverse functional paradigms including auditory, visual, somatic, behavioral and cognitive tasks. We hypothesized that the presence of the N100 across different paradigms may be indicative of a more general property of the cerebral cortex regardless of functional or anatomic specificity. To test this hypothesis, we combined transcranial magnetic stimulation (TMS) and electroencephalography (EEG) to measure cortical excitability by TMS across cortical regions without relying on specific sensory, cognitive or behavioral modalities. The five stimulated regions included left prefrontal, left motor, left primary auditory cortices, the vertex and posterior cerebellum with stimulations performed using supra- and subthreshold intensities. EEG responses produced by TMS stimulation at the five locations all generated N100s that peaked at the vertex. The amplitudes of the N100s elicited by these five diverse cortical origins were statistically not significantly different (all uncorrected p > 0.05). No other EEG response components were found to have this global property of N100. Our findings suggest that anatomy- and modality-specific interpretation of N100 should be carefully evaluated, and N100 by TMS may be used as a bio-marker for evaluating local versus general cortical properties across the brain.

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“…Research has stated that primary cognitive disturbances in SCZ cause an inability to sufficiently filter and process sensory information, leading to disconnection of information and disrupted binding (McGhie and Chapman, 1961; Shakow, 1963; Freedman et al, 1991; Vlcek et al, 2014). Furthermore, electrophysiological studies have suggested that aberrant neural oscillations play a role for cognitive deficits in SCZ (Andreasen, 2000; Lee et al, 2003; Lisman, 2012; Pittman-Polletta et al, 2015; Senkowski and Gallinat, 2015; Uhlhaas and Singer, 2015; Keil et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Beta/Gamma Oscillations and Event-Related Potentials Indicate Aberrant Multisensory Processing in Schizophrenia

et al. 2016

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Recent behavioral and neuroimaging studies have suggested multisensory processing deficits in patients with schizophrenia (SCZ). Thus far, the neural mechanisms underlying these deficits are not well understood. Previous studies with unisensory stimulation have shown altered neural oscillations in SCZ. As such, altered oscillations could contribute to aberrant multisensory processing in this patient group. To test this assumption, we conducted an electroencephalography (EEG) study in 15 SCZ and 15 control participants in whom we examined neural oscillations and event-related potentials (ERPs) in the sound-induced flash illusion (SIFI). In the SIFI multiple auditory stimuli that are presented alongside a single visual stimulus can induce the illusory percept of multiple visual stimuli. In SCZ and control participants we compared ERPs and neural oscillations between trials that induced an illusion and trials that did not induce an illusion. On the behavioral level, SCZ (55.7%) and control participants (55.4%) did not significantly differ in illusion rates. The analysis of ERPs revealed diminished amplitudes and altered multisensory processing in SCZ compared to controls around 135 ms after stimulus onset. Moreover, the analysis of neural oscillations revealed altered 25–35 Hz power after 100 to 150 ms over occipital scalp for SCZ compared to controls. Our findings extend previous observations of aberrant neural oscillations in unisensory perception paradigms. They suggest that altered ERPs and altered occipital beta/gamma band power reflect aberrant multisensory processing in SCZ.

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Sensory disturbances, inhibitory deficits, and the P50 wave in schizophrenia

Cited by 20 publications

References 126 publications

Positive and Negative Symptoms in Schizophrenia Relate to Distinct Oscillatory Signatures of Sensory Gating

Positive and Negative Symptoms in Schizophrenia Relate to Distinct Oscillatory Signatures of Sensory Gating

N100 as a generic cortical electrophysiological marker based on decomposition of TMS-evoked potentials across five anatomic locations

Beta/Gamma Oscillations and Event-Related Potentials Indicate Aberrant Multisensory Processing in Schizophrenia

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