Sensory and Motor Interhemispheric Integration after Section of Different Portions of the Anterior Corpus Callosum in Nonepileptic Patients

Caillé, Stéphanie; Sauerwein, Hannelore C.; Schiavetto, Alessandra; Villemure, Jean‐Guy; Lassonde, Maryse

doi:10.1227/01.neu.0000163089.31657.08

Cited by 54 publications

(48 citation statements)

References 27 publications

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“…At near-term age, the genu and splenium of the CC have not yet myelinated (29), although posterior aspects (splenium) develop earlier than anterior (genu) aspects (16,30). Lesion studies indicate that genu WM mediates motor coordination (31), and prior studies reported neonatal CC WM structure associated with future motor function (32,33), consistent with our findings.…”

Section: Corpus Callosumsupporting

confidence: 87%

Neonatal brain microstructure correlates of neurodevelopment and gait in preterm children 18–22 mo of age: an MRI and DTI study

et al. 2015

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Background: Near-term brain structure was examined in preterm infants in relation to neurodevelopment. We hypothesized that near-term macrostructural brain abnormalities identified using conventional magnetic resonance imaging (MRI), and white matter (WM) microstructure detected using diffusion tensor imaging (DTI), would correlate with lower cognitive and motor development and slower, less-stable gait at 18-22 mo of age. Methods: One hundred and two very-low-birth-weight preterm infants (≤1,500 g birth weight; ≤32 wk gestational age) were recruited prior to routine near-term brain MRI at 36.6 ± 1.8 wk postmenstrual age. Cerebellar and WM macrostructure was assessed on conventional structural MRI. DTI was obtained in 66 out of 102 and WM microstructure was assessed using fractional anisotropy and mean diffusivity (MD) in six subcortical brain regions defined by DiffeoMap neonatal atlas. Neurodevelopment was assessed with Bayley-Scales-of-InfantToddler-Development, 3rd-Edition (BSID-III); gait was assessed using an instrumented mat. results: Neonates with cerebellar abnormalities identified using MRI demonstrated lower mean BSID-III cognitive composite scores (89.0 ± 10.1 vs. 97.8 ± 12.4; P = 0.002) at 18-22 mo. Neonates with higher DTI-derived left posterior limb of internal capsule (PLIC) MD demonstrated lower cognitive and motor composite scores (r = −0.368; P = 0.004; r = −0.354; P = 0.006) at 18-22 mo; neonates with higher genu MD demonstrated slower gait velocity (r = −0.374; P = 0.007). Multivariate linear regression significantly predicted cognitive (adjusted r 2 = 0.247; P = 0.002) and motor score (adjusted r 2 = 0.131; P = 0.017). conclusion: Near-term cerebellar macrostructure and PLIC and genu microstructure were predictive of early neurodevelopment and gait.

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Section: Corpus Callosumsupporting

confidence: 87%

Neonatal brain microstructure correlates of neurodevelopment and gait in preterm children 18–22 mo of age: an MRI and DTI study

et al. 2015

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“…Lower FA and higher MD values in the genu of the CC have been reported to be correlated with slower gait velocity, and lesion studies have indicated that the genus WM mediates motor coordination (29,30). Our findings are partially consistent with the previous results.…”

Section: Developmental Bivariate Correlation Analysis R Index (Postnasupporting

confidence: 92%

Gestational age, not transient hyperthyrotropinemia impacts brain white matter diffusion tensor imaging in premature infants

