Sensory and motor aspects of addiction

Yalachkov, Yavor; Kaiser, Jochen; Naumer, Marcus J.

doi:10.1016/j.bbr.2009.09.015

Cited by 93 publications

(86 citation statements)

References 92 publications

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“…Speculatively, the idea that the motor system plays a crucial role not only for controlling the elementary physical features of movement (e.g., force, direction, and amplitude), but also for higher functions (i.e., to understand and to shape behavior; see the introduction), radically changes the way in which we conceive others' behavior and our own (Gallese, 2007;Sinigaglia, 2013;Sinigaglia & Rizzolatti, 2011). Moreover-even if clinical studies testing (i.e., proving or falsifying) such a hypothesis are necessary-it seems plausible that the plasticity of the cortical motor system may be considered in order to tackle the automatized and compulsive drug-seeking/drug-taking behaviors in substance abuse disorders (Smolka et al, 2006;Wagner et al, 2011;Yalachkov et al, 2009; for a review, see Yalachkov et al, 2010). The transition from use to abuse, and then to addiction, is a critical concept for rehabilitation.…”

Section: Discussionmentioning

confidence: 99%

“…From a neurobiological perspective, such a transition would reflect a dynamic shift in the neural loci of control over behavior (i.e., from the ventral to dorsal striatum, in combination with a progressive decrease in prefrontal cortical control; Everitt & Robbins, 2013;Garavan et al, 2000;Volkow et al, 2006;Vollstädt-Klein et al, 2011). Although the role of motor processes in the neurobiology of addiction has been widely underestimated or even neglected in past decades (Yalachkov, Kaiser, & Naumer, 2010), more recently it has been hypothesized that motor mechanisms play Fig. 3 Drug use, drug abuse, and drug dependence: three consecutive but independent phases with increasing severity.…”

Section: Motor Cognition In Asd: Motor Anomalies Impacting On Social mentioning

confidence: 99%

“…By using an orientation affordance paradigm (i.e., a stimulus-response compatibility paradigm; see Riggio et al, 2008;Tucker & Ellis, 1998;Vainio, Ellis, & Tucker, 2007), Yalachkov et al (2009) found that smokers (but not nonsmokers) showed an automatized responsiveness to smoking paraphernalia similar to that for everyday objects (Yalachkov et al, 2009). Furthermore, from a neural point of view, smokers had higher fMRI activations than nonsmokers not only in regions classically known to be involved in addiction (i.e., left ventral and dorsal striatum, dorsolateral prefrontal cortex, insula, uncus, medial frontal gyrus, right posterior subcallosal gyrus, and bilateral parahippocampal gyrus), but also in a second, Bmotor^network involving bilateral premotor cortex, left superior parietal lobule, and right lateral cerebellum (Yalachkov et al, 2009; for a review, see Yalachkov, Kaiser, & Naumer, 2010). These findings seem to suggest that smoking cues in smokers can automatically activate the neural regions encoding the motor representation of Btool use^skills and action meaning (i.e., areas related to motor cognition mechanisms).…”

Section: Motor Cognition In Asd: Motor Anomalies Impacting On Social mentioning

confidence: 99%

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The motor way: Clinical implications of understanding and shaping actions with the motor system in autism and drug addiction

Casartelli

Chiamulera

2015

Cogn Affect Behav Neurosci

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To understand others' minds is crucial for survival; however, it is quite puzzling how access to others' minds can be-to some extent-direct and not necessarily mediated by conceptual reasoning. Recent advances in neuroscience have led to hypothesize a role for motor circuits not only in controlling the elementary physical features of movement (e.g., force, direction, and amplitude), but also in understanding and shaping human behavior. The concept of Bmotor cognition^refers to these aspects, and neurophysiological, neuroimaging, and behavioral studies in human and nonhuman primates support this view. From a clinical perspective, motor cognition represents a challenge in several domains. A thorough investigation of the neural mechanisms mediating motor action/intention understanding and automatized/compulsive behaviors seems to be a promising way to tackle a range of neurodevelopmental and drug-related disorders. On the one hand, anomalies in motor cognition may have cascade effects on social functioning in individuals with autism spectrum disorder (ASD); on the other, motor cognition may help explain the pathophysiology of drug-seeking and drug-taking behaviors in the most severe phase of drug addiction (i.e., see drug dependence, motor low-order cue reactivity). This may represent a promising approach that could improve the efficacy of rehabilitative interventions. The only way to shed light on multifactorial disorders such as ASD and drug addiction is through the investigation of their multiple factors. This motor way can promote new theoretical and experimental perspectives that would help bridge the gap between the basic neuroscience approach and clinical practice.

