Sensory and motor effects of experimental muscle pain in patients with lateral epicondylalgia and controls with delayed onset muscle soreness

Slater, Helen; Arendt‐Nielsen, Lars; Wright, Anthony; Graven‐Nielsen, Thomas

doi:10.1016/j.pain.2004.12.003

Cited by 118 publications

(118 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Previous studies demonstrated that females have less-efficient pain habituation, greater susceptibility for developing temporal summation of mechanically evoked pain, 48 and less-efficient diffuse noxious inhibitory controls than males. 13,51,54 Therefore, we do not know if our results would be similar in males. Studies with greater sample sizes are needed to permit a more generalized interpretation of these results.…”

Section: Discussionmentioning

confidence: 75%

Specific Mechanical Pain Hypersensitivity Over Peripheral Nerve Trunks in Women With Either Unilateral Epicondylalgia or Carpal Tunnel Syndrome

Fernández‐de‐las‐Peñas

Ortega‐Santiago²,

Ambite-Quesada³

et al. 2010

J Orthop Sports Phys Ther

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 75%

Specific Mechanical Pain Hypersensitivity Over Peripheral Nerve Trunks in Women With Either Unilateral Epicondylalgia or Carpal Tunnel Syndrome

Fernández‐de‐las‐Peñas

Ortega‐Santiago²,

Ambite-Quesada³

et al. 2010

J Orthop Sports Phys Ther

View full text Add to dashboard Cite

“…no prior injection of NGF) into ECRB (Slater et al 2005) did not affect PPT at the injection site, which suggests that injection of hypertonic saline into ECRB does not affect PPT at the elbow, whether pre-sensitized with NGF or not.…”

Section: Effects Of Superimposed Injection Of Hypertonic Salinementioning

confidence: 91%

“…First, NGF injection induced pain that was evoked during movement for approximately one week after a single injection (Andersen et al 2008; Study 4) and two weeks after multiple injections (Hayashi et al 2013). In contrast, pain from hypertonic saline injection lasted for up to 10 minutes and DOMS-related pain was sustained for 2-3 days after exercise (Slater et al 2005). Second, pain that is induced by injection of NGF was evoked by contraction and stretch of ECRB.…”

Section: Ngf As a Model Of Sustained Elbow Painmentioning

confidence: 99%

Movement variability and pain: Searching for a solution

Bergin¹

View full text Add to dashboard Cite

Human movement is inherently variable. In the performance of complex, multi-joint tasks, it is possible to consistently achieve an accurate outcome (i.e. low variability of the goal: VARgoal), with many different combinations of joint movements and patterns of muscle activation (i.e. variability in the elements of the movement: VARelements). It has been proposed that when the nervous system is challenged by acute experimental pain, VARelements might increase to search for a new, less painful movement strategy and then decrease if a less painful solution is found. The changes to VARelements found in situations of chronic musculoskeletal pain are more diverse. In chronic pain VARelements might be reduced, increased, not changed, or a complex interaction of these possible adaptations. All previous studies that investigated VARelements during pain evaluated multi-joint tasks (e.g. walking, pointing) that involve multiple elements. It was unclear whether VARelements would be altered in a similar manner for simple tasks with fewer elements and thus limited potential for VARelements to change.For the series of studies included in this thesis, a simple movement task was developed that involved radial-ulnar deviation of the wrist between two target angle regions. Kinematic data were collected with 3-dimensional recording systems and VARelements were considered in wrist flexionextension and forearm pronation-supination. The effect of pain on VARelements during performance of the radial-ulnar deviation task was evaluated in Studies 1-3, under various pain conditions. Study 1 investigated the influence of acute experimental pain, induced with injection of hypertonic saline, on VARelements during performance of the repetitive radial-ulnar deviation task. This study showed that, unlike that observed in more complex multi-joint systems, VARelements was reduced during acute pain in the simple task with limited elements that could change. The most likely explanation was that the motor system constrained movement in an attempt to reduce pain or exert greater control over joint motion.On the foundation of differences in the changes to VARelements for complex and simple tasks during acute pain, Study 2 investigated whether VARelements would initially increase during acute pain to gain exposure to different movement options in a search for a less painful solution. An experimental paradigm was developed where the simple task provoked moderate pain for most movements, but a less painful or non-painful solution was available that was likely to be experienced as a result of VARelements with repetition of the task. We found participants searched for, and found, a less painful movement strategy, but VARelements was not used as part of this search. Participants did not select III the strategy provided as the least painful solution by the experimental paradigm, but found a less painful strategy with gradual changes to wrist/forearm position over multiple repetitions to explore alternative movement options. The changes to VAReleme...