et al. 2017

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Abstract. Transient hypothyroidism is common in premature infants and increases the risk of adverse neurodevelopmental outcomes. Thyroid hormone (TH) is involved in oligodendrocyte development and myelination, however, whether transient hypothyroidism is associated with oligodendrocyte dysplasia and abnormal myelination is unclear. The aim of the present study was to investigate correlations among TH levels, neurodevelopmental outcomes and white matter (WM) microstructure in premature infants. The authors designed a cohort study recruiting 81 premature infants (age, 23-35 weeks). A total of 17 were born with a gestational age (GA) <30 weeks (early preterm group) and 64 of them were born with a GA ≥30 weeks (late preterm group). For outcome measurement, thyroid stimulating hormone (TSH) levels at 0, 18, and 24 h of admission were measured. Neurodevelopmental outcomes were assessed using Bayley III test. Diffusion tensor imaging was used to explore the characterization of WM microstructure. The data demonstrated that GA, however not TSH level was associated with neurodevelopmental outcomes in the following 2 years. Fractional anisotrophy (FA) increased with TSH0 levels over anterior limb of internal capsule, while axial diffusivity decreased with TSH0 levels over splenium of corpus callosum (CC). The late preterm group had more intact WM integrity over the internal and external capsule (EC) in FA compared with the early preterm group. Infants with motor dysfunction had significantly increased mean diffusivity (MD) values at regions of interest in the genu and splenium of CC.The results of the present study demonstrated that GA, however not transient hypothyroidism influenced neurodevelopmental outcomes in the premature infants. FA increased with age in a regionally-specific manner over regions of the internal capsule and EC. MD may act as a potential predictor for motor function in premature babies.

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“…This notion was built mainly on bimanual coordination deficits observed in patients with extensive lesions of the CC or partial callosotomies (Preilowski, 1972;Jeeves et al, 1988;Andres et al, 1999;Eliassen et al, 1999Eliassen et al, , 2000Wiesendanger and Serrien, 2004;Caille et al, 2005). One step toward a refined understanding of the function of the human CC would be to identify its detailed topographical organization by novel MRI techniques.…”

Section: Introductionmentioning

confidence: 99%

Human Motor Corpus Callosum: Topography, Somatotopy, and Link between Microstructure and Function

Wahl¹,

Lauterbach-Soon²,

Hattingen³

et al. 2007

J. Neurosci.

382

330

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The corpus callosum (CC) is the principal white matter fiber bundle connecting neocortical areas of the two hemispheres. Although an object of extensive research, important details about the anatomical and functional organization of the human CC are still largely unknown. Here we focused on the callosal motor fibers (CMFs) that connect the primary motor cortices (M1) of the two hemispheres. Topography and somatotopy of CMFs were explored by using a combined functional magnetic resonance imaging/diffusion tensor imaging fiber-tracking procedure. CMF microstructure was assessed by fractional anisotropy (FA), and CMF functional connectivity between the hand areas of M1 was measured by interhemispheric inhibition using paired-pulse transcranial magnetic stimulation. CMFs mapped onto the posterior body and isthmus of the CC, with hand CMFs running significantly more anteriorly and ventrally than foot CMFs. FA of the hand CMFs but not FA of the foot CMFs correlated linearly with interhemispheric inhibition between the M1 hand areas. Findings demonstrate that CMFs connecting defined body representations of M1 map onto a circumscribed region in the CC in a somatotopically organized manner. The significant and topographically specific positive correlation between FA and interhemispheric inhibition strongly suggests that microstructure can be directly linked to functional connectivity. This provides a novel way of exploring human brain function that may allow prediction of functional connectivity from variability of microstructure in healthy individuals, and potentially, abnormality of functional connectivity in neurological or psychiatric patients.

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Sensory and Motor Interhemispheric Integration after Section of Different Portions of the Anterior Corpus Callosum in Nonepileptic Patients

Abstract: The specific disconnections deficits observed in this study may provide the surgeon with information regarding the consequences of anterior callosotomy and allow for remedial measures to be implemented if required.

Cited by 54 publications

References 27 publications

Neonatal brain microstructure correlates of neurodevelopment and gait in preterm children 18–22 mo of age: an MRI and DTI study

Neonatal brain microstructure correlates of neurodevelopment and gait in preterm children 18–22 mo of age: an MRI and DTI study

Gestational age, not transient hyperthyrotropinemia impacts brain white matter diffusion tensor imaging in premature infants

Human Motor Corpus Callosum: Topography, Somatotopy, and Link between Microstructure and Function

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