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Section: Discussionmentioning

confidence: 99%

Section: Motor Cognition In Asd: Motor Anomalies Impacting On Social mentioning

confidence: 99%

Section: Motor Cognition In Asd: Motor Anomalies Impacting On Social mentioning

confidence: 99%

See 1 more Smart Citation

The motor way: Clinical implications of understanding and shaping actions with the motor system in autism and drug addiction

Casartelli

Chiamulera

2015

Cogn Affect Behav Neurosci

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“…Drug addiction, which is also manifested by a powerful craving for the drug, occurs mainly after a prolonged history of drug use and in 20% -40% of users, depending on the drug (Anthony et al 1994;Nutt et al 2007). Drug addiction is a complex brain disorder (Leshner 1997) associated with dysfunctions in the motivational (Kalivas and Volkow 2005), emotional (Goldstein et al 2009), learning Yalachkov et al 2010), and behavioral control systems (Baler and Volkow 2006;Volkow et al 2010;Ersche et al 2011Ersche et al , 2012.…”

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confidence: 99%

Responses to Novelty and Vulnerability to Cocaine Addiction: Contribution of a Multi-Symptomatic Animal Model

Belin

Deroche-Gamonet

2012

Cold Spring Harbor Perspectives in Medicine

121

113

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Epidemiological studies have revealed striking associations between several distinct behavioral/personality traits and drug addiction, with a large emphasis on the sensation-seeking trait and the associated impulsive dimension of personality. However, in human studies, it is difficult to identify whether personality/behavioral traits actually contribute to increased vulnerability to drug addiction or reflect psychobiological adaptations to chronic drug exposure. Here we show how animal models, including the first multi-symptomatic model of addiction in the rat, have contributed to a better understanding of the relationships between different subdimensions of the sensation-seeking trait and different stages of the development of cocaine addiction, from vulnerability to initiation of cocaine self-administration to the transition to compulsive drug intake. We argue that sensation seeking predicts vulnerability to use cocaine, whereas novelty seeking, akin to high impulsivity, predicts instead vulnerability to shift from controlled to compulsive cocaine use, that is, addiction.

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“…Also, lobule VIII is a component of the sensorimotor network (Schmahmann, 1991;, and it has been included as part of "the limbic cerebellum" . Finally, it seems to be crucial in automatizing behavioural repertories towards drug-related cues (see Yalachkov et al, 2010 for a review).…”

Section: Introductionmentioning

confidence: 99%

Involvement of the cerebellum in cocaine-induced memory

Gas¹

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PREFACEBecause of its role in drug-seeking, consumption and addictive behavior, there is a growing interest in identifying the neural circuits and molecular mechanisms underlying the formation, maintenance and retrieval of drug-induced memories. However, very few studies have focused on brain areas beyond the corticostriatal-limbic circuitry. Despite the growing evidence confirming the involvement of the cerebellum in drug-induced alterations, this structure has been traditionally disregarded in the addiction field Miquel et al, 2016).The general aim of the present research is to address wether the cerebellum is part of the neuronal systems that sustains the plasticity mechanisms underlying drug-induced conditioned memories. We have focused our research in an attempt to clarify if the cerebellum is involved in the acquisition and storage of drug memories. Although previous scattered reports described the involvement of the cerebellum in drug-related memories, this is the first attempt to address a detailed functional analysis about the issue.The present doctoral thesis contains three different chapters. The first two include two investigations that have been already published (Carbo-gas et al., 2014ab), and the third is one currently under revision. In the first chapter, Involving the cerebellum in cocaineinduced memory: pattern of cFos expression in mice trained to acquire conditioned preference for cocaine, we explored the pattern of neuronal activation as revealed by cFos immunoreactivity of mice trained to develop conditioned preference for an olfactory stimulus paired with cocaine. In the second one, entitled Cerebellar hallmarks of conditioned preference for cocaine, we used the same behavioral task of the first study in order to further extend the description of cFos expression patterns in cerebellar circuitry, including now the major inputs and one of the output nuclei of the cerebellum. 9In the last chapter, Cerebellar perineuronal nets in cocaine-induced Pavlovian memory:site does matter, we accomplished a broad analysis of perineuronal nets (PNNs) expression of cerebellar vermis. First, we analysed an outbred mouse strain trained to acquire preference for olfactory stimuli associated with cocaine. Second, α6Cre-Cacna1a mice were used to test if a reduction in the glutamate release of parallel fibres to Purkinje dendrites would alter the acquisition of cocainepreference conditioning and the expression of PNNs in the cerebellum.After the presentation of the chapters, there is a section where summarised findings, strengths and pitfalls as well as future directions are provided. References can be also found at the end of the present document.Finally, we conclude this thesis with an appendix. This document is formed by research not finished yet, but that may be of great relevance to understand the role of the cerebellum in addictive disorders. In that appendix, we explored the effect of a focal lesion in the dorsal cerebellar cortex (Lobule VIII) on the acquisition of food selfadministration. This researc...

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Sensory and motor aspects of addiction

Cited by 93 publications

References 92 publications

The motor way: Clinical implications of understanding and shaping actions with the motor system in autism and drug addiction

The motor way: Clinical implications of understanding and shaping actions with the motor system in autism and drug addiction

Responses to Novelty and Vulnerability to Cocaine Addiction: Contribution of a Multi-Symptomatic Animal Model

Involvement of the cerebellum in cocaine-induced memory

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