show abstract

“…Esta teoría está basada en la suposición de que la abertura de estas conexiones se produce por la aferentación nociceptiva desde los músculos esqueléticos y de que el dolor referido a los miotomas fuera de la lesión ocurre por la propagación de la sensibilización central a los segmentos medulares adyacentes. Sin embargo, los estudios del DMR inducido experimentalmente por Laursen y colaboradores (15)(16)(17)(18)(19) han mostrado que la producción del dolor muscular referido es dependiente del dolor muscular local y muestra una correlación con este.…”

Section: Introductionunclassified

“…Otros estímulos llegan a la médula espinal de los puntos gatillo distales y áreas disfuncionales adicionales (E y F). Los hallazgos de que los PGM causan el DR ponen en seria duda la validez interna del concepto (19). En casos crónicos el DMR se explica por el ciclo de retroalimentación mantenido por los centros cerebrales superiores que reciben impulsos originados en los PGM.…”

Section: Introductionunclassified

El dolor muscular referido es primariamente de origen periférico: la teoría de "barrera-presa"

Farasyn¹,

Cuesta‐Vargas

2013

Rev. Soc. Esp. Dolor

View full text Add to dashboard Cite

Recibido: 15-05-12. Aceptado: 21-08-12.Farasyn A, Cuesta-Vargas A. El dolor muscular referido es primariamente de origen periférico: la teoría de "barrera-presa". Rev Soc Esp Dolor 2013; 20(6): [301][302][303][304][305][306][307]. ABSTRACTThe mechanisms leading to the frequent occurrence of referred muscle pain (RP) are largely unknown. It is currently postulated that a chain reaction is activated implicating triggering of an ever-increasing number of afferent neurons and facilitation of the synaptic connection at the level of the spinal cord, causing more distally a distributed RP via convergent efferent pathways. The human interpretation of this phenomenon can be misleading when the tested person positions, after a few seconds, his RP distally from the site of pressure to the distally located RP area. As a result of what we have found in our experimentally induced RP probes, we hypothesize that deep pressure on a myo brosis will, in the rst place, within a few seconds, increase the nociceptive excitability of the afferent sensitive nerves from the RP area to the local spot of pressure on the muscle, which in return will, in the second place, excite the whole dependent RP area. The mechanism for referred muscle pain proposed in this article is linked to the ''prelocal hyper-excitability theory'' or ''barrier-dam theory''. The afferent sensitive peripheral nerves might be entrapped in local muscle hardenings (barrier-dam) with the consequence of the hyper-excitation of pre-local nerves between the distally referred pain area and the local muscular zone of tenderness. The primary pathogenesis of referred muscle pain is likely to be a peripheral sensitization with additionally a central modulation and not vice versa. Clinical and fundamental studies with experimentally induced RP are nevertheless needed to examine the hypothesis. RESUMENLos mecanismos que llevan a una alta incidencia del dolor muscular referido (DMR) son en gran medida desconocidos. En la actualidad, se postula que se produce la activación de una reacción en cadena que implica el desencadenamiento de la excitación de neuronas aferentes y la facilitación de las conexiones sinápticas al nivel de la médula espinal, lo cual produce el DMR distribuido más distalmente a través de las vías convergentes eferentes. Como resultado de los hallazgos de nuestros estudios del DMR inducido experimentalmente, se puede plantear la hipótesis de que la presión profunda sobre la zona de mio brosis incrementará primariamente la excitabilidad nociceptiva de los nervios aferentes sensitivos desde el área de DMR hasta el sitio de la presión local en el músculo en pocos segundos, lo cual a su vez excitará secundariamente el área total dependiente de DMR. El mecanismo propuesto en este artículo para el dolor muscular referido está ligado a la teoría de la "hiperexcitabilidad pre-local" o la "teoría de barrera-presa". Los nervios aferentes sensitivos periféricos pueden ser atrapados en los endurecimientos musculares locales (barrera-represa), con la consecuencia de la hipe...

show abstract

Sensory and motor effects of experimental muscle pain in patients with lateral epicondylalgia and controls with delayed onset muscle soreness

Cited by 118 publications

References 56 publications

Specific Mechanical Pain Hypersensitivity Over Peripheral Nerve Trunks in Women With Either Unilateral Epicondylalgia or Carpal Tunnel Syndrome

Specific Mechanical Pain Hypersensitivity Over Peripheral Nerve Trunks in Women With Either Unilateral Epicondylalgia or Carpal Tunnel Syndrome

Movement variability and pain: Searching for a solution

El dolor muscular referido es primariamente de origen periférico: la teoría de "barrera-presa"

Contact Info

Product

Resources

About